Low-Dose Recombinant Human Growth Hormone as Adjuvant Therapy to Lifestyle Modifications in the Management of Obesity

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 2, 2004, Pages 695-701

  Albert, Stewart G ^a   Mooradian, Arshag D ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; RECOMBINANT GROWTH HORMONE;

ADJUVANT THERAPY; ADULT; ARTICLE; BODY FAT; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE CALCULATION; DOUBLE BLIND PROCEDURE; DRUG SELF ADMINISTRATION; DRUG WITHDRAWAL; EDEMA; ENERGY EXPENDITURE; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HORMONAL THERAPY; HUMAN; INSULIN SENSITIVITY; LIFESTYLE; LOW DRUG DOSE; MALE; MORBID OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; WEIGHT REDUCTION;

ADIPOSE TISSUE; ADULT; BODY COMPOSITION; BODY WEIGHT; CHEMOTHERAPY, ADJUVANT; DOUBLE-BLIND METHOD; FEMALE; GROWTH HORMONE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LIFE STYLE; LIPIDS; MALE; OBESITY; ORGAN SIZE;

EID: 1442352241     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-031264     Document Type: Article

References (48)

1. Scacchi M, Pincelli AI, Cavagnini F 1999 Growth hormone in obesity. Int J Obes Relat Metab Disord 23:262-271
2. Kanaley JA, Weatherup-Dentes MM, Jaynes EB, Hartman ML 1999 Obesity attenuates the growth hormone response to exercise. J Clin Endocrinol Metab 84:3156-3161
3. Rasmussen MH, Juul A, Kjems LL, Skakkebaek NE, Hilsted J 1995 lack of stimulation of 24-hour growth hormone release by hypocaloric diet in obesity. J Clin Endocrinol Metab 80:796-801
4. Maccario M, Ramunni J, Oleandri SE, Procopio M, Grottoli S, Rossetto R, Savio P, Almaretti G, Camannni F, Ghigo E 1999 Relationships between IGF-I an age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients. Int J Obes 23:612-618
5. Grottoli S, Procopio M, Maccaario M, Zini M, Oleandri SE, Tassone F, Valcavi R, Ghigo E 1997 In obesity, glucose load loses its early inhibitory, but maintains its late stimulatory, effects on somatotrope secretion. J Clin Endocrinol Metab 82:2261-2265
6. Rasmussen MH, Hvidberg A, Juul A, Main KM, Gotfredsen A, Skakkebae NE, Hilsted J 1995 Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects. J Clin Endocrinol Metab 80:1407-1415
7. Tanaka K, Inbue S, Numata K, Okazaki H, Nakamura S, Takamura Y 1990 Very-low calorie diet-induced weight reduction reverses impaired growth hormone secretion response to growth hormone-releasing hormone, arginine, and L-dopa in obesity. Metabolism 39:892-896
8. Snyder DK, Underwood LE, Clemmons DR 1995 Persistent lipolytic effect of exogenous growth hormone during caloric restrictions. Am J Med 98:129-134
9. Drent ML, Wever LDV, Ader HJ, van der Veen EA 1995 Growth hormone administration in addition to a very low calorie diet and an exercise program in obese subjects. Eur J Endocrinol 132:565-572
10. Thompson JL, Butterfield GE, Gylfadottir UK, Yesavage J, Marcus R, Hintz RL, Pearman A, Hoffman AR 1998 Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women. J Clin Endocrinol Metab 83:1477-1484
11. Clemmons DR, Snyder DK, Williams R, Underwood LE 1987 Growth hormone administration conserves lean body mass during dietary restriction in obese subjects. J Clin Endocrinol Metab 64:878-883
12. Carroll PV, Christ ER, Bengtsson BA, Carlsson L, Christiansen JS, CLemmons D, Hintz R, HO K, Laron Z, Sizonenko P, Sonksen PH, Tanaka T, Thorner M 1998 Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. J Clin Endocrinol Metab 83:382-395
13. Newman CB, Kleinberg DL 1998 Adult growth hormone deficiency. Endocrinologist 8:178-186
14. Drake WM, Coyte D, Camacho-Hubner C, Jivanji NM, Kaltas G, Wood DF, Trainer PJ, Grossman AB, Besser GM, Monson JP 1998 Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults. J Clin Endocrinol Metab 83:3913-3919
15. Murray RD, Skillicorn CJ, Howell SJ, Lissett CA, Rahim A, Shalet SM 1999 Dose titration and patient selection increases the efficacy of GH replacement in severely GH deficient adults. Clin Endocrinol (Oxf) 50:749-757
16. Monson JP, Abs R, Bengtsson BA, Bennmarker H, Feldt-Rasmussen U, Hernberg-Stahl E, Thoren M, Westberg B, Wilton P, Wuster C 2000 Growth hormone deficiency and replacement in elderly hypopituitary adults. KIMS Study Group and the KIMS International Board. Pharmacia and Upjohn International Metabolic Database. Clin Endocrinol (Oxf) 53:281-289
17. Monson JP 2001 Biochemical markers of individual response to growth hormone replacement in adults. Horm Res 55(Suppl 2):49-54
18. de Boer H, Blok GJ, Popp-Snijders C, Stuurman L, Baxter RC, van der Veen E 1996 Monitoring of growth hormone replacement therapy in adults, based on measurement of serum markers. J Clin Endocrinol Metab 81:1371-1377
19. Burman P, Johansson AG, Siegbahn A, Vessby B, Kaarlsson FA 1997 Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women. J Clin Endocrinol Metab 82:550-555
20. Nam SY, Kim KR, Cha BS, Song YD, Lim SK, Lee HC, Huh KB 2001 Low-dose growth hormone treatment combined with diet restriction decreases insulin resistance by reducing visceral fat and increasing muscle mass in obese type 2 diabetic patients. Int J Obes Relat Metab Disord 25:1101-1107
21. Kim KR, Nam SY, Song YD, Lim SK, Lee HC, Huh KB 1999 Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dysfunction in adults. Horm Res 51:78-84
22. Tagliaferri M, Scacchi M, Pincelli AI, Berselli ME, Silvestri P, Montesano A, Ortolani S, Dubini A, Cavagnini F 1998 Metabolic effects of biosynthetic growth hormone treatment in severely energy-restricted obese women. Int J Obes Relat Metab Disord 22:836-841
23. Karlsson C, Stenlof K, Johannsson G, Marin P, Bjorntorp P, Bengtsson BA, Carlsson B, Carlsson LM, Sjostrom L 1998 Effects of growth hormone treatment on the leptin system and on energy expenditure in abdominally obese men. Eur J Endocrinol 138:408-414
24. Johannsson G, Marin P, Lonn L, Ottosson M, Stenlof K, Bjorntorp P, Sjostrom L, Bengtssib B-A 1997 Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab 82:7237-734
25. Sesmilo G, Biller B, Llevadot J, Hayden D, Hanson G, Rifai N, Klibanski A 2000 Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency: a randomized, controlled clinical trial. Ann Intern Med 133:111-122
26. Hadigan C, Miller C, Corcoran C, Anderson E, Basgoz N, Grinspoon S 1999 Fasting hyperinsulinemia and changes in regional body composition in human immunodeficiency virus-infected women. J Clin Endocrinol Metab 84:1932-1937
27. Radziuk J 2000 Insulin sensitivity and its measurement: structural commonalities among methods. J Clin Endocrinol Metab 85:4426-4433
28. Arterburn D 2003 Obesity. Clin Evidence 9:122-124
29. Weigle DS 2003 Pharmacological therapy of obesity: past, present, and future. J Clin Endocrinol Metab 88:2462-2469
30. Rosenbaum M, Leibel RL, Hirsch J 1997 Obestiy. N Engl J Med 337:396-407
31. Leibel RL, Rosenbaum M, Hirsch J 1995 changes in energy expenditure resulting from altered body weight. N Engl J Med 332:621-628
32. de Boer H, Blok GJ, Voerman B, Derriks P, van der Veen E 1996 Changes in subcutaneous and visceral fat mass during growth hormone replacement therapy in adult men. Int J Obes Relat Metab Disord 20:580-587
33. Johannsson G, Rosen T, Bosaeus I, Sjostrom L, Bengtsson BA 1996 Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency. J Clin Endocrinol Metab 81:2865-2873
34. Johannsson G, Grimby G, Sunnerhagen KS, Bengtsson BA 1997 Two years of growth hormone (GH) treatment increase isometric and isokinetic muscle strength in GH-deficient adults J Clin Endocrinol Metab 82:2877-2884
35. Lange KH, Andersen JL, Beyer N, Isaksson F, Larsson B, Rasmussen MH, Juul A, Bulow J, Kjaer M 2002 GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men. J Clin Endocrinol Metab 87:513-523
36. Colao A, di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G 2002 The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study. J Clin Endocrinol Metab 87:1088-1093
37. Svensson J, Fowelin J, Landin K, Bengtsson BA, Johansson JO 2002 Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults. J Clin Endocrinol Metab 87:2121-2127
38. Lonn L, Johansson G, Sjostrom L, Kvist H, Oden A, Bengtsson BA 1996 Body composition and tissue distributions in growth hormone deficient adults before and after growth hormone treatment. Obes Res 4:45-54
39. Johannson G, Albertsson-Wikland K, Bengtsson B-A 1999 Discontinuation of growth hormone (GH) treatment: metabolic effects in GH-deficient and GH-sufficient adolescent patients compared with controls subjects. J Clin Endocrinol Metab 84:4516-4524
40. Beentjes JAM, van Tol A, Sluiter WJ, Dullaart RPF 2000 Effect of growth hormone replacement therapy on plasma lecithin: cholesterol acyltransferase and lipid transfer protein activities in growth hormone-deficient adults. J Lipid Res 41:925-932
41. Twickler TB, Cramer MJM, Dallinga-Thie GM, Chapman MJ, Erkelens DW, Koppeschaar HPF 2003 Adult-onset growth hormone deficiency: relation of postprandial dyslipidemia to premature atherosclerosis. J Clin Endocrinol Metab 88:2479-2488
42. Rosenfalck AM, Maghsoudi S, Fisker S, Jorgensen JOL, Christiansen JS, Hilsted J, Volund A, Madsbad S 2000 The effect of 30 months of low-dose replacement therapy with recombinant human growth hormone (rhGH) on insulin and C-peptide kinetics, insulin secretion, insulin sensitivity, glucose effectiveness, and body composition in GH-deficient adults. J Clin Endocrinol Metab 85:4173-4181
43. Hwu C-M, Kwok CF, Lai T-Y, Shih K-C, Lee T-S, Hsaio L-C, Lee S-H, Fang VS, Ho L-T 1997 Growth hormone (GH) replacement reduces total body fat and normalizes insulin sensitivity in GH-deficient adults: a report o one-year clinical experience. J Clin Endocrinol Metab 82:3285-3292
44. Blackman MR, Sorkin JD, Munzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, Jayme J, O'Connor KG, Christma C, Tobin JD, Stewart KJ, Cottrell E, St Clair C, Pabst KM, Harman SM 2002 Growth hormone and sex steroid administration in healthy aged women and men. A randomized controlled trial. JAMA 288:2282-2292
45. Foster GD, Wyatt HR, Hill JO, McGuckin BG, Brill C, Mohammed BS, Szapary PO, Rader DJ, Edman JS, Klein S 2003 A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 348:2082-2090
46. Samaha FF, Iqbal N, Seshadri P, Chicano KL, Daily DA, McGrory J, Williams T, Williams M, Gracely EJ, Stern L 2003 A low-carbohydrate as compared with a low-fat diet in severe obesity. N Engl J Med 348:2074-2081
47. Lupu F, Terwilliger JD, Lee K, Segre GV, Efstratiadis A 2001 Roles of growth hormone and insulin-like growth factor I in mouse postnatal growth. Dev Biol 229:141-162
48. Arnhold IJ, Oliveira SB, Osorio MG, Carrilho AJ, Nicolau W, Bianco AC, Mendonca BB 2000 Lack of reduction in body fat after treatment with insulin-like growth factor-I in two children with growth hormone gene deletion. J Endocrinol Invest 23:258-262