Wolbachia endosymbionts of Onchocerca volvulus express a putative periplasmic HtrA-type serine protease

Microbes and Infection

Volumn 6, Issue 2, 2004, Pages 141-149

  Jolodar, Abbas ^a   Fischer, Peter ^a   Büttner, Dietrich W ^a   Brattig, Norbert W ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

Endobacteria; Filaria; High temperature requirement A protease; HtrA; HtrA protease; Immunolocalisation; Onchocerca volvulus; ORF; PCR; Polymerase chain reaction; Serine protease; Wol Ov HtrA; Wolbachia; Wolbachia surface protein; Wolbachia O. volvulus HtrA; WSP

Indexed keywords

ANTIGEN; ANTISERUM; BACTERIAL PROTEIN; CHAPERONE; COMPLEMENTARY DNA; HIGH TEMPERATURE REQUIREMENT A PROTEASE; IMMUNOGLOBULIN G ANTIBODY; PARASITE ANTIBODY; PDZ PROTEIN; RECOMBINANT PROTEIN; REGULATOR PROTEIN; SERINE PROTEINASE; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; BRUGIA; CALCULATION; CATALYSIS; CONTROLLED STUDY; CYTOPLASM; DATA BASE; DEVELOPMENTAL STAGE; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; ENDOCYTOBIOSIS; GENETIC CODE; GENOME ANALYSIS; HOST PARASITE INTERACTION; HUMAN; HUMAN TISSUE; IMMUNE SYSTEM; MICROFILARIA; MOLECULAR RECOGNITION; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; OOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SECRETION; RICKETTSIA PROWAZEKII; SEQUENCE HOMOLOGY; SUBCUTANEOUS TISSUE; UNINDEXED SEQUENCE; WOLBACHIA; ZYGOTE;

AMINO ACID SEQUENCE; ANIMALS; MOLECULAR SEQUENCE DATA; ONCHOCERCA VOLVULUS; PERIPLASM; SERINE ENDOPEPTIDASES; SYMBIOSIS; WOLBACHIA;

BRUGIA; BRUGIA MALAYI; DROSOPHILA MELANOGASTER; FILARIA; HYPODERRIS; MELANOGASTER; NEMATODA; ONCHOCERCA; ONCHOCERCA VOLVULUS; ORYCTOLAGUS CUNICULUS; RICKETTSIA; RICKETTSIA PROWAZEKII; WOLBACHIA;

EID: 1442348334     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2003.10.013     Document Type: Article

References (40)

1. Expert Committee on Onchocerciasis W.H.O. Third report. Wld. Hlth. Org. Tech. Rep. Ser. 752:1987;1-167.
2. Stouthamer R., Breeuwer J.A., Hurst G.D. Wolbachia pipientis: microbial manipulator of arthropod reproduction. Annu. Rev. Microbiol. 53:1999;71-102.
3. Bandi C., Trees A.J., Brattig N.W. Wolbachia in filarial nematodes: evolutionary aspects and implications for the pathogenesis and treatment of filarial diseases. Vet. Parasitol. 98:2001;215-238.
4. Bandi C., Anderson T.J.C., Genchi C., Blaxter M.L. The Wolbachia endosymbionts of filarial nematodes. Kennedy M.W., Harnett W. Parasitic Nematodes: Molecular Biology, Biochemistry and Immunology. 2001;25-43 CABI Publishing, Wallingford, UK.
5. Hoerauf A., Mand S., Volkmann L., Büttner M., Marfo-Debrekyei Y., Taylor M., Adjei O., Büttner D.W. Doxycycline in the treatment of human onchocerciasis: kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms. Microbes Infect. 5:2003;261-273.
6. Fischer P., Bonow I., Büttner D.W., Kamal I.H., Liebau E. An aspartate aminotransferase of Wolbachia endobacteria from Onchocerca volvulus is recognized by IgG1 antibodies from residents of endemic areas. Parasitol. Res. 90:2003;38-47.
7. Braig H.R., Zhou W., Dobson S.L., O'Neill S.L. Cloning and characterization of a gene encoding the major surface protein of the bacterial endosymbiont Wolbachia pipientis. J. Bacteriol. 180:1998;2373-2378.
8. Bazzocchi C., Jamnongluk W., O'Neill S.L., Anderson T.J., Genchi C., Bandi C. wsp gene sequences from the Wolbachia of filarial nematodes. Curr. Microbiol. 41:2000;96-100.
9. Pallen M.J., Wren B.M. The HtrA family of serine proteases. Mol. Microbiol. 26:1997;209-221.
10. Clausen T., Southan C., Ehrmann M. The HtrA family of proteases: implications for protein composition and cell fate. Mol. Cell. 10:2002;443-455.
11. Young J.C., Hartl F.U. A stress sensor for the bacterial periplasm. Cell. 113:2003;1-2.
12. Elzer P.H., Phillips R.W., Robertson G.T., Roop R.M. II. The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes. Infect. Immun. 64:1996;4838-4841.
13. Resto-Ruiz S.I., Sweger D., Widen R.D., Valkov N., Anderson B.E. Transcriptional activation of the HtrA (High-temperature requirement A) gene from Bartonella henselae. Infect. Immun. 68:2000;5970-5978.
14. Strauch K.L., Beckwith J. An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins. Proc. Natl. Acad. Sci. USA. 85:1988;1576-1580.
15. Henrik N., Engelbrecht J., Brunak S., Heijne G.V. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Engineering. 10:1997;1-6.
16. Falquet L., Pagni M., Bucher P., Hulo N., Sigrist C.J., Hofmann K., Bairoch A. The PROSITE database, its status in 2002. Nucleic Acids Res. 30:2002;235-238.
17. Büttner D.W., Albiez E.J., von Essen J., Erichsen J. Histological examination of adult Onchocerca volvulus and comparison with the collagenase technique. Trop. Med. Parasitol. 39:1988;390-417.
18. Fischer P., Kipp W., Bamuhiga J., Binta-Kahwa J., Kiefer A., Büttner D.W. Parasitological and clinical characterization of Simulium neavei-transmitted onchocerciasis in western Uganda. Trop. Med. Parasitol. 44:1993;311-321.
19. Hoerauf A., Mand S., Ohene A., Fleischer B., Büttner D.W. Depletion of Wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment. Lancet. 357:2001;1415-1416.
20. Taylor M.J., Hoerauf A. Wolbachia bacteria of filarial nematodes. Parasitol. Today. 15:1999;437-442.
21. Plenge-Bönig A., Krömer M., Büttner D.W. Light and electron microscopy studies on Onchocerca jakutensis and O. flexuosa of red deer show different host-parasite interactions. Parasitol. Res. 81:1995;66-73.
22. Brattig N.W., Krawietz I., Abakar A.Z., Erttmann K.D., Kruppa T.F., Massougbodji A. Strong IgG isotypic antibody response in sowdah type onchocerciasis. J. Infect. Dis. 170:1994;955-961.
23. Mpagi J.L., Büttner D.W., Tischendorf F.W., Erttmann K.D., Brattig N.W. Humoral responses to a secretory Onchocerca volvulus protein: differences in the pattern of antibody isotypes to recombinant Ov20/OvS1 in generalized and hyperreactive onchocerciasis. Parasite Immunol. 22:2000;455-460.
24. Brattig N.W., Henkle-Dührsen K., Hounkpatin S., Kruppa T., Liebau E., Zipfel P.F. Characterization of the human immune responses to the cytosolic superoxide dismutase and glutathione S-transferase from Onchocerca volvulus. Trop. Med. Int. Health. 2:1997;788-798.
25. Brenner S. The molecular evolution of genes and proteins: a tale of two serines. Nature. 334:1988;528-530.
26. Von Heijne G. A new method for predicting signal sequence cleavage sites. Nucl. Acids Res. 14:1986;4683-4690.
27. Büttner D.W., Wanji S., Bazzocchi C., Bain O., Fischer P. Obligatory symbiotic Wolbachia endobacteria are absent from Loa loa. Filaria J. 2:2003;10-19.
28. Miller H.R., Pemberton A.D. Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunology. 105:2002;375-390.
29. Langworthy N.G., Renz A., Mackenstedt U., Henkle-Dührsen K., de Bronsvoort M.B., Tanya V.N., Donnelly M.J., Trees A.J. Macrofilaricidal activity of tetracycline against the filarial nematode Onchocerca ochengi: elimination of Wolbachia precedes worm death and suggests a dependent relationship. Proc. R. Soc. Lond. B Biol. Sci. 267:2000;1063-1069.
30. Rao M.B., Tanksale A.M., Ghatge M.S., Deshpande V.V. Molecular and biotechnological aspects of microbial proteases. Microbiol. Mol. Biol. Rev. 62:1998;597-635.
31. Koonin E.V., Aravind L. Origin and evolution of eukaryotic apoptosis: the bacterial connection. Cell Death Differ. 9:2002;394-404.
32. Cianciotto N.P. Pathogenicity of Legionella pneumophila. Int. J. Med. Microbiol. 291:2001;331-343.
33. Krojer T., Garrido-Franco M., Huber R., Ehrmann M., Clausen T. Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine. Nature. 416:2002;455-459.
34. Day C.L., Hinds M.G. HtrA - a renaissance protein. Structure. 10:2002;737-739.
35. Harris B.Z., Lim W.A. Mechanism and role of PDZ domains in signaling complex assembly. J. Cell Sci. 114:2001;3219-3231.
36. Liu Q.A., Hengartner M.O. The molecular mechanism of programmed cell death in C. elegans. Ann. N.Y. Acad. Sci. 887:1999;92-104.
37. Erttmann K.D., Domeyer A., Gallin M. The putatively protective Onchocerca volvulus neuronal protein E1 is a member of the death domain protein family. FEBS Lett. 390:1996;21-24.
38. Maizels R.M., Blaxter M.L., Scott A.L. Immunological genomics of Brugia malayi: filarial genes implicated in immune evasion and protective immunity. Parasite Immunol. 23:2001;327-344.
39. Zang X., Yazdanbakhsh M., Jiang H., Kanost M.R., Maizels R.M. A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases. Blood. 94:1999;1418-1428.
40. Stanley P., Stein P.E. BmSPN2, a serpin secreted by the filarial nematode Brugia malayi, does not inhibit human neutrophil proteinases but plays a noninhibitory role. Biochemistry. 42:2003;6241-6248.