3-Monochloropropane-1,2-diol does not cause neurotoxicity in vitro or neurobehavioral deficits in rats

NeuroToxicology

Volumn 25, Issue 3, 2004, Pages 377-385

  Kim, Kisok ^a   Song, Chiwon ^a   Park, Younjoo ^a   Koh, Seongho ^a   Kim, Juwhan ^a   Kim, Sunyoun ^a   Kim, Youngchul ^a   Kim, Seung U ^b   Jung, Haikwan ^a  

^a National Institute of Toxicological Research   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

3 MCPD; Grip strength; Landing foot splay; Motor activity; N18D3; PC12

Indexed keywords

3 MONOCHLOROPROPANE 1,2 DIOL; ACRYLAMIDE; PROPANEDIOL DERIVATIVE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BODY WEIGHT; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; IN VITRO STUDY; MALE; MOTOR ACTIVITY; MUSCLE WEAKNESS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLYCEROL; MALE; MOTOR ACTIVITY; MOTOR SKILLS; PC12 CELLS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 1442287624     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2003.08.004     Document Type: Article

References (30)

1. Al Deeb S., Al Moutaery K., Arshaduddin M., Biary N., Tariq M. Attenuation of acrylamide-induced neurotoxicity in diabetic rats. Neurotoxicol. Teratol. 22:2000;247-253.
2. Ban Y., Asanabe U., Inagaki S., Sasaki M., Nakatsuka T., Matsumoto H. Effects of alpha-chlorohydrin on rat sperm motions in relation to male reproductive functions. J. Toxicol. Sci. 24:1999;407-413.
3. Cavanagh J.B., Nolan C.C. The neurotoxicity of alpha-chlorohydrin in rats and mice: II. Lesion topography and factors in selective vulnerability in acute energy deprivation syndromes. Neuropathol. Appl. Neurobiol. 19:1993;471-479.
4. Cavanagh J.B., Nolan C.C., Seville M.P. The neurotoxicity of alpha-chlorohydrin in rats and mice: I. Evolution of the cellular changes. Neuropathol. Appl. Neurobiol. 19:1993;240-252.
5. Crews C., Brereton P., Davies A. The effects of domestic cooking on the levels of 3-monochloropropanediol in foods. Food Addit. Contam. 18:2001;271-280.
6. Crews C., Hough P., Brereton P., Harvey D., Macarthur R., Matthews W. Survey of 3-monochloropropane-1,2-diol (3-MCPD) in selected food groups 1999-2000. Food Addit. Contam. 19:2002;22-27.
7. Edwards P.M., Parker V.H. A simple, sensitive, and objective method for early assessment of acrylamide neuropathy in rats. Toxicol. Appl. Pharmacol. 40:1977;589-591.
8. Edwards E.M., Jones A.R., Waites G.M. The entry of alpha-chlorohydrin into body fluids of male rats and its effect upon the incorporation of glycerol into lipids. J. Reprod. Fertil. 43:1975;225-232.
9. Ford W.C., Waites G.M. Activities of various 6-chloro-6-deoxysugars and (S)-alpha-chlorohydrin in producing spermatocoeles in rats and paralysis in mice and in inhibiting glucose metabolism in bull spermatozoa in vitro. J. Reprod. Fertil. 65:1982;177-183.
10. Hamlet C.G., Jayaratne S.M., Matthews W. 3-Monochloropropane-1,2-diol (3-MCPD) in food ingredients from UK food producers and ingredient suppliers. Food. Addit. Contam. 19:2002;15-21.
11. Jelks K., Berger T., Horner C., Miller M.G. alpha-chlorohydrin induced changes in sperm fertilizing ability in the rat: association with diminished sperm ATP levels and motility. Reprod. Toxicol. 15:2001;11-20.
12. JFSSG. Survey of 3-monochloropropane-1,2-diol (3-MCPD) in acid-hydrolysed vegetable protein. Food Surveillance Information Sheet No. 181; 1999.
13. Jin Q., Zhang Z., Luo R., Li J. Survey of 3-monochloropropane-1,2-diol in soy sauce and similar products. Wei Sheng Yan Jiu. 30:2001;60-61.
14. Jones A.R. The metabolism of 3-chloro-, 3-bromo- and 3-iodoprpan-1, 2-diol in rats and mice. Xenobiotica. 5:1975;155-165.
15. Jones A.R. The antifertility actions of alpha-chlorohydrin in the male. Life Sci. 23:1978;1625-1645.
16. Jones A.R. Antifertility actions of alpha-chlorohydrin in the male. Aust. J. Biol. Sci. 36:1983;333-350.
17. Jones A.R., Milton D.H., Murcott C. The oxidative metabolism of alpha-chlorohydrin in the male rat and the formation of spermatocoeles. Xenobiotica. 8:1978;573-582.
18. Kakaria VK. Effect of chemosterilants on the nervous and reproductive systems of albino mice. PhD thesis, Saurashtra University, Rajkot 1983.
19. Kakaria V.K., Sood P.P. Qualitative and quantitative changes of acetylcholinesterase in the central nervous system of mice during low and high dose treatment of alpha-chlorohydrin. Cell Mol. Biol. 31:1985;139-148.
20. Kaur S., Guraya S.S. Biochemical observations on the protein and nucleic acid metabolism of the rat testis and epididymis after treatment with low doses of alpha-chlorohydrin. Int. J. Fertil. 26:1981;8-13.
21. Kluwe W.M., Gupta B.N., Lamb J.C.4th. The comparative effects of 1,2-dibromo-3-chloropropane (DBCP) and its metabolites, 3-chloro-1,2- propaneoxide (epichlorohydrin), 3-chloro-1,2-propanediol (alphachlorohydrin), and oxalic acid, on the urogenital system of male rats. Toxicol. Appl. Pharmacol. 70:1983;67-86.
22. Macarthur R., Crews C., Davies A., Brereton P., Hough P., Harvey D. 3-monochloropropane-1,2-diol (3-MCPD) in soy sauces and similar products available from retail outlets in the UK. Food Addit. Contam. 17:2000;903-906.
23. Park S.A., Choi K.S., Bang J.H., Huh K., Kim S.U. Cisplatin-induced apoptotic cell death in mouse hybrid neurons is blocked by antioxidants through suppression of cisplatin-mediated accumulation of p53 but not of Fas/Fas ligand. J. Neurochem. 75:2000;946-953.
24. Romero I.A., Rist R.J., Chan M.W., Abbott N.J. Acute energy deprivation syndromes: investigation of m-dinitrobenzene and alpha-chlorohydrin toxicity on immortalized rat brain microvessel endothelial cells. Neurotoxicology. 18:1997;781-791.
25. Sheline C.T., Choi D.W. Neuronal death in cultured murine cortical cells is induced by inhibition of GAPDH and triosephosphate isomerase. Neurobiol. Dis. 5:1998;47-54.
26. Sood P.P., Kakaria V.K. Qualitative and quantitative measurements of adenosine triphosphatase changes in the brain of mice during low- and high-dose treatment with alpha-chlorohydrin. Cell Mol. Biol. 30:1984;509-518.
27. Sood P.P., Majid M.A. Qualitative and quantitative changes of acid and alkaline phosphatases in the testis and epididymis of mice in relation to single high dose of alpha-chlorohydrin. Acta Eur. Fertil. 18:1987;33-38.
28. Sunahare G, Perrin I, Marchessine M. Carcinogenicity study on 3-monochloropropane-1,2-diol (3-MCPD) administered in drinking water to Fisher 344 rats. Report RE-SR93003 submitted to WHO by Nestec Ltd., Research and Development, Lausanne, Switzerland; 1993.
29. Vickery B.H., Erickson G.I., Bennett J.P. Mechanism of antifertility action of low doses of alpha-chlorohydrin in the male rat. J. Reprod. Fertil. 38:1974;1-10.
30. Woods J., Garside D.A. An in vivo and in vitro investigation into the effects of alpha-chlorohydrin on sperm motility and correlation with fertility in the Han Wistar rat. Reprod. Toxicol. 10:1996;199-207.