Phase I/II study of selective cyclooxygenase-2 inhibitor celecoxib as a radiation sensitizer in patients with unresectable brain metastases

Journal of Neuro-Oncology

Volumn 71, Issue 1, 2005, Pages 73-81

  Cerchietti, Leandro C A ^a,b   Bonomi, Marcelo R ^a   Navigante, Alfredo H ^a   Castro, Monica A ^a   Cabalar, Maria E ^a   Roth, Berta M C ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b ALBERT EINSTEIN CANCER CENTER   (United States)

Author keywords

Brain metastases; Celecoxib; Cyclooxygenase; Radiation; Radiosensitizer

Indexed keywords

CELECOXIB; COBALT 60; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; DIPHENHYDRAMINE; GABAPENTIN; METOCLOPRAMIDE; RADIOSENSITIZING AGENT; RANITIDINE; VALPROIC ACID;

ADULT; AGED; ALOPECIA; ARTICLE; BRAIN METASTASIS; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COBALT THERAPY; COMPUTER ASSISTED TOMOGRAPHY; CONVULSION; CUSHINGOID SYNDROME; DESQUAMATION; DISEASE COURSE; DOSE RESPONSE; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; DRUG SELECTIVITY; DRUG TOLERABILITY; DYSPEPSIA; EDEMA; FATIGUE; FEASIBILITY STUDY; FEMALE; HUMAN; HYPERGLYCEMIA; HYPERTENSION; INDEPENDENCE; INSOMNIA; INTELLECTUAL IMPAIRMENT; MALE; MEDICAL ASSESSMENT; MUSCLE WEAKNESS; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; RADIATION DOSE FRACTIONATION; RASH; SAFETY; TIME; TREATMENT OUTCOME;

ADULT; AGED; BRAIN NEOPLASMS; BREAST NEOPLASMS; COMBINED MODALITY THERAPY; CYCLOOXYGENASE INHIBITORS; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG NEOPLASMS; MALE; MELANOMA; MIDDLE AGED; PYRAZOLES; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY DOSAGE; SULFONAMIDES; TREATMENT OUTCOME;

EID: 14044267005     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11060-004-9179-x     Document Type: Article

References (54)

1. AE Walker M Robins FD Weinfeld 1985 Epidemiology of brain tumors: The national survey of intracranial neoplasms Neurology 35 219-224 1:STN:280:BiqC3M7lsVE%3D 3969210
2. L Gaspar C Scott M Rotman S Asbell T Phillips T Wasserman WG McKenna R Byhardt 1997 Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials Int J Radiat Oncol Biol Phys 37 745-751
3. LE Gaspar C Scott KJ Murray W Curran 2000 Validation of the RTOG recursive partitioning analysis classification for brain metastases Int J Radiat Oncol Biol Phys 47 1001-1006
4. O Agboola B Benoit C Cross V Da Silva B Esche H Lesiuk C Gonsalves 1998 Prognostic factors derived from recursive partition analysis (RPA) of Radiation Therapy Oncology Group (RTOG) brain metastases trials applied to surgically resected and irradiated brain metastatic cases Int J Radiation Oncol Biol Phys 42 155-159
5. C Nieder U Nestle B Motaref K Walter M Niewald K Schnabel 2000 Prognostic factors in brain metastases: Should patients be selected for aggressive treatment according to recursive partitioning analysis (RPA) classes Int J Radiation Oncol Biol Phys 46 297-302
6. GA FitzGerald C Patrono 2001 The coxibs, selective inhibitors of cyclooxygenase-2 N Engl J Med 345 433-442 10.1056/NEJM200108093450607 1:STN:280:DC%2BD3MvltVyltQ%3D%3D 11496855
7. H Raju E Nakata P Yang RA Newman KK Ang L Milas 2002 In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: Mechanistics considerations Int J Radiation Oncology Biol Phys 54 886-894
8. H Pyo H Choy GP Amorino JS Kim Q Cao SK Hercules RN DuBois 2001 A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2 Clin Cancer Res 7 2998-3005
9. L Milas K Kishi N Hunter K Mason JL Masferrer PJ Tofilon 1999 Enhancement of tumor response to -radiation by an inhibitor of cyclooxygenase-2 enzyme J Natl Cancer Inst 91 1501-1504
10. ChJ Vecht A Hovestadt HB Verbiest JJ Vliet van WL Putten van 1994 Dose-effect relationship of dexamethasone on Karnofsky performance in metastatic brain tumors: A randomized study of doses of 4, 8, and 16 mg per day Neurology 44 675-680
11. N Cohen G Strauss R Lew D Silver L Recht 1988 Should prophylactic anticonvulsants be administered to patients with newly-diagnosed cerebral metastases? A retrospective analysis. J Clin Onco 16 1621-1624
12. C Tang M Shou Q Mei TH Rushmore AD Rodrigues 2000 Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-ll inhibitor J Pharmacol Exp Ther 293 453-459
13. MM Oken RH Creech DC Tormey J Horton TE Davis ET McFadden PP Carbone 1982 Toxicity and response criteria of the Eastern Cooperative Oncology Group Am J Clin Oncol 5 649-655 1:STN:280:BiyC2cbntlU%3D 7165009
14. MK Jones H Wang BM Peskar E Levin RM Itani IJ Sarfeh AS Tarnawski 1999 Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing Nat Med 5 1418-1423 10.1038/70995 1:CAS:528:DyaK1MXnvFGju7g%3D 10581086
15. K Kishi S Petersen C Petersen N Hunter K Mason JL Masferrer PJ Tofilon L Milas 2000 Preferential enhancement of tumor radioresponse by a cyclooxygenase-2 inhibitor Cancer Res 60 1326-1331
16. CS Williams M Mann RN DuBois 1999 The role of cyclooxygenases in inflammation, cancer, and development Oncogene 18 7908-7916
17. HS Ryu KH Chang HW Yang MS Kim HC Kwom KS Oh 2000 High cyclooxygenase-2 expression in stage IB cervical cancer with lymph node metastasis or parametrial invasion Gynecol Oncol 76 320-325
18. AS Michalowski 1994 On radiation damage to normal tissues and its treatment II. Anti-inflammatory drugs. Acta Oncol 33 139-157
19. L Milas Y Furuta N Hunter I Nishiguchi S Runkel 1990 Dependence of indomethacin-induced potentiation of murine tumor radioresponse on tumor host immunocompetence Cancer Res 50 4473-4477
20. Y Furuta N Hunter T Barkley E Hall L Milas 1988 Increase in radioresponse of murine tumors by treatment with indomethacin Cancer Res 48 3008-3013
21. JL Masferrer KM Leahy AT Koki BS Zweifel SL Settle BM Woerner DA Edwards AG Flickinger RJ Moore K Seibert 2000 Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors Cancer Res 60 1306-1311 1:CAS:528:DC%2BD3cXhvFWrt74%3D 10728691
22. AP Dicker TL Williams DS Grant 2001 Targeting angiogenic processes by combination rofecoxib and ionizing radiation Am J Clin Oncol 24 438-442
23. RA Soslow AJ Dannenberg D Rush BM Woerner KN Khan J Masferrer AT Koki 2000 COX-2 is expressed in human pulmonary, colonic, and mammary tumors Cancer 89 2637-2645 1:CAS:528:DC%2BD3MXitFWisw%3D%3D 11135226
24. H Wolff K Saukkonen S Anttila A Karjalainen H Vainio A Ristimaki 1998 Expression of cyclooxygenase-2 in human lung carcinoma Cancer Res 58 4997-5001
25. D Hwang D Scollard J Byrne E Levine 1998 Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer J Natl Cancer Inst 90 455-460
26. C Denkert M Kobel S Berger A Siegert A Leclere U Trefzer S Hauptmann 2001 Expression of cyclooxygenase 2 in human malignant melanoma Cancer Res 61 303-308
27. HJ Kim HG Wu IA Park SW Ha 2003 High cyclooxygenase-2 expression is related with distant metastasis in cervical cancer treated with radiotherapy Int J Radiat Oncol Biol Phys 55 16-20
28. L Milas R Komaki T Hachiya RS Bubb JY Ro L Langford R Sawaya JB Putnam P Alien JD Cox TJ McDonnell W Brock WK Hong JA Roth L Milas 2003 Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases Clinical Cancer Res 1 1070-1076
29. MA Hull SW Fenwick KS Chappie N Scott GJ Toogood JP Lodge 2001 Cyclooxygenase-2 expression in colorectal cancer liver metastases Clin Exp Metastasis 18 21-27
30. KK Steinauer I Gibbs S Ning JN French J Armstrong SJ Knox 2000 Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells Int J Rad Oncol Biol Phys 48 325-328
31. L Milas WR Hanson 1995 Eicosanoids and radiation Eur J Cancer 31 A 1580-1585
32. C Petersen S Petersen L Milas FF Lang PJ Tofilon 2000 Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor Clin Cancer Res 6 2513-2520
33. CS Williams AJ Watson H Sheng R Helou J Shao RN DuBois 2001 Celecoxib prevents tumor growth in vivo without toxicity to normal gut: Lack of correlation between in vitro and in vivo models Cancer Res 60 6045-6051
34. P Wachsberger R Burd AP Dicker 2003 Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: Exploring mechanisms of interaction Clin Cancer Res 9 1957-1971
35. R Burd H Choy A Dicker 2003 Potential for inhibitors of cyclooxygenase-2 to enhance tumor radioresponse In: RE Harris (ed) COX-2 Blockade in Cancer Prevention and Therapy Humana Press Inc Totowa, New Jersey 301-311
36. RD Blumenthal C Waskewich DM Goldenberg W Lew C Flefleh J Burton 2001 Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts Clin Cancer Res 7 3178-3185
37. E Stormer S Bauer J Kirchheiner J Brockmoller I Roots 2003 Simultaneous determination of celecoxib, hydrocelecoxib, and carboxycelecoxib in human plasma using gradient reversed-phase liquid chromatography with ultraviolet absorbance detection J Chromatogr B Analyt Technol Biomed Life Sci 783 207-212
38. P Davey 2002 Brain Metastases: Treatment options to improve outcomes CNS Drugs 16 325-338 1:CAS:528:DC%2BD38Xks1Omtrw%3D 11994022
39. KJ Murray C Scott HM Greenberg B Emami M Seider NL Vora C Olson A Whitton B Movsas W Curran 1997 A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases: A report of the radiation therapy oncology group (RTOG) 9104 Int J Radial Oncol Biol Phys 39 571-574
40. BB Ma RG Bristow J Kim LL Siu 2003 Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents J Clin Oncol 21 2760-2776
41. JA Bonner KP Raisch HQ Trummell F Robert RF Meredith SA Spencer DJ Buchsbaum MN Saleh MA Stackhouse AF LoBuglio GE Peters WR Carroll HW Waksal 2000 Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck J Clin Oncol 18 1 47-53
42. C Bianco R Bianco G Tortora V Damiano P Guerrieri P montemaggi J Mendelsohn S Placido De AR Bianco F Ciardiello 2000 Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide Clin Cancer Res 6 4343-4350
43. L Milas K Mason N Hunter S Petersen M Yamakawa K Ang J Mendelsohn Z Fan 2000 In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody Clin Cancer Res 6 701-708
44. JA Bonner J Maihle BR Folven TJ Christianson K Spain 1994 The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities Int J Radiat Oncol Biol Phys 29 243-247
45. HD Thames HR Withers LJ Peters GH Fletcher 1982 Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships Int J Radiat Oncol Biol Phys 8 219-222
46. MR Mehrabi N Serbecic F Tamaddon C Kaun K Huber R Pacher T Wild G Mall J Wojta HD Glogar 2002 Clinical and experimental evidence of prostaglandin E1-induced angiogenesis in the myocardium of patients with ischemic heart disease Cardiovasc Res 56 214-224
47. BM Fenton BK Beauchamp SF Paoni P Okunieff I Ding 2001 Characterization of the effects of antiangiogenic agents on tumor pathophysiology Am J Clin Oncol 24 453-457
48. C Nieder N Andratschke AL Grosu M Molls 2003 Recursive partitioning analysis (RFA) class does not predict survival in patients with four or more brain metastases Strahlenther Onkol 1 16-20
49. D Kondziolka A Patel LD Lunsford A Kassam JC Flickinger 1999 Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases Int J Rad Oncol Biol Phys 45 427-434
50. PH Gutin 1977 Corticosteroid therapy in patients with brain tumors Natl Cancer Inst Monogr 28 8-14
51. DE Weissman D Dufer V Vogel MD Abeloff 1987 Corticosteroid toxicity in neuro-oncology patients J Neuroncol 5 125-128
52. LF Marshall JK King TW Langfitt 1977 The complications of high-dose Corticosteroid therapy in neurosurgical patients: A prospective study Ann Neurol 1 201-203
53. S Kyrkanides AH Moore JA Olschowka JC Daeschner JP Williams JT Hansen M Kerry O'Banion 2002 Cyclooxygenase-2 modulates barin inflammation-related gene expression in central nervous System radiation injury Mol Brain Res 104 159-169
54. J Portnow S Suleman SA Grossman S Eller K Carson 2002 A cyclooxygenase-2 (COX-2) inhibitor compared with dexamethasone in a survival study of rats with intracerebral 9L gliosarcomas Neuro-oncol 4 22-25