Phosphorylation of vitronectin on Ser362 by protein kinase C attenuates its cleavage by plasmin

European Journal of Biochemistry

Volumn 243, Issue 1-2, 1997, Pages 493-501

  Gechtman, Zeev ^a   Shaltiel, Shmuel ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Phosphorylation and proteolysis; Plasmin; Plasminogen activator inhibitor 1; Protein kinase C; Vitronectin

Indexed keywords

PLASMIN; PROTEIN KINASE C; VITRONECTIN;

ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEEDBACK SYSTEM; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

EID: 0031038474     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.0493a.x     Document Type: Article

References (56)

1. Preissner, K. T. (1991) Structure and biological role of vitronectin, Annu Rev. Cell Biol. 7, 275-310.
2. Tomasini, B. R. & Mosher, D. F. (1991) Vitronectin, Prog. Hemostasis Thromb. 10, 269-305.
3. Felding, H. B. & Cheresh, D. A. (1993) Vitronectin and its receptors, Curr. Opin. Cell. Biol. 5, 864-868.
4. Declerck, P. J., DeMol, M., Alessi, M. C., Baudner, S., Paques, E. P., Preissner, K. T., Muller-Berghaus, G. & Collen, D. (1988) Purification and characterization of a plasminogen activator in-hibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin), J. Biol. Chem. 263, 15454-15461.
5. Lindahl, T. L., Sigurdardottir, O. & Wiman, B. (1989) Stability of plasminogen activator inhibitor 1 (PAI-1), Thromb. Haemostasis 62, 748-751.
6. Lindahl, T. & Wiman, B. (1989) Purification of high and low molecular mass plasminogen activator inhibitor 1 from fibrosarcoma cell-line HT 1080 conditioned medium, Biochim. Biophys. Acta 994, 253-257.
7. Preissner, K. T., Holzhuter, S., Justus, C. & Muller-Berghaus, G. (1989) Identification of and partial characterization of platelet vitronectin: evidence for complex formation with platelet-derived plasminogen activator inhibitor-1, Blood 74, 1989-1996.
8. Salonen, E. M. Vaheri, A., Pollanen, J., Stephens, R., Andreasen, P., Mayer, M., Dano, K., Gailit, J. & Ruoslahti, E. (1989) Interaction of plasminogen activator inhibitor (PAI-1) with vitronectin, J. Biol. Chem. 264, 6339-6343.
9. Wiman, B., Almquist, A., Sigurdardottir O. & Lindahl, T. (1988) Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma, FEBS Lett. 242, 125-128.
10. Seiffert, D., Mimuro, J., Schleef, R. R. & Loskutoff, D. J. (1990) Interactions between type 1 plasminogen activator inhibitor, extracellular matrix and vitronectin, Cell Differ. Dev. 32, 287-292.
11. Sigurdardottir, O. & Wiman, B. (1990) Complex formation between plasminogen activator inhibitor 1 and vitronectin in purified systems and in plasma, Biochim. Biophys. Acta 1035, 56-61.
12. Owensby, D. A., Morton, P. A., Wun, T. C. & Schwartz, A. L. (1991) Binding of plasminogen activator inhibitor type-1 to extracellular matrix of Hep G2 cells. Evidence that the binding protein is vitronectin, J. Biol. Chem. 266, 4334-4340.
13. Korc-Grodzicki, B., Tauber-Finkelstein, M. & Shaltiel, S. (1988) Platelet stimulation releases a cAMP-dependent protein kinase that specifically phosphorylates a plasma protein, Proc. Natl Acad. Sci. USA 85, 7541-7545.
14. Korc-Grodzicki, B., Tauber-Finkelstein, M., Chain, D. & Shaltiel, S. (1988) Vitronectin is phosphorylated by a cAMP-dependent protein kinase released by activation of human platelets with thrombin, Biochem. Biophys. Res. Commun. 157, 1131-1138.
15. Chain, D., Korc-Grodzicki, B., Kreizman, T. & Shaltiel, S. (1991) Endogenous cleavage of the Arg-379-Ala-380 bond in vitronectin results in a distinct conformational change which 'buries' Ser-378, its site of phosphorylation by protein kinase A. Biochem. J. 274, 387-394.
16. Mehringer, J. H., Weigel, C. J. & Tollefsen, D. M. (1991) Cyclic AMP-dependent protein kinase phosphorylates serine378 in vitronectin, Biochem. Biophys. Res. Commun. 179, 655-660.
17. Suzuki, S., Pierschbacher, M. D., Hayman, E. G., Nguyen, K., Ohgren, Y. & Ruoslahti, E. (1984) Domain structure of vitronectin. Alignment of active sites, J. Biol. Chem. 259, 15 307-15 314.
18. Kost, C., Stuber, W., Ehrlich, H. J., Pannekoek, H. & Preissner, K. T. (1992) Mapping of binding sites for heparin, plasminogen activator inhibitor-1, and plasminogen to vitronectin's heparin-binding region reveals a novel vitronectin-dependent feedback mechanism for the control of plasmin formation. J. Biol. Chem. 267, 12 098-12 105.
19. Gechtman, Z., Sharma, R., Kreizman, T., Fridkin, M. & Shaltiel, S. (1993) Synthetic peptides derived from the sequence around the plasmin cleavage site in vitronectin. Use in mapping the PAI-1 binding site, FEBS Lett. 315, 293-297.
20. Shaltiel, S., Schwartz, I., Korc-Grodzicki, B. & Kreizman, T. (1993) Evidence for an extra-cellular function for protein kinase A, Mol. Cell. Biochem. 127, 283-287.
21. Chain, D., Korc-Grodzicki, B., Kreizman, T. & Shaltiel, S. (1990) The phosphorylation of the two-chain form of vitronectin by protein kinase A is heparin dependent, FEBS Lett. 269, 221-225.
22. Shaltiel, S., Schwartz, I., Gechtman, Z. & Kreizman, T. (1993) Covalent modulation of vitronectin structure for the control of plasminogen activation by PAI-1, in Biology of vitronectins and their receptors (Preissner, K. T., Rosenblatt, S., Kost, C., Wegerhoff, J. & Mosher, D. F., eds) pp. 311-320, Elsevier Science, Amsterdam.
23. Korc-Grodzicki, B. (1990) The release of PKA from stimulated platelets and the identification of its target substrate in plasma, PhD Thesis, Weizmann Institute of Science, Rehovot, Israel.
24. Sane, D. C., Moser, T. L. & Greenberg, C. S. (1991) Vitronectin in the substratum of endothelial cells is cross-linked and phosphorylated, Biochem. Biophys. Res. Commun. 174, 465-469.
25. Skubitz, K. M. & Ehresmann, D. D. (1992) The angiogenesis inhibitor beta-cyclodextrin tetradecasulfate inhibits ecto-protein kinase activity, Cell Mol. Biol. 38, 543-560.
26. Chain, D., Kreizman, T., Shapira, H. & Shaltiel, S. (1991) Plasmin cleavage of vitronectin. Identification of the site and consequent attenuation in binding plasminogen activator inhibitor-1, FEBS Lett. 285, 251-256.
27. Dahlback, B. & Podack, E. R. (1985) Characterization of human S protein, an inhibitor of the membrane attack complex of complement. Demonstration of a free reactive thiol group, Biochemistry 24, 2368-2374.
28. Beavo, J. A., Bechtel, P. G. & Krebs, E. G. (1974) Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle. Methods Enzymol. 38, 299-308.
29. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680-685.
30. Boyle, W. J., van-der Geer, P. & Hunter, T. (1991) Phosphopeptide mapping and phosphoaminoacid analysis by two-dimensional separation on thin-layer cellulose plates, Methods Enzymol. 201, 110-148.
31. Feige, J. J. & Baird, A. (1989) Basic fibroblast growth factor is a substrate for protein phosphorylation and is phosphorylated by capillary endothelial cells in culture, Proc. Natl Acad. Sci. USA 86, 3174-3178.
32. Forsberg, P. O., Martin, S. C., Nilsson, B., Ekman, P., Nilsson, U. R. & Engstrom, L. (1990) In vitro phosphorylation of human complement factor C3 by protein kinase A and protein kinase C. Effects on the classical and alternative pathways, J. Biol. Chem. 265, 2941-2946.
33. Kishimoto, A., Nishiyama, K., Nakanishi, H., Uralsuji, Y., Nomura, H., Takeyama, Y. & Nishizuka, Y. (1985) Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3′:5′-monophosphate-dependent protein kinase. J. Biol. Chem. 260, 12 492-12 499.
34. Woodgett, J. R., Gould, K. L. & Hunter, T. (1986) Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements, Eur. J. Biochem. 161, 177-184.
35. 2+-dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein, J. Biol. Chem. 260, 11 503-11 507.
36. 2+/phospholipid-dependent protein kinase (protein kinase C) and cAMP-dependent protein kinase as evidenced by synthetic peptide substrates, FEBS Lett. 184, 72-77.
37. 2+ phospholipid-dependent and independent phosphorylation of synthetic p eptide substrates by protein kinase C. Eur. J. Biochem. 163, 481-487.
38. Benore-Parsons, M., Seidah, N. G. & Wennogle, L. P. (1989) Substrate phosphorylation can inhibit proteolysis by trypsin-like enzymes, Arch. Biochem. Biophys. 272, 274-280.
39. Wang, Y. H., Fiol, C. J., DePaoli, R. A., Bell, A. W., Hermodson, M. A. & Roach, P. J. (1988) Identification of phosphorylation sites in peptides using a gas-phase sequencer. Anal. Biochem. 174, 537-547.
40. Feige, J. J., Bradley, J. D., Fryburg, K., Farris, J., Cousens, L. C., Barr, P. J. & Baird, A. (1989) Differential effects of heparin, fibronectin, and luminin on the phosphorylation of basic fibroblast growth factor by protein kinase C and the catalytic subunit of protein kinase A. J. Cell. Biol. 109, 3105-3114.
41. Herbert, J. M. & Maffrand, J. P. (1991) Effect of pentosan polysulphate, standard heparin and related compounds on protein kinase C activity, Biochim. Biophys. Acta 1091, 432-441.
42. Kost, C., Benner, K., Stockmann, A., Linder, D. & Preissner, K. (1996) Limited plasmin proteolysis of vitronectin. Characterization of the adhesion protein as a morphoregulatory and angiostatin binding factor, Eur. J. Biochem. 236, 682-688.
43. Suzuki, S., Oldberg, A., Hayman, E. G., Pierschbacher, M. D. & Ruoslahti, E. (1985) Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin, EMBO J. 4, 2519-2524.
44. Korc-Grodzicki, B., Chain, D., Kreizman, T. & Shaltiel, S. (1990) An enzymatic assay for vitronectin based on its selective phosphorylation by protein kinase A, Anal. Biochem. 188, 288-294.
45. Kalafatis, M., Rand, M. D., Jenny, R. J., Ehrlich, Y. H. & Mann, K. G. (1993) Phosphorylation of factor Va and factor VIIIa by activated platelets, Blood 81, 704-719.
46. Rand, M. D., Kalafatis, M. & Mann, K. G. (1994) Platelet coagulation factor Va: the major secretory platelet phosphoprotein, Blood 83, 2180-2190.
47. Heldin, P. & Humble, E. (1987) Phosphorylation of human fibrinogen in vitro with protein kinase C: characterization of the phosphorylated sites. Arch. Biochem. Biophys. 252, 49-59.
48. Abe, K. (1993) A study on the participation of protein kinase C in the blood coagulation, Hokkaido J. Med. Sci. 68, 368-376.
49. Hogan, M. V., Pawlowska, Z., Yang, H. A., Kornecki, E. & Ehrlich, Y. H. (1995) Surface phosphorylation by ecto-protein kinase C in brain neurons: a target for Alzheimer's beta-amyloid peptides, J. Neurochem. 65, 2022-2030.
50. Forsberg, P. O. & Martin, S. C. (1990) Plasmin digestion of human fibrinogen previously phosphorylated by protein kinase C or dephosphorylated by alkaline phosphatase in vitro, Thromb. Res. 58, 119-127.
51. Martin, S. C., Forsberg, P. O. & Eriksson, S. D. (1991) The effects of in vitro phosphorylation and dephosphorylation on the thrombin-induced gelation and plasmin degradation of fibrinogen, Thromb. Res. 61, 243-252.
52. Ekdahl, K. N. & Nilsson, B. (1995) Phosphorylation of complement component C3 and C3 fragments by a human platelet protein kinase. Inhibition of factor I-mediated cleavage of C3b. J. Immunol. 154, 6502-6510.
53. Jenne, D. & Stanley, K. K. (1985) Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion, EMBO J. 4, 3153-3157.
54. Seiffert, D. & Loskutoff, D. J. (1991) Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin, J. Biol. Chem. 266, 2824-2830.
55. Seiffert, D., Ciambrone, G., Wagner, N. V. Binder, B. R. & Loskutoff, D. J. (1994) The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor, J. Biol. Chem. 266, 2659-2666.
56. Deng, G., Royle, G., Wang, S., Crain, K. & Loskutoff, D. J. (1996). Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin, J. Biol. Chem. 27, 12 716-12 723.