Synthesis of [Gly-1]RA-VII, [Gly-2]RA-VII, and [Gly-4]RA-VII. Glycine-Containing Analogues of RA-VII, an Antitumor Bicyclic Hexapeptide from Rubia Plants

Journal of Organic Chemistry

Volumn 69, Issue 5, 2004, Pages 1481-1486

  Hitotsuyanagi, Yukio ^a   Hasuda, Tomoyo ^a   Aihara, Takayuki ^a   Ishikawa, Hiroshi ^a   Yamaguchi, Kentaro ^b   Itokawa, Hideji ^a   Takeya, Koichi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; DEGRADATION; PLANTS (BOTANY); SYNTHESIS (CHEMICAL);

CYTOTOXIC ACTIVITY; MACROCYCLIZATION;

AMINO ACIDS;

ALANINE; ANTINEOPLASTIC AGENT; GLYCINE DERIVATIVE; HEXAPEPTIDE; PLANT EXTRACT; TETRAPEPTIDE; TYROSINE DERIVATIVE;

ARTICLE; CYCLIZATION; CYTOTOXICITY; DRUG CONFORMATION; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; RUBIACEAE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BICYCLO COMPOUNDS; CELL SURVIVAL; CYCLIZATION; GLYCINE; MICE; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; RUBIA; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 1442300005     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo030293p     Document Type: Article

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