Transcriptional Regulation of Human Sodium/Iodide Symporter Gene: A Role for Redox Factor-1

Endocrinology

Volumn 145, Issue 3, 2004, Pages 1290-1293

  Puppin, Cinzia ^a   Arturi, Franco ^b   Ferretti, Elisabetta ^c   Russo, Diego ^b   Sacco, Rosario ^b   Tell, Gianluca ^a   Damante, Giuseppe ^a   Filetti, Sebastiano ^c,d  

^a UNIVERSITY OF UDINE   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d POLICLINICO UMBERTO I   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COTRANSPORTER; REDOX EFFECTOR FACTOR 1; TRANSCRIPTION FACTOR PAX8;

ARTICLE; CELL LINE; CONTROLLED STUDY; GENE; GENE CONTROL; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOLECULAR MECHANICS; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; SODIUM IODIDE SYMPORTER GENE; THYROPEROXIDASE GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION;

DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); SYMPORTERS; THYROID NEOPLASMS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 1442348110     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1250     Document Type: Article

References (33)

1. Schlumberger M 1998 Papillary and follicular thyroid carcinoma. N Engl J Med 338:297-306
2. Filetti S, Bidart JM, Arturi F, Caillou B, Russo D, Schlumberger M 1999 Sodium/iodide symporter: a key transport system in thyroid cancer cell metabolism. Eur J Endocrinol 141:443-457
3. Dohan O, De La Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginger CS, Carrasco N 2003 The sodium/iodide symporter (NIS): characterization, regulation, and medical significance. Endocr Rev 24:48-77
4. Spitzweg C, Harrington KJ, Pinke LA, Vile RG, Morris JC 2001 Clinical review 132: the sodium/iodide symporter and its potential role in cancer therapy. J Clin Endocrinol Metab 86:3327-3335
5. Shen DH, Kloos RT, Mazzaferri EL, Jhiang SM 2001 Sodium/iodide symporter in health and disease. Thyroid 11:415-425
6. Ryu KY, Tong Q, Jhiang SM 1998 Promoter characterization of the human Na+/I-symporter. J Clin Endocrinol Metab 83:3247-3251
7. Behr M, Schmitt TL, Espinoza CR, Loos U 1998 Cloning of a functional promoter of the human sodium/iodide-symporter gene. Biochem J 331: 359-363
8. - symporter gene promoter. Horm Metab Res 32:1-5
9. Schmitt TL, Espinoza CR, Loos U 2001 Transcriptional regulation of the human sodium/iodide symporter gene by Pax8 and TTF-1. Exp Clin Endocrinol Diabetes 109:27-31
10. Taki K, Kogai T, Kanamoto Y, Hershman JM, Brent GA 2002 A thyroid-specific far-upstream enhancer in the human sodium/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3′, 5′- monophosphate response element-like sequence binding proteins for full activity and is differentially regulated in normal and thyroid cancer cells. Mol Endocrinol 16:2266-2282
11. Schmutzler C, Schmitt TL, Glaser F, Loos U, Kohrle J 2002 The promoter of the human sodium/iodide-symporter gene responds to retinoic acid. Mol Cell Endocrinol 189:145-155
12. Xu J, Kogai T, Brent GA, Hershman JM 2002 A GC box in the human sodium iodide symporter gene promoter is essential for full activity. Thyroid 12: 107-114
13. Schmitt TL, Espinoza CR, Loos U 2002 Characterization of a thyroid-specific and cyclic adenosine monophosphate-responsive enhancer far upstream from the human sodium iodide symporter gene. Thyroid 12:273-279
14. Chiefari E, Brunetti A, Arturi F, Bidart J-M, Russo D, Schlumberger M, Filetti S 2002 Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation? BMC Cancer 2:35
15. Evans AR, Limp-Foster M, Kelley MR 2000 Going APE over ref-1. Mutat Res 461:83-108
16. Tell G, Pellizzari L, Cimarosti D, Pucillo C, Damante G 1998 Ref-1 controls Pax-8 DNA-binding activity. Biochem Biophys Res Commun 252:178-183
17. Francis-Lang H, Zannini M, De Felice M, Berlingieri MT, Fusco A, Di Lauro R 1992 Multiple mechanisms of interference between transformation and differentiation in thyroid cells. Mol Cell Biol 12:5793-5800
18. Huang RP, Liu C, Fan Y, Mercola D, Adamson ED 1995 Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain. Cancer Res 55:5054-5062
19. Ambesi-Impiombato FS, Coon HG 1979 Thyroid cells in culture. Int Rev Citol Suppl 10:163-172
20. Visconti R, Cerutti J, Battista S, Fedele M, Trapasso F, Zeki K, Miano MP, de Nigris F, Casalino L, Curcio F, Santoro M, Fusco A 1997 Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFκB p65 protein expression. Oncogene 15:1987-1994
21. Tell G, Pellizzari L, Pucillo C, Puglisi F, Cesselli D, Kelley MR, Di Loreto C, Damante G 2000 TSH controls Ref-1 nuclear translocation in thyroid cells. J Mol Endocrinol 24:383-390
22. Russo D, Arturi F, Bulotta S, Pellizzari L, Filetti S, Mancini G, Damante G, Tell G 2001 Ape1/Ref-1 expression and cellular localization in human thyroid carcinoma cell lines. J Endocrinol Invest 24:RC10-RC12
23. Lazar V, Bidart JM, Caillou B, Mahé C, Lacroix L, Filetti S, Schlumberger M 1999 Expression of the Na+/I-symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J Clin Endocrinol Metab 84:3228-3234
24. Huang RP, Adamson ED 1993 Characterization of the DNA-binding properties of the early growth response-1 (Egr-1) transcription factor: evidence for modulation by a redox mechanism. DNA Cell Biol 12:265-273
25. Arturi F, Russo D, Bidart JM, Scarpelli D, Schlumberger M, Filetti S 2001 Expression pattern of the pendrin and sodium/iodide symporter genes in human thyroid carcinoma cell lines and human thyroid tumors. Eur J Endocrinol 145:129-135
26. Kogai T, Hershman JM, Motomura K, Endo T, Onaya T, Brent GA 2001 Differential regulation of the human sodium/iodide symporter gene promoter in papillary thyroid carcinoma cell lines and normal thyroid cells. Endocrinology 142:3369-3379
27. Fabien N, Fusco A, Santoro M, Barbier Y, Dubois P-M, Paulin C 1994 Description of a human papillary thyroid carcinoma cell line. Cancer 73:2206-2212
28. - symporter and iodine accumulation in poorly differentiated thyroid carcinoma cells. J Clin Endocrinol Metab 86:3430-3435
29. Zarnegar R, Brunaud L, Kanauchi H, Wong M, Fung M, Ginzinger D, Duh Q-Y, Clark OH 2002 Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. Surgery 136:984-990
30. - symporter gene methylation status. J Clin Endocrinol Metab 84: 2449-2457
31. Schmutzler C, Winzer R, Meissner-Weigl J, Kohrle J 1997 Retinoic acid increases sodium/iodide symporter mRNA levels in human thyroid cancer cell lines and suppresses expression of functional symporter in nontransformed FRTL-5 rat thyroid cells. Biochem Biophys Res Commun 240:832-838
32. Gruning T, Tiepolt C, Zophel K, Bredow J, Kropp J, Franke WG 2003 Retinoic acid for redifferentiation of thyroid cancer - does it hold its promise? Eur J Endocrinol 148:395-402
33. Nunez J, Pommier J 1982 Formation of thyroid hormones. Vitam Horm 39:175-229