Unsaturated free fatty acids inhibit Ca2+ mobilization and NO release in endothelial cells

Kobe Journal of Medical Sciences

Volumn 47, Issue 5, 2001, Pages 211-219

  Kuroda, Ryohei ^a   Hirata, Ken Ichi ^a   Kawashima, Seinosuke ^a   Yokoyama, Mitsuhiro ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Endothelial cell; Free fatty acid; Intracellular calcium; Nitric oxide

Indexed keywords

ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ALBUMINOID; CALCIUM ION; LINOLEIC ACID; NITRIC OXIDE; OLEIC ACID; PALMITIC ACID; PHOSPHATIDYLINOSITIDE; UNSATURATED FATTY ACID;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL CULTURE; CELL DAMAGE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; ENDOTHELIUM CELL; EXTRACELLULAR SPACE; HYDROLYSIS; INSULIN RESISTANCE; NONHUMAN;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FATTY ACIDS, UNSATURATED; NITRIC OXIDE;

EID: 0035732781     PISSN: 00232513     EISSN: 18830498     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Inositol triphosphate, a novel second messenger in cellular signal transduction
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. Associations between insulin sensitivity, and free fatty acid and triglyceride metabolism independent of uncomplicated obesity
4. Oleic acid inhibits endothelial nitric oxide synthase by a protein kinase C-independent mechanism
5. Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease
6. 2+ indicators with greatly improved fluorescence properties
7. Oxidized low density lipoprotein inhibits bradykinin-induced phosphoinositide hydrolysis in cultured bovine aortic endothelial cells
8. Inhibition of endothelial nitric oxide synthase activity by protein kinase C
9. Lysophosphatidylcholine inhibits bradykinin-induced phosphoinositide hydrolysis and calcium transients in cultured bovine aortic endothelial cells
10. Lysophosphatidylcholine inhibits surface receptor mediated intracellular signals in endothelial cells by a pathway involving protein kinase C activation
11. Nitric oxide: Physiology, pathophysiology, and pharmacology
12. The role of protein kinase C in cell surface signal transduction and tumor promotion
13. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells
14. Elevated circulating free fatty acid level impair endothelium-dependent vasodilation