메뉴 건너뛰기




Volumn 11, Issue 2, 2005, Pages 121-128

Is a long-acting inhaled bronchodilator the first agent to use in stable chronic obstructive pulmonary disease?

Author keywords

COPD; Inhaled corticosteroids; Long acting 2 agonist; Theophylline; Tiotropium

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; FORMOTEROL; IPRATROPIUM BROMIDE; SALBUTAMOL; SALMETEROL; THEOPHYLLINE; TIOTROPIUM BROMIDE;

EID: 14044265066     PISSN: 10705287     EISSN: None     Source Type: Journal    
DOI: 10.1097/00063198-200503000-00004     Document Type: Review
Times cited : (39)

References (91)
  • 1
    • 0003736031 scopus 로고    scopus 로고
    • National Heart Lung and Blood Institute/World Health Organization
    • Global Initiative for Chronic Obstructive Lung Disease: Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. National Heart Lung and Blood Institute/World Health Organization; 2003. Available at: http://www.goldcopd.com/revised.pdf. Accessed November 14, 2003. This authoritative report summarizes the current state of knowledge in COPD, including a section on the clinical management of COPD and recommendations for therapy based on different levels of evidence. Periodic updates will be available on the Internet.
    • (2003) Global Initiative for Chronic Obstructive Lung Disease: Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
  • 2
    • 1842552109 scopus 로고    scopus 로고
    • Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper
    • Celli BR, MacNee W, ATS/ERS Task Force: Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23:932-946. This document is the most recent update of the position papers on COPD published in 1995 by the American Thoracic Society and the European Respiratory Society. The American Thoracic Society/European Respiratory Society guidelines usefully complement the Global Initiative for Chronic Obstructive Lung Disease report with more specific recommendations concerning oxygen therapy, pulmonary rehabilitation, noninvasive ventilation, surgical therapies, sleep, air travel, and endof-life issues.
    • (2004) Eur Respir J , vol.23 , pp. 932-946
    • Celli, B.R.1    MacNee, W.2
  • 3
    • 1542405163 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease
    • National Institute for Clinical Excellence: Chronic obstructive pulmonary disease. Thorax 2004; 59:1-232. This is a comprehensive national clinical guideline developed by the National Institute for Clinical Excellence in the United Kingdom. It is the first set of guidelines to collate and examine systematically all the evidence in the published literature concerning the diagnosis and care of COPD.
    • (2004) Thorax , vol.59 , pp. 1-232
  • 4
    • 2542603339 scopus 로고    scopus 로고
    • Effect of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    • O'Donnell DE, Fluge T, Gerken F, et al. Effect of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 2004; 23:832-840. This randomized, double-blind, placebo-controlled clinical trial is the first to demonstrate progressive and significant increases in exercise endurance and reductions in perceived breathlessness during exercise during a 6-week course of treatment with tiotropium compared with placebo. These results were paralleled by sustained reductions in hyperinflation both at rest and during exercise, thereby providing a plausible explanation for the improvements in exercise tolerance and exertional dyspnea as a result of increases in inspiratory capacity that allowed greater expansion of the tidal volume during the hyperpnea of exercise.
    • (2004) Eur Respir J , vol.23 , pp. 832-840
    • O'Donnell, D.E.1    Fluge, T.2    Gerken, F.3
  • 5
    • 0030012048 scopus 로고
    • Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with COPD
    • Belman MJ, Botnick WC, Shin JW: Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with COPD. Am J Respir Crit Care Med 1990; 153:967-975.
    • (1990) Am J Respir Crit Care Med , vol.153 , pp. 967-975
    • Belman, M.J.1    Botnick, W.C.2    Shin, J.W.3
  • 6
    • 0037879081 scopus 로고    scopus 로고
    • Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses
    • Tashkin D, Kesten S: Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses. Chest 2003; 123:1441-1449.
    • (2003) Chest , vol.123 , pp. 1441-1449
    • Tashkin, D.1    Kesten, S.2
  • 7
    • 2942718553 scopus 로고    scopus 로고
    • FEV1 reversibility does not adequately predict effect of formoterol Aerolizer in chronic obstructive pulmonary disease
    • Muir JF, Benhamou D, Cuvelier A, et al. FEV1 reversibility does not adequately predict effect of formoterol Aerolizer in chronic obstructive pulmonary disease. Int J Clin Pract 2004; 58:457-464.
    • (2004) Int J Clin Pract , vol.58 , pp. 457-464
    • Muir, J.F.1    Benhamou, D.2    Cuvelier, A.3
  • 8
    • 0036913347 scopus 로고    scopus 로고
    • The effect of inhaled beta2-agonists on clinical outcomes in chronic obstructive pulmonary disease
    • Mahler D: The effect of inhaled beta2-agonists on clinical outcomes in chronic obstructive pulmonary disease. J Allergy Clin Immunol 2002; 110:S298-S303.
    • (2002) J Allergy Clin Immunol , vol.110
    • Mahler, D.1
  • 10
    • 0028341327 scopus 로고
    • Comparison of patients' compliance with prescribed oral and inhaled asthma medications
    • Kelloway JS, Wyatt RA, Adlis SA: Comparison of patients' compliance with prescribed oral and inhaled asthma medications. Arch Intern Med 1994; 154:1349-1352.
    • (1994) Arch Intern Med , vol.154 , pp. 1349-1352
    • Kelloway, J.S.1    Wyatt, R.A.2    Adlis, S.A.3
  • 11
    • 0026350725 scopus 로고
    • Anticholinergic bronchodilators for adult obstructive airways disease
    • Chapman K: Anticholinergic bronchodilators for adult obstructive airways disease. Am J Med 1991; 91:13S-16S.
    • (1991) Am J Med , vol.91
    • Chapman, K.1
  • 12
    • 0027462536 scopus 로고
    • Management of chronic obstructive pulmonary disease
    • Ferguson GT, Cherniack RM: Management of chronic obstructive pulmonary disease. N Engl J Med 1993; 328:1017-1022.
    • (1993) N Engl J Med , vol.328 , pp. 1017-1022
    • Ferguson, G.T.1    Cherniack, R.M.2
  • 13
    • 0028827084 scopus 로고
    • Statement ATS: Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease
    • Statement ATS: Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995; 152:S78-S121.
    • (1995) Am J Respir Crit Care Med , vol.152
  • 14
    • 0029156848 scopus 로고
    • ERS consensus statement: Optimal assessment and management of chronic obstructive pulmonary disease
    • Siafakas NM, Vermeire P, Pride NB, et al. ERS consensus statement: optimal assessment and management of chronic obstructive pulmonary disease. Eur Respir J 1995; 8:1398-1420.
    • (1995) Eur Respir J , vol.8 , pp. 1398-1420
    • Siafakas, N.M.1    Vermeire, P.2    Pride, N.B.3
  • 15
    • 14044275884 scopus 로고    scopus 로고
    • The COPD Guidelines Group of the Standards of Care Committee of the BTS. BTS guidelines for the 16.
    • BTS Guidelines for the 16
  • 16
    • 0028318612 scopus 로고
    • In chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone: An 85-day multicenter trial
    • COMBIVENT Inhalation Aerosol Study Group: In chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone: an 85-day multicenter trial. Chest 1994; 105:1411-1419.
    • (1994) Chest , vol.105 , pp. 1411-1419
  • 17
    • 0033022767 scopus 로고    scopus 로고
    • Pharmacoeconomic evaluation of a combination of ipratropium plus albuterol compared with ipratropium alone and albuterol alone in COPD
    • Friedman M, Serby CW, Menjoge SS, et al. Pharmacoeconomic evaluation of a combination of ipratropium plus albuterol compared with ipratropium alone and albuterol alone in COPD. Chest 1999; 115:635-641.
    • (1999) Chest , vol.115 , pp. 635-641
    • Friedman, M.1    Serby, C.W.2    Menjoge, S.S.3
  • 18
    • 0032909636 scopus 로고    scopus 로고
    • Efficacy of salmeterol xinafoate in the treatment of COPD
    • Mahler DA, Donohue JF, Barbee RA, et al. Efficacy of salmeterol xinafoate in the treatment of COPD. Chest 1999; 115:957-965.
    • (1999) Chest , vol.115 , pp. 957-965
    • Mahler, D.A.1    Donohue, J.F.2    Barbee, R.A.3
  • 19
    • 0035040553 scopus 로고    scopus 로고
    • 2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease
    • 2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 163:1087-1092.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1087-1092
    • Rennard, S.I.1    Anderson, W.2    ZuWallack, R.3
  • 20
    • 0035446985 scopus 로고    scopus 로고
    • Inhaled formoterol dry powder versus ipratropium bromide in chronic obstructive pulmonary disease
    • Dahl R, Greefhorst LAPM, Nowak D, et al. Inhaled formoterol dry powder versus ipratropium bromide in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164:778-784.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 778-784
    • Dahl, R.1    Greefhorst, L.A.P.M.2    Nowak, D.3
  • 21
    • 0036849465 scopus 로고    scopus 로고
    • Effects of formoterol and ipratropium bromide in COPD: A 3-month placebo-controlled trial
    • Wadbo M, Lofdahy C-G, Larsson K, et al. Effects of formoterol and ipratropium bromide in COPD: a 3-month placebo-controlled trial. Eur Respir J 2002; 20:1138-1146.
    • (2002) Eur Respir J , vol.20 , pp. 1138-1146
    • Wadbo, M.1    Lofdahy, C.-G.2    Larsson, K.3
  • 22
    • 13144250289 scopus 로고    scopus 로고
    • Health-related quality of life, symptoms, exercise capacity and lung function during treatment for moderate to severe COPD
    • Stahl E, Wadbo M, Bentsson T, et al. Health-related quality of life, symptoms, exercise capacity and lung function during treatment for moderate to severe COPD. J Drug Assess 2002; 5:81-94.
    • (2002) J Drug Assess , vol.5 , pp. 81-94
    • Stahl, E.1    Wadbo, M.2    Bentsson, T.3
  • 23
    • 18244368740 scopus 로고    scopus 로고
    • Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium
    • Vincken W, van Noord JA, Greefhorst APM, et al. Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium. Eur Respir J 2002; 19:209-216.
    • (2002) Eur Respir J , vol.19 , pp. 209-216
    • Vincken, W.1    Van Noord, J.A.2    Greefhorst, A.P.M.3
  • 24
    • 0034055236 scopus 로고    scopus 로고
    • A randomized controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease
    • van Noord JA, Bantje TA, Eland ME, et al. A randomized controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease. Thorax 2000; 55:289-294.
    • (2000) Thorax , vol.55 , pp. 289-294
    • Van Noord, J.A.1    Bantje, T.A.2    Eland, M.E.3
  • 25
    • 13144264117 scopus 로고    scopus 로고
    • Long acting beta-2 agonists for stable chronic obstructive pulmonary disease with poor reversibility: A systematic review of randomized controlled clinical trials
    • Husereau DR, Shukla VK, Boucher M, et al. Long acting beta-2 agonists for stable chronic obstructive pulmonary disease with poor reversibility: a systematic review of randomized controlled clinical trials. BMC Pulm Med 2004; 4:7. http://www.Biomedcentral.com/info/authors/.
    • (2004) BMC Pulm Med , vol.4 , pp. 7
    • Husereau, D.R.1    Shukla, V.K.2    Boucher, M.3
  • 26
    • 4644353712 scopus 로고    scopus 로고
    • Tiotropium bromide: A review of its use as maintenance therapy in patients with COPD
    • Keam SJ, Keating GM: Tiotropium bromide: a review of its use as maintenance therapy in patients with COPD. Treat Respir Med 2004; 3:247-268.
    • (2004) Treat Respir Med , vol.3 , pp. 247-268
    • Keam, S.J.1    Keating, G.M.2
  • 27
    • 0037795611 scopus 로고    scopus 로고
    • Long-acting beta2-agonists for chronic obstructive pulmonary disease patients with poorly reversible airflow limitation
    • Appleton S, Poole P, Smith B, et al. Long-acting beta2-agonists for chronic obstructive pulmonary disease patients with poorly reversible airflow limitation. Cochrane Database Syst Rev 2002; 3:CD001104.
    • (2002) Cochrane Database Syst Rev , vol.3
    • Appleton, S.1    Poole, P.2    Smith, B.3
  • 28
    • 0242577949 scopus 로고    scopus 로고
    • Contemporary management of chronic obstructive pulmonary disease
    • Sin DD, McAlister FA, Paul Man SF, et al. Contemporary management of chronic obstructive pulmonary disease. JAMA 2003; 290:2301-2312.
    • (2003) JAMA , vol.290 , pp. 2301-2312
    • Sin, D.D.1    McAlister, F.A.2    Paul Man, S.F.3
  • 29
    • 14044279452 scopus 로고    scopus 로고
    • note
    • This is a useful, comprehensive, systematic review of randomized controlled trials of the effect of various interventions in patients with COPD, including long-acting bronchodilators, inhaled corticosteroids, nocturnal noninvasive ventilation, pulmonary rehabilitation, domiciliary oxygen therapy, and disease management programs, on a variety of outcomes. Data from clinical trials from 1980 to May 2002 are included in the review.
  • 30
    • 1642493871 scopus 로고    scopus 로고
    • The role of long-acting bronchodilators in the management of stable COPD
    • Tashkin DP, Cooper CB: The role of long-acting bronchodilators in the management of stable COPD. Chest 2004; 125:249-259.
    • (2004) Chest , vol.125 , pp. 249-259
    • Tashkin, D.P.1    Cooper, C.B.2
  • 31
    • 0029031264 scopus 로고
    • Salmeterol and formoterol in partially reversible severe chronic obstructive pulmonary disease: A dose-response study
    • Cazzola M, Matera MG, Santangelo G, et al. Salmeterol and formoterol in partially reversible severe chronic obstructive pulmonary disease: a dose-response study. Respir Med 1995; 89:357-362.
    • (1995) Respir Med , vol.89 , pp. 357-362
    • Cazzola, M.1    Matera, M.G.2    Santangelo, G.3
  • 32
    • 0032822578 scopus 로고    scopus 로고
    • Formoterol and salmeterol in patients with reversible obstructive pulmonary disease: A crossover, placebo-controlled comparison of onset and duration of action
    • Celik G, Kayacan O, Beder S, et al. Formoterol and salmeterol in patients with reversible obstructive pulmonary disease: a crossover, placebo-controlled comparison of onset and duration of action. Respiration (Herrlisheim) 1999; 66:434-439.
    • (1999) Respiration (Herrlisheim) , vol.66 , pp. 434-439
    • Celik, G.1    Kayacan, O.2    Beder, S.3
  • 33
    • 0037234780 scopus 로고    scopus 로고
    • Cost-effectiveness of salmeterol in patients with chronic obstructive pulmonary disease: An economic evaluation
    • Jones PW, Wilson K, Sondhi S: Cost-effectiveness of salmeterol in patients with chronic obstructive pulmonary disease: an economic evaluation. Respir Med 2003; 97:20-26.
    • (2003) Respir Med , vol.97 , pp. 20-26
    • Jones, P.W.1    Wilson, K.2    Sondhi, S.3
  • 34
    • 0037274051 scopus 로고    scopus 로고
    • An economic assessment of inhaled formoterol dry powder versus ipratropium bromide pressurized metered dose inhaler in the treatment of chronic obstructive pulmonary disease
    • Hogan TJ, Geddes R, Gonzalez ER: An economic assessment of inhaled formoterol dry powder versus ipratropium bromide pressurized metered dose inhaler in the treatment of chronic obstructive pulmonary disease. Clin Ther 2003; 25:285-297.
    • (2003) Clin Ther , vol.25 , pp. 285-297
    • Hogan, T.J.1    Geddes, R.2    Gonzalez, E.R.3
  • 35
    • 0038467559 scopus 로고    scopus 로고
    • Cardiovascular safety of salmeterol in COPD
    • Ferguson GT, Funck-Bretano C, Fischer T, et al. Cardiovascular safety of salmeterol in COPD. Chest 2003; 123:1817-1824.
    • (2003) Chest , vol.123 , pp. 1817-1824
    • Ferguson, G.T.1    Funck-Bretano, C.2    Fischer, T.3
  • 36
    • 14044258873 scopus 로고    scopus 로고
    • note
    • This study conducted a pooled analysis of cardiovascular safety data from seven randomized, double-blind, controlled studies of 12 to 52 weeks that included salmeterol (n = 1410) and placebo (n = 1443) arms. Salmeterol was not found to increase the risk of cardiovascular adverse events.
  • 37
    • 0242575103 scopus 로고    scopus 로고
    • State of the art in β-agonist therapy: A safety review of long-acting agents
    • Rabe KF: State of the art in β-agonist therapy: a safety review of long-acting agents. Int J Clin Pract 2003; 57:689-697.
    • (2003) Int J Clin Pract , vol.57 , pp. 689-697
    • Rabe, K.F.1
  • 38
    • 2442442883 scopus 로고    scopus 로고
    • The pulmonary and extra-pulmonary effects of high-dose formoterol in COPD: A comparison with salbutamol
    • Goldkorn A, Diotto P, Burgess C, et al. The pulmonary and extra-pulmonary effects of high-dose formoterol in COPD: a comparison with salbutamol. Respirology 2004; 9:102-108.
    • (2004) Respirology , vol.9 , pp. 102-108
    • Goldkorn, A.1    Diotto, P.2    Burgess, C.3
  • 39
    • 0031810916 scopus 로고    scopus 로고
    • Cardiac effects of formoterol and salmeterol in patients suffering from COPD with preexisting cardiac arrhythmias and hypoxemia
    • Cazzola M, Imperatore F, Salzillo A, et al. Cardiac effects of formoterol and salmeterol in patients suffering from COPD with preexisting cardiac arrhythmias and hypoxemia. Chest 1998; 114:411-415.
    • (1998) Chest , vol.114 , pp. 411-415
    • Cazzola, M.1    Imperatore, F.2    Salzillo, A.3
  • 40
    • 0034108346 scopus 로고    scopus 로고
    • The risk of myocardial infarction associated with inhaled beta-adrenoceptor agonists
    • Au DH, Lemaitre RN, Curtis JR, et al. The risk of myocardial infarction associated with inhaled beta-adrenoceptor agonists. Am J Respir Crit Care Med 2000; 161:827-830.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 827-830
    • Au, D.H.1    Lemaitre, R.N.2    Curtis, J.R.3
  • 41
    • 2942744546 scopus 로고    scopus 로고
    • Cardiovascular effects of β-agonists in patients with asthma and COPD
    • Salpeter SR, Ormiston TM, Salpeter ED: Cardiovascular effects of β-agonists in patients with asthma and COPD. Chest 2004; 125:2309-2321.
    • (2004) Chest , vol.125 , pp. 2309-2321
    • Salpeter, S.R.1    Ormiston, T.M.2    Salpeter, E.D.3
  • 42
    • 14044269007 scopus 로고    scopus 로고
    • note
    • 2-agonists increased heart rate and reduced serum potassium levels significantly, whereas multiple doses significantly increased the risk for a cardiovascular event compared with placebo.
  • 44
    • 70349207545 scopus 로고    scopus 로고
    • Tiotropium (Spiriva) for COPD
    • Anon.: Tiotropium (Spiriva) for COPD. Med Lett Drugs Ther 2004; 46:41-42.
    • (2004) Med Lett Drugs Ther , vol.46 , pp. 41-42
  • 45
    • 1042292620 scopus 로고    scopus 로고
    • One-year cost-effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease
    • Oostenbrink JB, Rutten-van Moklen MJ, van Noord JA, et al. One-year cost-effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease. Eur Respir J 2004; 23:241-249.
    • (2004) Eur Respir J , vol.23 , pp. 241-249
    • Oostenbrink, J.B.1    Rutten-van Moklen, M.J.2    Van Noord, J.A.3
  • 46
    • 0036181956 scopus 로고    scopus 로고
    • A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
    • Casaburi R, Mahler DA, Jones PW, et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J 2002; 19:217-224.
    • (2002) Eur Respir J , vol.19 , pp. 217-224
    • Casaburi, R.1    Mahler, D.A.2    Jones, P.W.3
  • 47
    • 3242888951 scopus 로고    scopus 로고
    • Healthcare costs with tiotropium plus usual care versus usual care alone following 1 year of treatment in patients with chronic obstructive pulmonary disorder (COPD)
    • Friedman M, Menjoge SS, Anton SF, et al. Healthcare costs with tiotropium plus usual care versus usual care alone following 1 year of treatment in patients with chronic obstructive pulmonary disorder (COPD). Pharmacoeconomics 2004; 22:741-749.
    • (2004) Pharmacoeconomics , vol.22 , pp. 741-749
    • Friedman, M.1    Menjoge, S.S.2    Anton, S.F.3
  • 48
    • 0031760347 scopus 로고    scopus 로고
    • Measurement of symptoms, lung hyperinflation and endurance during exercise in chronic obstructive pulmonary disease
    • O'Donnell DE, Lam M, Webb KA: Measurement of symptoms, lung hyperinflation and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 158:1557-1565.
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 1557-1565
    • O'Donnell, D.E.1    Lam, M.2    Webb, K.A.3
  • 49
    • 0033925684 scopus 로고    scopus 로고
    • Factor analysis of changes in dyspnea and lung function parameters after bronchodilation in chronic obstructive pulmonary disease
    • Taube C, Lehnigk B, Paasch K, et al. Factor analysis of changes in dyspnea and lung function parameters after bronchodilation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000; 162:216-220.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 216-220
    • Taube, C.1    Lehnigk, B.2    Paasch, K.3
  • 50
    • 0036282830 scopus 로고    scopus 로고
    • Volume effect and exertional dyspnoea after bronchodilator in patients with COPD with and without expiratory flow limitation at rest
    • Boni E, Corda L, Franchini D, et al. Volume effect and exertional dyspnoea after bronchodilator in patients with COPD with and without expiratory flow limitation at rest. Thorax 2002; 57:528-532.
    • (2002) Thorax , vol.57 , pp. 528-532
    • Boni, E.1    Corda, L.2    Franchini, D.3
  • 51
    • 2542474045 scopus 로고    scopus 로고
    • Effects of formoterol and salmeterolon resting inspiratory capacity in COPD patients with poor FEV1 reversibility
    • Bouros D, Kottakis J, Le Gros V, et al. Effects of formoterol and salmeterolon resting inspiratory capacity in COPD patients with poor FEV1 reversibility. Curr Med Res Opin 2004; 20:581-586.
    • (2004) Curr Med Res Opin , vol.20 , pp. 581-586
    • Bouros, D.1    Kottakis, J.2    Le Gros, V.3
  • 52
    • 0015241765 scopus 로고
    • Inhibition of mucociliary clearance from the human lung by hyoscine
    • Pavia D, Thomson ML: Inhibition of mucociliary clearance from the human lung by hyoscine. Lancet 1971; 1:449-450.
    • (1971) Lancet , vol.1 , pp. 449-450
    • Pavia, D.1    Thomson, M.L.2
  • 53
    • 0017290878 scopus 로고
    • Effects of atropine on velocity of tracheal mucus in anesthetized patients
    • Annis P, Landa J, Lichtiger M: Effects of atropine on velocity of tracheal mucus in anesthetized patients. Anaesthesiology 1976; 44:74-77.
    • (1976) Anaesthesiology , vol.44 , pp. 74-77
    • Annis, P.1    Landa, J.2    Lichtiger, M.3
  • 54
    • 0017685986 scopus 로고
    • Ipratropium bromide: Mucociliary clearance rate and airway resistance in normal subjects
    • Francis RA, Thomson ML, Pavia D, et al. Ipratropium bromide: mucociliary clearance rate and airway resistance in normal subjects. Br J Dis Chest 1977; 71:173-178.
    • (1977) Br J Dis Chest , vol.71 , pp. 173-178
    • Francis, R.A.1    Thomson, M.L.2    Pavia, D.3
  • 55
    • 0020624428 scopus 로고
    • Acute effect of ipratropium bromide at therapeutic dose on mucus transport of adult asthmatics
    • Foster WM, Langenback EG, Glaser ML, et al. Acute effect of ipratropium bromide at therapeutic dose on mucus transport of adult asthmatics. Eur J Respir Dis 1983; 64:544-557.
    • (1983) Eur J Respir Dis , vol.64 , pp. 544-557
    • Foster, W.M.1    Langenback, E.G.2    Glaser, M.L.3
  • 56
    • 2442516033 scopus 로고    scopus 로고
    • The effect of tiotropium bromide on lung mucociliary clearance in patients with COPD
    • Hasani A, Toms N, Agnew JE, et al. The effect of tiotropium bromide on lung mucociliary clearance in patients with COPD. Chest 2004; 125:1726-1734.
    • (2004) Chest , vol.125 , pp. 1726-1734
    • Hasani, A.1    Toms, N.2    Agnew, J.E.3
  • 57
    • 0036305399 scopus 로고    scopus 로고
    • A 6-month placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol
    • Donohue JF, van Noord JA, Bateman ED, et al. A 6-month placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest 2002; 122:47-55.
    • (2002) Chest , vol.122 , pp. 47-55
    • Donohue, J.F.1    Van Noord, J.A.2    Bateman, E.D.3
  • 58
    • 0042882845 scopus 로고    scopus 로고
    • Tolerance to bronchodilating effects of salmeterol in COPD
    • Donohue JF, Menjoge S, Kesten S: Tolerance to bronchodilating effects of salmeterol in COPD. Respir Med 2003; 97:1014-1020.
    • (2003) Respir Med , vol.97 , pp. 1014-1020
    • Donohue, J.F.1    Menjoge, S.2    Kesten, S.3
  • 59
    • 0038366897 scopus 로고    scopus 로고
    • Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD
    • Brusasco V, Hodder R, Miravitlles M, et al. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003; 58:399-404.
    • (2003) Thorax , vol.58 , pp. 399-404
    • Brusasco, V.1    Hodder, R.2    Miravitlles, M.3
  • 60
    • 14044252379 scopus 로고    scopus 로고
    • note
    • This report presents the data from two 6-month randomized, double-blind, placebo-controlled trials comparing tiotropium head-to-head with salmeterol in COPD patients. It is one of the only two published direct comparison studies with salmeterol in COPD and complements the report of Donohue et al. [54]. Tiotropium was significantly more effective than salmeterol in improving lung function and was numerically superior to salmeterol in improving quality of life and breathlessness and delaying the time to the first exacerbation, outcomes for which tiotropium, but not salmeterol, was significantly different from placebo.
  • 61
    • 0037445151 scopus 로고    scopus 로고
    • Theophylline: New perspectives for an old drug
    • Barnes PJ: Theophylline: new perspectives for an old drug. Am J Respir Crit Care Med 2003; 167:813-818.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 813-818
    • Barnes, P.J.1
  • 62
    • 14044253737 scopus 로고    scopus 로고
    • note
    • This review article provides a fresh perspective on the bronchodilator and anti-inflammatory effects of theophylline, including the purported mechanisms of action of theophylline, such as activation of histone deacetylases that influence the action of corticosteroids. The author also points out the possible unique utility of theophylline in COPD in view of its anti-inflammatory effects and its possible role in reversing steroid resistance induced by oxidative stress.
  • 63
    • 0021246617 scopus 로고
    • Effects of theophylline on diaphragmatic strength and fatigue in patients with chronic obstructive pulmonary disease
    • Murciano D, Aubier M, Lecocguic Y, et al. Effects of theophylline on diaphragmatic strength and fatigue in patients with chronic obstructive pulmonary disease. N Engl J Med 1984; 311:349-353.
    • (1984) N Engl J Med , vol.311 , pp. 349-353
    • Murciano, D.1    Aubier, M.2    Lecocguic, Y.3
  • 64
    • 0023220964 scopus 로고
    • Theophylline and mucociliary clearance
    • Ziment I: Theophylline and mucociliary clearance. Chest 1987; 92:38S-43S.
    • (1987) Chest , vol.92
    • Ziment, I.1
  • 65
    • 0022995590 scopus 로고
    • Theophylline improves global cardiac function and reduces dyspnea in chronic obstructive pulmonary disease
    • Mathay RA, Mahler DA: Theophylline improves global cardiac function and reduces dyspnea in chronic obstructive pulmonary disease. J Allergy Clin Immunol 1986; 78:793-799.
    • (1986) J Allergy Clin Immunol , vol.78 , pp. 793-799
    • Mathay, R.A.1    Mahler, D.A.2
  • 66
    • 0036206172 scopus 로고    scopus 로고
    • Comparison of the efficacy, tolerability, and safety of formoterol dry powder and oral, slow-release theophylline in the treatment of COPD
    • Rossi A, Kristufek P, Levine BE, et al. Comparison of the efficacy, tolerability, and safety of formoterol dry powder and oral, slow-release theophylline in the treatment of COPD. Chest 2002; 121:1058-1069.
    • (2002) Chest , vol.121 , pp. 1058-1069
    • Rossi, A.1    Kristufek, P.2    Levine, B.E.3
  • 67
    • 0034892541 scopus 로고    scopus 로고
    • Salmeterol plus theophylline combination therapy in the treatment of COPD
    • ZuWallack RL, Mahler DA, Reilly D, et al. Salmeterol plus theophylline combination therapy in the treatment of COPD. Chest 2001; 119:1661-1670.
    • (2001) Chest , vol.119 , pp. 1661-1670
    • Zuwallack, R.L.1    Mahler, D.A.2    Reilly, D.3
  • 68
    • 0032515756 scopus 로고    scopus 로고
    • Multicentre randomized placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease: International COPD Study Group
    • Paggiaro PL, Dahl R, Bakran I, et al. Multicentre randomized placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease: International COPD Study Group. Lancet 1998; 351:773-780.
    • (1998) Lancet , vol.351 , pp. 773-780
    • Paggiaro, P.L.1    Dahl, R.2    Bakran, I.3
  • 69
    • 0032973833 scopus 로고    scopus 로고
    • A double-blind placebo-controlled study of the effect of inhaled beclomethasone dipropionate for 2 years in patients with nonasthmatic chronic obstructive pulmonary disease
    • Weir DC, Bale GA, Bright P, et al. A double-blind placebo-controlled study of the effect of inhaled beclomethasone dipropionate for 2 years in patients with nonasthmatic chronic obstructive pulmonary disease. Clin Exp Allergy 1999; 29:S125-S128.
    • (1999) Clin Exp Allergy , vol.29
    • Weir, D.C.1    Bale, G.A.2    Bright, P.3
  • 70
    • 0031749414 scopus 로고    scopus 로고
    • Randomized controlled trial of inhaled corticosteroids in patients with chronic obstructive pulmonary disease
    • Bourbeau J, Rouleau MY, Boucher S: Randomized controlled trial of inhaled corticosteroids in patients with chronic obstructive pulmonary disease. Thorax 1998; 53:477-482.
    • (1998) Thorax , vol.53 , pp. 477-482
    • Bourbeau, J.1    Rouleau, M.Y.2    Boucher, S.3
  • 71
    • 0037111198 scopus 로고    scopus 로고
    • Effect of discontinuing inhaled corticosteroids in patients with chronic obstructive pulmonary disease: The COPE study
    • van der Valk P, Monninkhof E, van der Palin J, et al. Effect of discontinuing inhaled corticosteroids in patients with chronic obstructive pulmonary disease: the COPE study. Am J Respir Crit Care Med 2002; 166:1358-1363.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1358-1363
    • Van Der Valk, P.1    Monninkhof, E.2    Van Der Palin, J.3
  • 72
    • 0345188819 scopus 로고    scopus 로고
    • Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease
    • Pauwels RA, Lofdahl CG, Laitinen LA, et al. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. N Engl J Med 1999; 340:1948-1953.
    • (1999) N Engl J Med , vol.340 , pp. 1948-1953
    • Pauwels, R.A.1    Lofdahl, C.G.2    Laitinen, L.A.3
  • 73
    • 0033614639 scopus 로고    scopus 로고
    • Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: A randomized controlled trial
    • Vestbo J, Sorensen T, Lange P, et al. Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomized controlled trial. Lancet 1999; 353:1819-1823.
    • (1999) Lancet , vol.353 , pp. 1819-1823
    • Vestbo, J.1    Sorensen, T.2    Lange, P.3
  • 74
    • 0034727828 scopus 로고    scopus 로고
    • Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. Lung Health Study II
    • The Lung Health Study Research Group: Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. Lung Health Study II. N Engl J Med 2000; 343:1902-1909.
    • (2000) N Engl J Med , vol.343 , pp. 1902-1909
  • 75
    • 0034643610 scopus 로고    scopus 로고
    • Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: The ISOLDE trial
    • Burge PS, Calverley PMA, Jones PW, et al. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. BMJ 2000; 320:1297-1303.
    • (2000) BMJ , vol.320 , pp. 1297-1303
    • Burge, P.S.1    Calverley, P.M.A.2    Jones, P.W.3
  • 76
    • 0037337674 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease 7: Management of COPD
    • MacNee W, Calverley PMA: Chronic obstructive pulmonary disease 7: management of COPD. Thorax 2003; 58:261-265.
    • (2003) Thorax , vol.58 , pp. 261-265
    • MacNee, W.1    Calverley, P.M.A.2
  • 77
    • 0036063208 scopus 로고    scopus 로고
    • The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: A systematic review of randomized placebo-controlled trials
    • Alsaeedi A, Sin DD, McAlister FA: The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials. Am J Med 2002; 113:59-65.
    • (2002) Am J Med , vol.113 , pp. 59-65
    • Alsaeedi, A.1    Sin, D.D.2    McAlister, F.A.3
  • 78
    • 0037108632 scopus 로고    scopus 로고
    • Effectiveness of fluticasone propionate and salmeterol combination delivered via the diskus device in the treatment of chronic obstructive pulmonary disease
    • Mahler DA, Wire P, Horstman D, et al. Effectiveness of fluticasone propionate and salmeterol combination delivered via the diskus device in the treatment of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002; 166:1084-1091.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1084-1091
    • Mahler, D.A.1    Wire, P.2    Horstman, D.3
  • 79
    • 0037425745 scopus 로고    scopus 로고
    • Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: A randomised controlled trial
    • Calverley P, Pauwels R, Vestbo J, et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003; 361:449-456.
    • (2003) Lancet , vol.361 , pp. 449-456
    • Calverley, P.1    Pauwels, R.2    Vestbo, J.3
  • 80
    • 0141558800 scopus 로고    scopus 로고
    • The efficacy and safety of fluticasone propionate (250 microg)/salmeterol (50 microg) combined in the Diskus inhaler for the treatment of COPD
    • Hanania NA, Darken P, Horstman D, et al. The efficacy and safety of fluticasone propionate (250 microg)/salmeterol (50 microg) combined in the Diskus inhaler for the treatment of COPD. Chest 2003; 124:834-843.
    • (2003) Chest , vol.124 , pp. 834-843
    • Hanania, N.A.1    Darken, P.2    Horstman, D.3
  • 81
    • 0037246566 scopus 로고    scopus 로고
    • Efficacy and safety of budesonide/ formoterol in the management of chronic obstructive disease
    • Szafranski W, Cukier A, Ramirez A, et al. Efficacy and safety of budesonide/ formoterol in the management of chronic obstructive disease. Eur Respir J 2003; 21:74-81.
    • (2003) Eur Respir J , vol.21 , pp. 74-81
    • Szafranski, W.1    Cukier, A.2    Ramirez, A.3
  • 82
    • 0347473812 scopus 로고    scopus 로고
    • Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease
    • Calverley PM, Boonsawat W, Cseke Z, et al. Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease. Eur Respir J 2003; 22:912-919.
    • (2003) Eur Respir J , vol.22 , pp. 912-919
    • Calverley, P.M.1    Boonsawat, W.2    Cseke, Z.3
  • 83
    • 6344240810 scopus 로고    scopus 로고
    • Skin manifestations of inhaled corticosteroids: Results from Lung Health Study II, a randomized controlled clinical trial
    • Tashkin DP, Murray R, Murray HE, et al. Skin manifestations of inhaled corticosteroids: results from Lung Health Study II, a randomized controlled clinical trial. Chest 2004; 126:1123-1133.
    • (2004) Chest , vol.126 , pp. 1123-1133
    • Tashkin, D.P.1    Murray, R.2    Murray, H.E.3
  • 84
    • 0035960123 scopus 로고    scopus 로고
    • Effects of inhaled glucocorticoids on bone density in premenopausal women
    • Israel E, Banerjee TR, Fitzmaurice GM, et al. Effects of inhaled glucocorticoids on bone density in premenopausal women. N Engl J Med 2001; 345:941-947.
    • (2001) N Engl J Med , vol.345 , pp. 941-947
    • Israel, E.1    Banerjee, T.R.2    Fitzmaurice, G.M.3
  • 85
    • 10644297273 scopus 로고    scopus 로고
    • Loss of bone density associated with the use of an inhaled corticosteroid in adults with chronic obstructive pulmonary disease: Lung Health Study II
    • Scanlon PD, Connett JE, Wise RA, et al., for the Lung Health Study Research Group: Loss of bone density associated with the use of an inhaled corticosteroid in adults with chronic obstructive pulmonary disease: Lung Health Study II. Am J Respir Crit Care Med 2004; 170:1302-1309.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 1302-1309
    • Scanlon, P.D.1    Connett, J.E.2    Wise, R.A.3
  • 86
    • 0037115164 scopus 로고    scopus 로고
    • Inhaled corticosteroids and hip fracture: A population-based case-control study
    • Hubbard RB, Smith CJ, Smeeth L, et al. Inhaled corticosteroids and hip fracture: a population-based case-control study. Am J Respir Crit Care Med 2002; 166:1563-1566.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1563-1566
    • Hubbard, R.B.1    Smith, C.J.2    Smeeth, L.3
  • 87
    • 0030859363 scopus 로고    scopus 로고
    • Use of inhaled corticosteroids and the risks of cataracts
    • Cumming RG, Mitchell P, Leader SR: Use of inhaled corticosteroids and the risks of cataracts. N Engl J Med 1997; 337:8-14.
    • (1997) N Engl J Med , vol.337 , pp. 8-14
    • Cumming, R.G.1    Mitchell, P.2    Leader, S.R.3
  • 88
    • 0031044736 scopus 로고    scopus 로고
    • Inhaled and nasal glucocorticoids and the risks of ocular hypertension or open-angle glaucoma
    • Garb E, Le Lorier J, Boivin FJ, et al. Inhaled and nasal glucocorticoids and the risks of ocular hypertension or open-angle glaucoma JAMA 1997; 277:722-727.
    • (1997) JAMA , vol.277 , pp. 722-727
    • Garb, E.1    Le Lorier, J.2    Boivin, F.J.3
  • 89
    • 0345414503 scopus 로고    scopus 로고
    • The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD
    • Cazzola M, Marco FD, Santus P, et al. The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD. Pulm Pharmacol Ther 2004; 17:35-39.
    • (2004) Pulm Pharmacol Ther , vol.17 , pp. 35-39
    • Cazzola, M.1    Marco, F.D.2    Santus, P.3
  • 90
    • 4243393253 scopus 로고    scopus 로고
    • Tiotropium maintenance therapy in patients with COPD and the 24-h spirometric benefit of adding once or twice daily formoterol during 2-week treatment periods
    • van Noord JA, Aumann J, Janssens E, et al. Tiotropium maintenance therapy in patients with COPD and the 24-h spirometric benefit of adding once or twice daily formoterol during 2-week treatment periods [abstract]. Am J Respir Crit Care Med 2003; 168:A95.
    • (2003) Am J Respir Crit Care Med , vol.168
    • Van Noord, J.A.1    Aumann, J.2    Janssens, E.3
  • 91
    • 0141654874 scopus 로고    scopus 로고
    • Comparison of once daily tiotropium, twice daily formoterol and the free combination, once daily, in patients with COPD
    • van Noord JA, Aumann J, Janssens E, et al. Comparison of once daily tiotropium, twice daily formoterol and the free combination, once daily, in patients with COPD [abstract]. Am J Respir Crit Care Med 2003; 168:A320.
    • (2003) Am J Respir Crit Care Med , vol.168
    • Van Noord, J.A.1    Aumann, J.2    Janssens, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.