Novel function of neuronal PAS domain protein 1 in erythropoietin expression in neuronal cells

Journal of Neuroscience Research

Volumn 79, Issue 4, 2005, Pages 451-458

  Ohsawa, Shizue ^a,b   Hamada, Shun ^b,c   Kakinuma, Yoshihiko ^d   Yagi, Takeshi ^b,c   Miura, Masayuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

bHLH PAS transcriptional factor; Cortical development; Erythropoietin; Hypoxia; NPAS1

Indexed keywords

ANTIBODY; ERYTHROPOIETIN; HELIX LOOP HELIX PROTEIN; LUCIFERASE; NEURONAL PAS DOMAIN PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; DEVELOPMENTAL STAGE; DNA RESPONSIVE ELEMENT; EMBRYO DEVELOPMENT; ENHANCER REGION; GENE EXPRESSION REGULATION; GESTATIONAL AGE; HUMAN; HUMAN CELL; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

ANIMALS; ANIMALS, NEWBORN; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; BRAIN; CELL HYPOXIA; CELL LINE; CHROMATIN; DEFEROXAMINE; DNA-BINDING PROTEINS; EMBRYO; ERYTHROPOIETIN; GENE EXPRESSION; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HELIX-LOOP-HELIX MOTIFS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IRON CHELATING AGENTS; MICE; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NEURONS; RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAINING AND LABELING; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 14144250097     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20365     Document Type: Article

References (30)

1. Bernaudin M, Bellail A, Marti HH, Yvon A, Vivien D, Duchatelle I, Mackenzie ET, Petit E. 2000. Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain. Glia 30:271-278.
2. Buemi M, Cavallaro E, Floccari F, Sturiale A, Aloisi C, Trimarchi M, Grasso G, Corica F, Frisina N. 2002. Erythropoietin and the brain: from neurodevelopment to neuroprotection. Clin Sci (Lond) 103:275-282.
3. Crews ST. 1998. Control of cell lineage-specific development and transcription by bHLH-PAS proteins. Genes Dev 12:607-620.
4. Dunlap JC. 1999. Molecular bases for circadian clocks. Cell 96:271-290.
5. Huang ZJ, Edery I, Rosbash M. 1993. PAS is a dimerization domain common to Drosophila period and several transcription factors. Nature 364:259-262.
6. Isaac DD, Andrew DJ. 1996. Tubulogenesis in Drosophila: a requirement for the trachealess gene product. Genes Dev 10:103-117.
7. Kikuchi Y, Ohsawa S, Mimura J, Ema M, Takasaki C, Sogawa K, Fujii-Kuriyama Y. 2003. Heterodimers of bHLH-PAS protein fragments derived from AhR, AhRR, and Arnt prepared by co-expression in Escherichia coli: characterization of their DNA binding activity and preparation of a DNA complex. J Biochem (Tokyo) 134:83-90.
8. Liu ZY, Chin K, Noguchi CT. 1994. Tissue specific expression of human erythropoietin receptor in transgenic mice. Dev Biol 166:159-169.
9. Matsushita N, Sogawa K, Ema M, Yoshida A, Fujii-Kuriyama Y. 1993. A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Amt. J Biol Chem 268:21002-21006.
10. Mimura J, Fujii-Kuriyama Y. 2003. Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 1619:263-268.
11. Nambu JR, Franks RG, Hu S, Crews ST. 1990. The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells. Cell 63:63-75.
12. Nambu JR, Lewis JO, Wharton KA Jr, Crews ST. 1991. The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development. Cell 67:1157-1167.
13. 2 homeostasis by hypoxia-inducible factor 1α. Genes Dev 12:149-162.
14. Numayama-Tsuruta K, Kobayashi A, Sogawa K, Fujii-Kuriyama Y. 1997. A point mutation responsible for defective function of the aryl-hydrocarbon- receptor nuclear translocator in mutant Hepa-1c1c7 cells. Eur J Biochem 246:486-495.
15. Ryan HE, Lo J, Johnson RS. 1998. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17:3005-3015.
16. 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15:551-578.
17. Shingo T, Sorokan ST, Shimazaki T, Weiss S. 2001. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci 21:9733-9743.
18. Sonnenfeld M, Ward M, Nystrom G, Mosher J, Stahl S, Crews S. 1997. The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Amt and controls CNS midline and tracheal development. Development 124:4583-4594.
19. Studer L, Csete M, Lee SH, Kabbani N, Walikonis J, Wold B, McKay R. 2000. Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J Neurosci 20:7377-7383.
20. Thomas JB, Crews ST, Goodman CS. 1988. The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. Cell 52:133-141.
21. Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama R, Ueda N, Gonzalez FJ, Takahama Y. 2003. Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol 23:6739-6749.
22. Wang GL, Jiang BH, Rue EA, Semenza GL. 1995. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92:5510-5514.
23. Wang GL, Semenza GL. 1993a. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 268:21513-21518.
24. Wang GL, Semenza GL. 1993b. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 90:4304-4308.
25. Wigglesworth VB. 1954. Growth and regeneration in the tracheal system of an insect, Rhodnius prolixus (Hemiptera). Q J Microsc Sci 95:115-137.
26. Wilk R, Weizman I, Shilo BZ. 1996. trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila. Genes Dev 10:93-102.
27. Youssoufian H, Longmore G, Neumann D, Yoshimura A, Lodish HF. 1993. Structure, function, and activation of the erythropoietin receptor. Blood 81:2223-2236.
28. Yu X, Shacka JJ, Eells JB, Suarez-Quian C, Przygodzki RM, Beleslin-Cokic B, Lin CS, Nikodem VM, Hempstead B, Flanders KC, Costantini F, Noguchi CT. 2002. Erythropoietin receptor signalling is required for normal brain development. Development 129:505-516.
29. Zelzer E, Wappner P, Shilo BZ. 1997. The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins. Genes Dev 11:2079-2089.
30. Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL. 1997. Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci USA 94:713-718.