Inhibition of human telomerase by oligonucleotide chimeras, composed of an antisense moiety and a chemically modified homo-oligonucleotide

FEBS Letters

Volumn 579, Issue 6, 2005, Pages 1411-1416

  Tarkanyi, Ilona ^a,b   Horváth, András ^a   Szatmari, Istvan ^a   Eizert, Helga ^a   Vámosi, György ^a   Damjanovich, Sándor ^a   Ségal Bendirdjian, Evelyne ^b   Aradi, Janos ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b SAINT LOUIS HOSPITAL   (France)

Author keywords

4 Thio deoxyuridylate; Antisense; Telomerase

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; OLIGONUCLEOTIDE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TELOMERASE; TELOMERASE INHIBITOR;

ARTICLE; CHEMICAL MODIFICATION; CHIMERA; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INTERNALIZATION; PRIORITY JOURNAL;

EID: 14244264997     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.01.041     Document Type: Article

References (21)

1. G.B. Morin The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats Cell 59 1989 521 529
2. C. Kelleher, M.T. Teixeira, K. Förstemann, and J. Lingner Telomerase: biochemical considerations for enzyme and substrate Trends Biochem. Sci. 27 2002 572 579
3. N.W. Kim, M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, P.L.C. Ho, G.M. Covielo, W.E. Wright, S.L. Weinrich, and J.W. Shay Specific association of human telomerase activity with immortal cells and cancer Science 266 1994 2011 2015
4. N. Weng Interplay between telomere length and telomerase in human leukocyte differentiation and aging J. Leukoc. Biol. 70 2001 861 867
5. S.A. Stewart, W.C. Hahn, B.F. O'Connor, E.N. Banner, A.S. Lundberg, P. Modha, H. Mizuno, M.W. Brooks, M. Fleming, D.B. Zimonjic, N.C. Popescu, and R.A. Weinberg Telomerase contributes to tumorigenesis by a telomere length-independent mechanism Proc. Natl. Acad. Sci. USA 99 2002 12606 12611
6. J.L. Mergny, J.F. Riou, P. Mailliet, M.P. Teulade-Fichou, and E. Gilson Natural and pharmacological regulation of telomerase Nucleic Acids Res. 30 2002 839 865
7. E. Matthes, and Ch. Lehmann Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides Nucleic Acids Res. 27 1999 1152 1158
8. A. Asai, Y. Oshima, Y. Yamamoto, T. Uochi, H. Kusaka, S. Akinaga, Y. Yamashita, K. Pongracz, R. Pruzan, E. Wunder, M. Piatyszek, S. Li, A.C. Chin, C.B. Harley, and S. Gryaznow A novel telomerase antagonist (GRN163) as a potential anticancer agent Cancer Res. 63 2003 3931 3939
9. M. Tao, N. Miyano-Kurosaki, K. Takai, and H. Takaku Specific inhibition of human telomerase activity by transfection agent, FuGENE6-antisense phosphorothioate oligonucleotide complex in HeLa cells FEBS Lett. 454 1999 312 316
10. J.C. Norton, M.A. Piatyszek, W.E. Wright, J.W. Shay, and D.R. Corey Inhibition of human telomerase activity by peptide nucleic acids Nat. Biotechnol. 14 1996 615 619
11. B.S. Herbert, A.E. Pitts, S.I. Baker, S.E. Hamilton, W.E. Wright, J.W. Shay, and D.R. Corey Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death Proc. Natl. Acad. Sci. USA 96 1999 14276 14281
12. A.E. Elayadi, A. Demieville, E.V. Wancewicz, B.P. Monia, and D.R. Corey Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells Nucleic Acids Res. 29 2001 1683 1689
13. I. Szatmári, Sz. Tokés, C.D. Dunn, T.J. Bardos, and J. Aradi Modified telomeric repeat amplification protocol: a quantitative radioactive assay for telomerase without using electrophoresis Anal. Biochem. 282 2000 80 88
14. Horvath A. and Aradi J. (2004) Advantage of sodium-perchlorate solution as mobile phase for purification of synthetic oligonucleotides by anion-exchange chromatography. Anal. Biochem. (in press)
15. 4dU): a novel, highly potent oligonucleotide inhibitor of the human immunodeficiency virus type1 reverse transcriptase FEBS Lett. 396 1996 43 46
16. G.T. Merlino, Y.H. Xu, S. Ishii, A.J. Clark, K. Semba, K. Toyoshima, T. Yamamoto, and I. Pastan Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells Science 224 1984 417 419
17. K. Miura, and T. Ueda Modification of cytosine moieties of nucleic acids with hydrogen sulfide (Nucleosides and Nucleotides. XXXIV) Chem. Pharm. Bull. 28 1980 3415 3418
18. T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner, C.B. Harley, and T.R. Cech Telomerase catalytic subunit homologs from fission yeast and human Science 277 1997 955 959
19. N.F. Lue, and Y. Peng Negative regulation of yeast telomerase activity through an interaction with an upstream region of the DNA-primer Nucleic Acids Res. 26 1998 1487 1494
20. F. Shi, and D. Hoekstra Effective intracellular delivery of oligonucleotides in order to make sense of antisense Rev. J. Control. Release 97 2004 189 209
21. S. Kyo, K. Masutomi, Y. Maida, T. Kanaya, N. Yatabe, M. Nakamura, M. Tanaka, M. Takadar, I. Sugawara, S. Murakami, T. Taira, and M. Inoue Significance of immunological detection of human telomerase reverse transcriptase Am. J. Pathol. 163 2003 859 867