A Longitudinal Study of the Effect of Subcutaneous Estrogen Replacement on Bone in Young Women With Turner's Syndrome

Journal of Bone and Mineral Research

Volumn 18, Issue 5, 2003, Pages 925-932

  Khastgir, Gautam ^a   Studd, John W W ^a   Fox, Simon W ^c   Jones, Julia ^b   Alaghband Zadeh, Jamshid ^b   Chow, Jade W M ^c  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b CHARING CROSS HOSPITAL   (United Kingdom)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Bone histomorphometry; Estrogen; Turner's syndrome

Indexed keywords

ESTROGEN; MEDROXYPROGESTERONE;

ADULT; ARTICLE; BONE DENSITY; BONE MARROW BIOPSY; BONE MASS; BONE MINERAL; BONE TURNOVER; CANCELLOUS BONE; CLINICAL ARTICLE; ESTROGEN THERAPY; FEMALE; HUMAN; HUMAN TISSUE; LONGITUDINAL STUDY; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; OVARY INSUFFICIENCY; TURNER SYNDROME;

ADULT; BONE DENSITY; BONE RESORPTION; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; LONGITUDINAL STUDIES; TURNER SYNDROME;

EID: 0142059599     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.5.925     Document Type: Article

References (32)

1. Smith MA, Wilson J, Price WH 1982 Bone demineralisation in patients with Turner's syndrome. J Med Genet 19:100-103.
2. Naeraa RW, Brixen K, Hansen RM, Hasling C, Mosekilde L, Andresen JH, Charles P, Nielsen J 1991 Skeletal size and bone mineral content in Turner's syndrome: Relation to karyotype, estrogen treatment, physical fitness and bone turnover. Calcif Tissue Int 49:77-83.
3. Shore RM, Chesney RW, Mazess RB, Rose PG, Bargman GJ 1982 Skeletal demineralization in Turner's syndrome. Calcif Tissue Int 34:519-522.
4. Beals RK 1973 Orthopedic aspects of the XO (Turner's) syndrome. Clin Orthop 97:19-30.
5. Davies MC, Hall ML, Jacobs HS 1990 Bone mineral loss in young women with amenorrhea. BMJ 301:790-793.
6. Davies MC, Gulekli B, Jacobs HS 1995 Osteoporosis in Turner's syndrome and other forms of primary amenorrhea. Clin Endocrinol (Oxf) 43:741-746.
7. Sylvén L, Hagenfeldt K, Ringertz H 1995 Bone mineral density in middle-aged women with Turner's syndrome. Eur J Endocrinol 132:47-52.
8. Ross J, Long L, Loriaux D, Cutler G 1985 Growth hormone secretory dynamics in Turner's syndrome. J Pediatr 106:202-206.
9. Neely EK, Marcus R, Rosenfeld RG, Bachrach LK 1993 Turner syndrome adolescents receiving growth hormone are not osteopenic. J Clin Endocrinol Metab 76:861-866.
10. Ernst M, Schmid C, Froesch ER 1988 Enhanced osteoblast proliferation and collagen gene expression by estradiol. Proc Natl Acad Sci USA 85:2307-2310.
11. Komm BS, Terpening CM, Benz DJ, Graeme KA, Gallegos A, Korc M, Greene GL, O'Malley BW, Haussler MR 1988 Estrogenic binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science 241:81-84.
12. Chow J, Tobias JH, Colston KW, Chambers TJ 1992 Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation. J Clin Invest 89:74-78.
13. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams T, Lubahn DB, Korach KS 1994 Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331:1056-1061.
14. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K 1995 Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80:3689-3698.
15. Vedi S, Purdie DW, Ballard P, Board S, Cooper AC, Compston JE 1999 Bone remodeling and structure in postmenopausal women treated with long-term, high-dose estrogen therapy. Osteoporos Int 10:52-58.
16. Khastgir G, Studd J, Holland N, Alaghband-Zadeh J, Fox S, Chow J 2001 Anabolic effect of estrogen replacement on bone in postmenopausal women with osteoporosis: Histomorphometric evidence in a longitudinal study. J Clin Endocrinol Metab 86:289-295.
17. Sato N, Nimura A, Horikawa R, Katumata N, Tanae A, Tanaka T 2000 Bone mineral density in Turner syndrome: Relation to GH treatment and estrogen treatment. Endocr J 47(Suppl):S115-S119.
18. Mora S, Weber G, Guarneri MP, Nizzoli G, Pasolini D, Chiumello G 1992 Effect of estrogen replacement therapy on bone mineral content in girls with Turner syndrome. Obstet Gynaecol 79:747-751.
19. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche HH, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: Standardization of nomenclature, symbols and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610.
20. Stepan JJ, Musilova J, Pacovsky V 1989 Bone demineralization, biochemical indices of bone remodeling, and estrogen replacement therapy in adults with Turner's syndrome. J Bone Miner Res 4:193-198.
21. Gravholt CH, Juul SRWN, Hansen J 1998 Morbidity in Turner syndrome. J Clin Epidemiol 51:147-158.
22. Takano-Yamamoto T, Rodan GA 1990 Direct effects of 17β-estradiol on trabecular bone in ovariectomised rats. Proc Natl Acad Sci USA 87:2172-2176.
23. Chow JWM, Lean JM, Chambers TJ 1992 17β-estradiol stimulates cancellous bone formation in female rats. Endocrinology 130:3025-3032.
24. Reginster JY, Sarlet N, Deroisy R, Albert A, Gaspard U, Franchimont P 1992 Minimal levels of serum estradiol prevent postmenopausal bone loss. Calcif Tissue Int 51:340-343.
25. Chiu KM, Ju J, Mayes D, Bacchetti P, Weitz S, Arnaud CD 1999 Changes in bone resorption during the menstrual cycle. J Bone Miner Res 14:609-915.
26. Brown DM, Jowsey J, Bradford DS 1974 Osteoporosis in ovarian dysgenesis. J Pediatr 84:816-820.
27. Tomkinson A, Gevers EF, Wit JM, Reeve J, Noble BS 1998 The role of estrogen in the control of rat osteocyte apoptosis. J Bone Miner Res 13:1243-1250.
28. Hannon R, Blumsohn A, Naylor K, Eastell R 1998 Response of biochemical markers of bone turnover to hormone replacement therapy: Impact of biological variability. J Bone Miner Res 13:1124-1133.
29. Tobias JH, Chambers TJ 1989 Bidirectional response of rat osteoclasts to 17β-estradiol. J Endocrinol 123(Suppl):97.
30. Shahtaheri SM, Aaron JE, Johnson DR, Paxton SK 1999 The impact of mammalian reproduction on cancellous bone architecture. J Anat 194:407-421.
31. Sims NA, Dupont S, Kinst A, Clement-Lacroix P, Minet D, Resche-Rigon M, Gaillard-Kelly M, Baron R 2002 Deletion of estrogen receptors reveals a regulatory role for estrogen receptor-β in bone remodelling in females but not in males. Bone 30:18-25.
32. Hall JM, McDonnell DP 1999 The estrogen receptor beta-isoform (ER beta) of the human estrogen receptor modules ER alpha transcriptional activity and is a key regulator of the cellular responses to estrogens and antiestrogens. Endocrinology 140:5566-5578.