FFAs: Do they play a role in vascular disease in the insulin resistance syndrome?

Current Diabetes Reports

Volumn 5, Issue 1, 2005, Pages 30-35

  Shankar, Sudha S ^b   Steinberg, Helmut O ^a  

^a INDIANA UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; C REACTIVE PROTEIN; CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FATTY ACID; GLYCERYL TRINITRATE; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; ISOENZYME; METHACHOLINE CHLORIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

BODY WEIGHT DISORDER; CARDIOVASCULAR DISEASE; DISEASE ASSOCIATION; ENDOTHELIUM; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SYNTHESIS; FATTY ACID BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; METABOLIC DISORDER; METABOLIC SYNDROME X; MORBIDITY; MORTALITY; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR DISEASE; VASODILATATION;

EID: 14044268798     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-005-0064-6     Document Type: Review

References (37)

1. Reaven GM: Role of insulin resistance in human disease. Diabetes 1988, 37:1595-1607.
2. Fontbonne A, Charles MA, Thibult N, et al.: Hyperinsulinaemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up. Diabetologia 1991, 34:356-361.
3. Fontbonne A, Eschwege E: Insulin-resistance, hypertriglyceridaemia and cardiovascular risk: the Paris Prospective Study. Diabetes Metab 1991, 17(1 Pt 2):93-95.
4. Nilsson P, Nilsson JA, Hedblad B, et al.: Hyperinsulinaemia as long-term predictor of death and ischaemic heart disease in nondiabetic men: the Malmo Preventive Project. J Intern Med 2003, 253:136-145.
5. Lempiainen P, Mykkanen L, Pyorala K, et al.: Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. Circulation 1999, 100:123-128.
6. Hedblad B, Nilsson P, Engstrom G, et al.: Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death. Diabet Med 2002, 19:470-475.
7. Steinberg HO, Chaker H, Leaming R, et al.: Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 1996, 97:2601-2610.
8. Reaven GM: Syndrome X: 6 years later. J Intern Med 1994, 236(suppl 736):13-22.
9. Boden, G, Chen X, Ruiz J, et al.: Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 1994, 93:2438-2446.
10. Dresner A, Laurent D, Marcucci M, et al.: Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 1999, 103:253-259.
11. Boden G, Lebed B, Schatz M, et al.: Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 2001, 50: 612-1617.
12. Steinberg HO, Tarshoby M, Monestel R, et al.: Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 1997, 100:1230-1239.
13. Steinberg HO, Baron AD: Vascular function, insulin resistance and fatty acids. Diabetologia 2002, 45:623-634.
14. de Kreutzenberg SV, Crepaldi C, Marchetto S, et al.: Plasma free fatty acids and endothelium dependent-vasodilation: effect of chain-length and cyclooxygenase inhibition. J Clin Endocrinol Metab 2000, 85:793-798.
15. Lundman P, Eriksson M, Schenck-Gustafsson K, et al.: Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease. Circulation 1997, 96:3266-3268.
16. de Jongh RT, Serne EH, Ijzerman RG, et al.: Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy Diabetes 2004, 53:2873-2882.
17. Fugmann A, Millgard J, Sarabi M, et al.: Central and peripheral haemodynamic effects of hyperglycaemia, hyperinsulinaemia, hyperlipidaemia or a mixed meal. Clin Sci (Lond) 2003, 105: 15-721.
18. Sarabi M, Vessby B, Millgard J, Lind L: Endothelium-dependent vasodilation is related to the fatty acid composition of serum lipids in healthy subjects. Atherosclerosis 2001, 156:349-355.
19. Davda RK, Stepniakowski KT, Lu G, et al.: Oleic acid inhibits endothelial nitric oxide synthase by a protein kinase C-independent mechanism. Hypertension 1995, 26:764-770.
20. Kuroda R, Hirata K, Kawashima S, Yokoyama M: Unsaturated free fatty acids inhibit Ca2+ mobilization and NO release in endothelial cells. Kobe J Med Sci 2001, 47:211-219.
21. Verma S, Wang CH, Li SH, et al.: A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation 2002, 106:913-919.
22. Stuhlinger MC, Abbasi F, Chu JW, et al.: Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. JAMA 2002, 287:1420-1426.
23. Tripathy D, Mohanty P, Dhindsa S, et al.: Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes 2003, 52:2882-2887.
24. Ghanim H, Aljada A, Hofmeyer D, et al.: Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 2004, 110:1564-1571.
25. Bluher M, Unger R, Rassoul F, et al.: Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or type II diabetes. Diabetologia 2002, 45:210-216.
26. Toborek M, Lee YW, Garrido R, et al.: Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells. Am J Clin Nutr 2002, 75:119-125.
27. Steinberg HO, Paradisi G, Hook G, et al.: Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production. Diabetes 2000, 49:1231-1238.
28. Baron AD: Hemodynamic actions of insulin. Am J Physiol 1994, 267:E187-E202.
29. Steinberg HO, Brechtel G, Johnson A, et al.: Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent J Clin Invest 1994, 94:1172-1179.
30. Scherrer U, Randin D, Vollenweider P, et al.: Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 1994, 94:2511-2515.
31. Laakso M, Edelman SV, Brechtel G, Baron AD: Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 1992, 41:1076-1083.
32. Coggins M, Lindner J, Rattigan S, et al.: Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. Diabetes 2001, 50:2682-2690.
33. Vincent MA, Barrett EJ, Lindner JR, et al.: Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin. Am J Physiol Endocrinol Metab 2003, 285:E123-E129.
34. Hedman A, Andersson PE, Reneland R, Lithell HO: Insulin-mediated changes in leg blood flow are coupled to capillary density in skeletal muscle in healthy 70-year-old men. Metabolism 2001, 50:1078-1082.
35. Clerk LH, Rattigan S, Clark MG: Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo. Diabetes 2002, 51:1138-1145.
36. Zeng G, Nystrom FH, Ravichandran LV, et al.: Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells Circulation 2000, 101:1539-1545.
37. Lynn MA, Rupnow HL, Kleinhenz DJ, et al.: Fatty acids differentially modulate insulin-stimulated endothelial nitric oxide production by an Akt-independent pathway. J Investig Med 2004, 52:129-136.