Tamoxifen stimulates cancellous bone formation in long bones of female mice

Endocrinology

Volumn 146, Issue 3, 2005, Pages 1060-1065

  Perry, M J ^a   Gujra, S ^a   Whitworth, T ^a   Tobias, J H ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE GROWTH; CANCELLOUS BONE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; LONG BONE; METAPHYSIS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; SKELETON; TIBIA; UTERUS WEIGHT; WEIGHT GAIN;

ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DEVELOPMENT; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; MICE; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN; TIBIA; TIME FACTORS; TOLONIUM CHLORIDE; UTERUS;

EID: 14244266609     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-1114     Document Type: Article

References (38)

1. Tobias JH, Compston J 1999 Does estrogen stimulate osteoblast function in postmenopausal women? Bone 24:121-124
2. Khastgir G, Studd J, Holland N, Alaghband-Zadeh J, Fox S, Chow J 2001 Anabolic effect of estrogen replacement on bone in postmenopausal women with osteoporosis: histomorphometric evidence in a longitudinal study. J Clin Endocrinol Metab 86:289-295
3. Khastgir G, Studd JW, Fox SW, Jones J, Alaghband-Zadeh J, Chow JW 2003 A longitudinal study of the effect of subcutaneous estrogen replacement on bone in young women with Turner's syndrome. J Bone Miner Res 18:925-932
4. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH 2001 Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344:1434-1441
5. Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, Bonds D, Brunner R, Brzyski R, Caan B, Chlebowski R, Curb D, Gass M, Hays J, Heiss G, Hendrix S, Howard BV, Hsia J, Hubbell A, Jackson R, Johnson KC, Judd H, Kotchen JM, Kuller L, LaCroix AZ, et al. 2004 Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 291:1701-1712
6. Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, Christiansen C 1999 Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene. JAMA 282:637-645
7. Love RR, Mazees RB, Barden HS, Epstein S, Newcomb PA, Jordan VC, Carbone PP, DeMets DL 1992 Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. N Engl J Med 326:852-856
8. Delmas PD, Bjarnason NH, Mitlak BH, Ravoux A-C, Shah AS, Huster W, Draper M, Christiansen C1997 Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N Engl J Med 337:1641-1647
9. Marttunen MB, Hietanen P, Tiitinen A, Ylikorkala O 1998 Comparison of effects of tamoxifen and toremifene on bone biochemistry and bone mineral density in postmenopausal breast cancer patients. J Clin Endocrinol Metab 83:1158-1162
10. Ke HZ, Simmons HA, Pirie CM, Crawford DT, Thompson DD 1995 Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats. Endocrinology 136:2435-2441
11. Turner RT, Wakley GK, Hannon KS, Bell NH 1988 Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone-deficients rats. Endocrinology 122:1146-1150
12. Evans G, Bryant HU, Magee D, Sato M, Turner RT 1994 The effects of raloxifene on tibia histomorphomerry in ovariectomized rats. Endocrinology 134:2283-2288
13. Jimenez MA, Maghee DE, Bryant HU, Turner RT 1997 Clomiphene prevents cancellous bone loss from the tibia of ovariectomized rats. Endocrinology 138:1794-1800
14. Nuttall ME, Bradbeer JN, Stroup GB, Nadeau DP, Hoffman SJ, Zhao H, Rehm S, Gowen M 1998 Idoxifene: a novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats. Endocrinology 139:5224-5234
15. McDougall KE, Perry MJ, Gibson RL, Colley SM, Korach KS, Tobias JH 2003 Estrogen receptor-α dependency of estrogen's stimulatory action on cancellous bone formation in male mice. Endocrinology 144:1994-1999
16. Berry M, Metzger D, Chambon P 1990 Role of the two activating domains of onistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J 9:2811-2818
17. Qu Q, Harkonen PL, Vaananen HK 1999 Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture. J Cell Biochem 73:500-507
18. Taranta A, Brama M, Teti A, De luca V, Scandurra R, Spera G, Agnusdei D, Termine JD, Migliaccio S 2002 The selective estrogen receptor modulator raloxifene regulates osteoclast and osteoblast activity in vitro. Bone 30:368-376
19. Ong DB, Colley SM, Norman MR, Kitazawa S, Tobias JH 2004 Transcriptional regulation of a BMP-6 reporter by estrogen receptor α. J Bone Miner Res 19:447-454
20. Yang NN, Venugopalan M, Hardikar S, Glasebrook A 1996 Identification of an estrogen response element activated by metabolites of 17β-estradiol and raloxifene. Science 273:1222-1225
21. van den Wijngaard A, Mulder WR, Dijkema R, Boersma CJ, Mosselman S, van Zoelen EJ, Olijve W 2000 Antiestrogens specifically up-regulate bone morphogenetic protein-4 promoter activity in human osteoblastic cells. Mol Endocrinol 14:623-633
22. Tou L, Quibria N, Alexander JM 2001 Regulation of human cbfa1 gene transcriptio ni nosteoblasts by selective estrogen receptor modulators (SERMs). Mol Cell Endocrinol 183:71-79
23. Gardner WU, Pfeiffer CA 1937 Skeletal changes in mice receiving estrogen, Proc Soc Exp Biol Med 36:678-679
24. Urist MR, Budy AM, McLean FC 1950 Endosteal bone formation in estrogen-treated mice. J Bone Joint Surg 32A:143-162
25. Samuels A, Perry MJ, Tobias JH 1999 High-dose estrogen induces de novo medullary bone formation in female mice. J Bone Miner Res 14:178-186
26. Wolf DM, Langan-Fahey SM, Parker CJ, McCague R, Jordan VC 1993 Investigation of the mechanism of tamoxifen-stimulated breast tumor growth with nonisomerizable analogues of tamoxifen and metabolites. J Natl Cancer Inst 85:806-812
27. Samuels A, Perry MJ, Goodship AE, Fraser WD, Tobias JH 2000 Is high-dose estrogen-induced osteogenesis in the mouse mediated by an estrogen receptor? Bone 27:41-46
28. Broulik PD 2000 Tamoxifen prevents bone loss in castrated male mice. Horm Metab Res 32:181-184
29. Nilsson O, Falk J, Ritzen EM, Baron J, Savendahl L 2003 Raloxifene acts as an estrogen agonist on the rabbit growth plate. Endocrinology 144:1481-1485
30. Smith CL, O'Malley BW 2004 Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev 25:45-71
31. Quaedackers ME, Van Den Brink CE, Wissink S, Schreurs RH, Gustafsson Jk JA, Van Der Saag PT, Van Der Burg BB 2001 4-Hydroxytamoxifen transrepresses nuclear factor-κB activity in human osteoblastic U2-OS cells through estrogen receptor (ER)α, and not through ERβ. Endocrinology 142:1156-1166
32. Sibonga JD, Dobnig H, Harden RM, Turner RT 1998 Effect of the high-affinity estrogen receptor ligand ICI 182,780 on the rat tibia. Endocrinology 139:3736-3742
33. Tobias JH 1999 The effects of SERMs on the skeleton. J Endocrinol Invest 22:604-608
34. Fiore CE, Pennisi P, Tandurella FG, Amato R, Giuliano L, Amico A, Sciacchitano GS, Caschetto S 2001 Response of biochemical markers of bone turnover to estrogen treatment in post-menopausal women: evidence against an early anabolic effect on bone formation. J Endocrinol Invest 24:423-429
35. Vedi S, Purdie DW, Ballard P, Bord S, Cooper AC, Compston JE 1999 Bone remodeling and structure in postmenopausal women treated with long-term, high-dose estrogen therapy. Osteoporosis Int 28:52-58
36. Powles TJ, Hickish T, Kanis JA, Tidy A, Ashley S 1996 Effect of tamoxifen on bone mineral density measured by dual energy x-ray absorptiometry in healthy premenopausal and postmenopausal women. J Clin Oncol 14:78-84
37. Perry MJ, Samuels A, Bird D, Tobias J H 2000 The effects of high-dose estrogen on murine hematopoietic marrow precede those on osteogenesis. Am J Physiol 279:E1159-E1165
38. Manolagas SC, Kousteni S, Jilka RL 2002 Sex steroids and bone. Recent Prog Horm Res 57:385-409