Interleukin-6 response to exercise during acute and chronic hypoxia

European Journal of Applied Physiology

Volumn 91, Issue 1, 2004, Pages 88-93

  Lundby, Carsten ^a   Steensberg, Adam ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Absolute; Altitude; Catecholamines; Exercise; Relative

Indexed keywords

CATECHOLAMINE; INTERLEUKIN 6;

ADULT; ALTITUDE ACCLIMATIZATION; ARTICLE; BICYCLE ERGOMETRY; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; CORRELATION COEFFICIENT; DENMARK; EXERCISE; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; HYPOXIA; IMMUNE RESPONSE; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REGULATORY MECHANISM; SEA LEVEL; WORKLOAD;

ADULT; ALTITUDE; ANOXIA; CATECHOLAMINES; CHRONIC DISEASE; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; INTERLEUKIN-6; MALE; OXYGEN CONSUMPTION; WORKLOAD;

EID: 1442301566     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-003-0935-y     Document Type: Article

References (32)

1. Bruunsgaard H, Skinhøj P, Quist J, Pedersen BK (1999) Elderly humans show prolonged in vivo inflammatory activity during pneumococcal infections. J Infect Dis 180:551-554
2. Christensen EH, Hansen O (1939) Respiratorische quotient - Bestimmungen in Ruhe und bei Arbeit. Skand Arch Physiol 81:137-151
3. DeRijk RH, Boelen A, Tilders FJ, Berkenbosch F (1994) Induction of plasma interleukin-6 by circulating adrenalin in the rat. Psychoneuroendocrinology 19:155-163
4. Dill DB, Edwards HT, Fölling A, Oberg SA, Pappenheimer AM, Talbott JH (1931) Adaptations of the organism to changes in oxygen pressure. J Physiol (Lond) 71:47-63
5. Febbrario MA, Keenan J, Angus DJ, Campbel SE, Garovoy MR (2000) Preexercise carbohydrate ingestion, glucose kinetics, and muscle glycogen use: effect of the glycemic index. J Appl Physiol 89(5):1845-1851
6. Hartmann G, Tschöp M, Fischer R, Bidlingmaier C, Riepl R, Tschöp K, Hautmann H, Enders S, Toepfer M (2000) High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and c-reactive protein. Cytokine 12:246-252
7. Klausen T, Olsen NV, Poulsen TD, Richalet JP, Pedersen BK (1997) Hypoxemia increases serum interleukin-6 in humans. Eur J Appl Physiol 76:480-482
8. Kleger GR, Bartsch P, Vock P HB, Roberts LJ 2nd, Balsamo V (1996) Evidence against an increase in capillary permeability in subjects exposed to high altitude. J Appl Physiol 81(5):1917-1923
9. Kubo K, Hanaoka M, Yamaguchi S, Hayona T, Hayasaka M, Koizumi T, Fujimoto K, Kobayashi T, Honda T (1996) Cytokines in bronchoalveolar lavage fluid in patients with high altitude pulmonary oedema at moderate altitude in Japan. Thorax 51:739-742
10. Langberg H, Olesen JL, Gemmer C, Kjaer M (2002) Substantial elevation of interleukin-6 concentrations in peritendinous, but not muscle, following prolonged exercise. J Physiol (Lond) 542:985-990
11. Lundby C, van Hall G (2002) Submaximal substrate utilization is unaffected by acute and chronic hypoxia when expressed relatively to maximal oxygen uptake. Acta Physiol Scand 176:195-201
12. Lyngsø D, Simonsen L, Bülow J (2002) Interleukin-6 production in human subcutaneous abdominal adipose tissue: effect of exercise. J Physiol (Lond) 543:1033-1046
13. Maggiorini M, Swenson E, Mairbaurl H, Joller-Jemelka H, Gibbs S, Bärtsch P (2000) Plasma interleukin-6 a marker of injury to the blood-gas barrier in high altitude pulmonary edema. Abstract 117 at the IV World Congress on Mountain Medicine and High Altitude Physiology, Arica, Chile
14. Mazzeo RS, Bender PR, Brooks GA, Butterfield GE, Groves BM, Sutton JR, Wolfel EE, Reeves JT (1991) Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure. Am J Physiol 261:E419-E424
15. Mazzeo RS, Brooks GA, Butterfield GE, Podolin DA, Wolfel EE, Reeves JT (1995) Acclimatization to high altitude increases muscle sympathetic activity both at rest and during exercise. Am J Physiol 269:R201-R207
16. Mazzeo RS, Child A, Butterfield GE, Mawson JT, Zamundio S, Moore LG (1998) Catecholamine response during 12 days of high-altitude exposure (4,300 m) in women. J Appl Physiol 84:1151-1155
17. Mazzeo RS, Child A, Butterfield GE, Braun B, Rock PB, Wolfel EE, Zamudio S, Moore LG (2000a) Sympathoadrenal responses to submaximal exercise in women after acclimatization to 4,300 Meters. Metabolism 49:1036-1042
18. Mazzeo RS, Donovan D, Fleshner M, Butterfield GE, Zamudio S, Wolfel EE, Moore LG (2000b) Interleukin-6 response to exercise and high-altitude exposure: influence of α-adrenergic blockade. J Appl Physiol 91:2143-2149
19. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW (1997) Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 82:4196-4200
20. Nielsen HB, Secher N, Perdersen BK (1996) Lymphocytes and NK cell activity during repeated bouts of maximal exercise. Am J Physiol 271:R222-R227
21. Nybo L, Nielsen B, Pedersen BK, Møller K, Secher NH (2002) Interleukin-6 release from human brain during exercise. J Physiol (Lond) 542:991-995
22. Ostrowsky K, Schjerling P, Pedersen BK (2000) Physical activity and plasma interleukin-6 in humans-effect of intensity of exercise. Eur J Appl Phys 83:512-515
23. Papanicolaou DA, Petrides JS, Tsigos C, Bina S, Kalogeras KT, Wilder R (1996) Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol 271(3 Pt 1):E601-E605
24. Pavlicek V, Marti HH, Grad S, Gibbs JSR, Kol C, Wenger RH, Gassmann M, Kohl J, Maly FE, Oelz O, Koller EA, Schirlo C (2000) Effects of hypobaric hypoxia on vascular endothelial growth factor and the acute phase response in subjects who are susceptible to high-altitude pulmonary oedema. Eur J Appl Physiol 81:497-503
25. Pedersen BK, Steensberg A, Schjerling P (2001) Muscle-derived interleukin-6: possible biological effects. J Physiol (Lond) 536:329-339
26. Savourey G, Launay JC, Besnard Y, Guinet A, Travers S (2003) Normo- and hypobaric hypoxia: are there any physiological differences ? Eur J Appl Physiol 89:122-126
27. Starkie RL, Rolland J, Angus DJ, Aanderson MJ, Febbraio MA (2001a) Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-alpha levels after prolonged running. Am J Physiol 280:C769-C774
28. Starkie RL, Arkinstall MJ, Koukoulas I, Hawley JA, Febbraio MA (2001b) Carbohydrate ingestion attenuates the increase in plasma interleukin 6, but not skeletal muscle interleukin 6 mRNA, during exercise in humans. J Physiol (Lond) 533(Pt 2):585-591
29. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, Pedersen BK (2000) Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol (Lond) 529.1:237-242
30. Steensberg A, Toft AD, Scherling P, Halkjaer-Kristensen J, Pedersen BK (2001a) Plasma interleukin-6 during strenuous exercise: role of epinephrine. Am J Physiol 281:C1001-C1004
31. Steensberg A, Febbraio MA, Osada T, van Hall G, Schjerling P, Saltin B, Pedersen BK (2001b) Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. J Physiol (Lond) 537.2:633-639
32. van Gool J, van Vugt H, Helle M, Aarden LA (1990) The relation among stress, adrenalin, interleukin 6 and acute phase proteins in the rat. Clin Immunol Immunopathol 57:200-210