Lymphocytes and NK cell activity during repeated bouts of maximal exercise

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 271, Issue 1 40-1, 1996, Pages

  Nielsen, Henning B ^a   Secher, Niels H ^b   Christensen, Niels J ^b   Pedersen, Bente K ^b  

^a Rigshospitalet   (Denmark)

^b NONE

Author keywords

cytokines; natural killer cells; rowing

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 6;

ADULT; ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; EXERCISE; GRANULOCYTE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNE SYSTEM; LYMPHOCYTE SUBPOPULATION; MALE; MONONUCLEAR CELL; NATURAL KILLER CELL; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

EID: 0029793784     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.271.1.r222     Document Type: Article

References (28)

1. Brahmi, Z., J. E. Thomas, M. Park, M. Park, and I. R. Dowdeswell. The effect of acute exercise on natural killer-cell activity of trained and sedentary human subjects. J. Clin. Immunol. 5: 321-328, 1985.
2. Cannon, J. G., W. J. Evans, V. A. Hughes, C. N. Meredith, and C. A. Dinarello. Physiological mechanisms contributing to increased interleukin-1 secretion. J. Appl. Physiol. 61: 1869-1874, 1986.
3. Cannon, J. G., R. A. Fielding, M. A. Fiatarone, S. F. Orencole, C. A. Dinarello, and W. J. Evans. Increased interleukin 1β in human skeletal muscle after exercise. Am. J. Physiol. 257 (Regulatory Integrative Camp. Physiol. 26): R451-R455, 1989.
4. Deuster, P. A., A. M. Curiale, M. L. Cowan, and F. D. Finkelman. Exercise-induced changes in populations of peripheral blood monomiclear cells. Med. Sci. Sports Exercise 20: 276-280, 1988.
5. Edwards, A. J., T. H. Bacon, C. A. Elms, R. Verardi, M. Felder, and S. C. Knight. Changes in the populations of lymphoid cells in human peripheral blood following physical exercise. Clin. Exp. Immunol. 58: 420-427, 1984.
6. Espersen, G. T., A. Elbaek, E. Ernst, E. Toft, S. Kaalund, C. Jersild, and N. Grunnet. Effect of physical exercise on cytokines and lymphocyte subpopulations in human peripheral blood. APMIS 98: 395-400, 1990.
7. Fiatarone, M. A., J. E. Morley, E. T. Bloom, D. Benton, T. Makinodan, and G. F. Solomon. Endogenous opioids and the exercise-induced augmentation of natural killer cell activity. J. Lab. Clin. Med. 112: 544-552, 1988.
8. Field, C. J., R. Gougeon, and E. B. Marliss. Circulating mononuclear cell numbers and function during intense exercise and recovery. J. Appl. Physiol. 71: 1089-1097, 1991.
9. Fry, R. W., A. R. Morton, and D. Keast. Acute intensive interval training and T-lymphocyte function. Med. Sci. Sports Exercise 24: 339-345, 1992.
10. Gabriel, H., A. Urhausen, and W. Kindermann. Circulating leucocyte and lymphocyte subpopulations before and after intensive endurance exercise to exhaustion. Eur. J. Appl. Physiol. 63: 449-457, 1991.
11. Hedfors, E., G. Holm, M. Ivansen, and J. Wahren. Physiological variation of blood lymphocyte reactivity: T-cell subsets, immunoglobulin production, and mixed-lymphocyte reactivity. Clin. Immunol. Immunopathol. 27: 9-14, 1983.
12. Hoffman-Goetz, L., J. R. Simpson, N. Cipp, Y. Arumugam, and M. E. Houston. Lymphocyte subset responses to repeated submaximal exercise in men. J. Appl. Physiol. 68: 1069-1074, 1990.
13. Holmquist, N., N. H. Secher, K. Sander-Jensen, U. Knigge, J. Warberg, and T. W. Schwartz. Sympathoadrenal and parasympathic responses to exercise. J. Sports Med. 4: 123-128, 1986.
14. Jensen, K., T. S. Nielsen, Å. Fiskestrand, J. O. Lund, N. J. Christensen, and N. H. Secher. High-altitude training does not increase maximal oxygen uptake or work capacity at sea level in rowers. Scand. J. Med. Sci. Sports 3: 256-262, 1993.
15. Kappel, M., N. Tvede, H. Galbo, P. M. Haahr, M. Kjaer, M. Linstow, K. Klarlund, and B. K. Pedersen. Evidence that the effect of physical exercise on NK cell activity is mediated by epinephrine. J. Appl. Physiol. 70: 2530-2534, 1991.
16. Kjaer, M., N. H. Secher, F. W. Bach, and H. Galbo. Role of motor center activity for hormonal changes and substrate mobilization in humans. Am. J. Physiol. 253 (Regulatory Integrative Comp. Physiol. 22): R687-R695, 1987.
17. Nielsen, H. B., N. H. Secher, M. Kappel, B. Hanel, and B. K. Pedersen. Lymphocyte, NK, and LAK cell responses to maximal exercise. Int. J. Sports Med 17: 60-65, 1996.
18. Nieman, D. C., L. S. Berk, W. M. Simpson, K. Arabatzis, S. Youngberg, S. A. Tan, J. W. Lee, and W. C. Eby. Effects of long-endurance running on immune system parameters and lymphocyte function in experienced marathoners. Int. J. Sports Med. 10: 317-323, 1989.
19. Nieman, D. C., D. A. Henson, R. Johnson, L. Lebeck, J. M. Davis, and C. S. Nehlsen. Effects of brief, heavy exertion on circulating lymphocyte subpopulations and proliferative response. Med. Sci. Sports Exercise 24: 1339-1345, 1992.
20. Nieman, D. C., C. S. Nehlsen, K. M. Donohue, D. B. Chritton, B. L. Haddock, R. W. Stout, and J. W. Lee. The effects of acute moderate exercise on leukocyte and lymphocyte subpopulations. Med. Sci. Sports Exercise 23: 578-585, 1991.
21. Northoff, H., and A. Berg. Immunologic mediators as parameters of the reaction to strenuous exercise. Int. J. Sports Med. 12: 9-15, 1991.
22. Pedersen, B. K., K. Kappel, M. Klokker, H. B. Nielsen, and N. H. Secher. The immune system during exposure to extreme physiologic conditions. Int. J. Sports Med. 15: S116-S121, 1994.
23. Pedersen, B. K., N. Tvede, F. R. Hansen, V. Andersen, T. Bendix, G. Bendixen, K. Bendtzen, H. Galbo, P. M. Haahr, K. Klarlund, J. Sylvest, B. S. Thomsen, and J. Halkjaer-Kristensen. Modulation of natural killer cell activity in peripheral blood by physical exercise. Scand. J. Immunol. 27: 673-678, 1988.
24. Pedersen, B. K., N. Tvede, K. Klarlund, L. D. Christensen, F. R. Hansen, H. Galbo, A. Kharazmi, and K. J. Halkjaer. Indomethacin in vitro and in vivo abolishes post-exercise suppression of natural killer cell activity in peripheral blood. Int. J. Sports Med. 11: 127-131, 1990.
25. Shinkai, S., S. Shore, P. N. Shek, and R. J. Shephard. Acute exercise and immune function. Relationship between lymphocyte activity and changes in subset counts. Int. J. Sports Med. 13: 452-461, 1992.
26. Tvede, N., M. Kappel, K. J. Halkjaer, H. Galbo, and B. K., Pedersen. The effect of light, moderate and severe bicycle exercise on lymphocyte subsets, natural and lymphokine activated killer cells, lymphocyte proliferative response and interleukin 2 production. Int. J. Sports Med. 14: 275-282, 1993.
27. Tvede, N., J. Steensberg, B. Baslund, J. Halkjaer-Kristensen, and B. K. Pedersen. Cellular immunity in highly-trained elite racing cyclists and controls during periods of training with high and low intensity Scand. J. Med. Sci. Sports 1: 163-166, 1991.
28. Ullum, H., P. M. Haahr, M. Diamant, J. Palmo, J. Halkjaer-Kristensen, and B. K. Pedersen. Bicycle exercise enhances plasma-IL-6, but does not change IL-1α, IL-1β, or TNF-α pre-mRNA in BMNC. J. Appl. Physiol. 77: 93-97, 1994.