Pulmonary disease in rescue workers at the World Trade Center site

Current Opinion in Pulmonary Medicine

Volumn 11, Issue 2, 2005, Pages 160-168

  Banauch, G I ^a,d   Dhala, A ^a,b   Prezant, D J ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b North Central Bronx Hospital   (United States)

^c Government of New york   (United States)

^d MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Construction workers; Firefighters; Gastroesophageal reflux disease; Nonspecific bronchial hyperreactivity; Reactive airway dysfunction syndrome; Reactive upper airway dysfunction syndrome; Rescue workers; World Trade Center

Indexed keywords

AIR POLLUTION; AIR QUALITY; BIOLOGICAL MONITORING; BRONCHUS HYPERREACTIVITY; CHRONIC RHINITIS; COUGHING; DISASTER; DUST EXPOSURE; GASTROINTESTINAL DISEASE; GASTROINTESTINAL REFLUX; HEALTH CARE; HUMAN; LOEFFLER PNEUMONIA; LUNG DISEASE; LUNG PARENCHYMA; MUCOSA INFLAMMATION; NONHUMAN; PNEUMONIA; POLLUTANT; RESCUE PERSONNEL; RESPIRATORY TRACT DISEASE; REVIEW;

EID: 14044256551     PISSN: 10705287     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mcp.0000151716.96241.0a     Document Type: Review

References (57)

1. 2.5 fraction.
2. Lioy PJ, Weisel CP, Millette JR, et al. Characterization of the dust/smoke aerosol that settled east of the World Trade Center (WTC) in lower Manhattan after the collapse of the WTC 11 September 2001. Environ Health Perspect 2002; 110:703-714.
3. Pleil JD, Vette AF, Johnson BA, Rappaport SM: Air levels of carcinogenic polycyclic aromatic hydrocarbons after the World Trade Center disaster. Proc Natl Acad Sci USA 2004; 101:11685-11688 (Epub 2004 Jul 27). This paper details the air levels and temporal trends of polycyclic aromatic hydrocarbons at the WTC site.
4. Potential exposures to airborne and settled surface dust in residential areas of lower Manhattan following the collapse of the World Trade Center-New York City, November 4-December 11, 2001. MMWR Morb Mortal Wkly Rep 2003; 52:131-136.
5. Toxicological Effects of Fine Particulate Matter Derived from the Destruction of the World Trade Center URL: http://www.epa.gov/nheerl/wtc/ WTC_report_7b3i.pdf 2004 A comprehensive review of the histopathological effects of the World Trade Center fine particulate matter.
6. Offenberg JH, Eisenreich SJ, Gigliotti CL, et al. Persistent organic pollutants in dusts that settled indoors in lower Manhattan after September 11, 2001. J Expo Anal Environ Epidemiol 2004; 14:164-172.
7. Betts K: WTC dust may cause respiratory problems. World Trade Center. Environ Sci Technol 2002; 36:273A.
8. Service RF: Chemical studies of 9/11 disaster tell complex tale of 'bad stuff'. Science 2003; 301:1640.
9. Yiin L, Millette JR, Vette A, et al. Comparisons of the dust/smoke particulate that settled inside the surrounding buildings and outside on the streets of southern New York City after the collapse of the World Trade Center, September 11, 2001. J Air Waste Manag Assoc 2004; 54:515-528. This study details the similarities and differences in the indoor and outdoor particulate matter, which is pertinent to evaluating and identifying health impact caused by indoor and outdoor exposures.
10. An Industrial Hygeine Survey Of an Office Building in the Vicinity of the World Trade Center: Assessment of potential hazards following the collapse of the World Trade Center buildings. Journal of Occupational and Environmental Hygiene 2004; D49-D53.
11. Swartz E, Stockburger L, Vallero DA: Polycyclic aromatic hydrocarbons and other semivolatile organic compounds collected in New York City in response to the events of 9/11. Environ Sci Technol 2003; 37:3537-3546.
12. Nordgren MD, Goldstein EA, Izeman MA: The Environmental Health Effects of the World Trade Center Attacks: A Preliminary Assessment. National Resources Defense Council, New York; February 2002.
13. Wilson WE, Suh HH: Fine particles and coarse particles: concentration relationships relevant to epidemiologic studies. J Air Waste Manage Assoc 1997; 47:1238-1249.
14. Offenberg JH, Eisenreich SJ, Ggliotti CL, et al. Persistent organic pollutants in dusts that settled indoors in lower Manhattan after September 11, 2001. J Expo Anal Environ Epidemiol 2004, 164-172.
15. From the Centers for Disease Control and Prevention: Occupational exposures to air contaminants at the World Trade Center disaster site - New York, September-October 2001; JAMA 2002, 287:3201-3202.
16. Prezant DJ, Weiden M, Banauch GI, et al. Cough and bronchial responsiveness in firefighters at the World Trade Center site. N Engl J Med 2002; 347:806-815 (Epub 2002 Sep 09).
17. Feldman DM, Baron SL, Bernard BP, et al. Symptoms, respirator use, and pulmonary function changes among New York City firefighters responding to the World Trade Center disaster. Chest 2004; 125:1256-1264. This study details the symptoms, changes in pulmonary function tests, and respirator use and disuse in New York City firefighters, three weeks following the collapse of the World Trade Center.
18. Use of respiratory protection among responders at the World Trade Center site - New York City, September 2001. MMWR Morb Mortal Wkly Rep 2002; 51:6-8.
19. Toren K, Brisman J, Hagberg S, Karlsson G: Improved nasal clearance among pulp-mill workers after the reduction of lime dust. Scand J Work Environ Health 1996; 22:102-107.
20. Fireman EM, Lerman Y, Ganor E, et al. Induced Sputum Assessment in New York City Firefighters Exposed to World Trade Center Dust. Environ Health Perspect (in press).
21. Churg A: The uptake of mineral particles by pulmonary epithelial cells. Am J Respir Crit Care Med 1996; 154:1124-1140.
22. Chen LC, Thurston G: World Trade Center cough. Lancet 2002; 360(suppl):s37-s38.
23. Banauch GI, Alleyne D, Sanchez R, et al. Persistent hyperreactivity and reactive airway dysfunction in firefighters at the World Trade Center. Am J Respir Crit Care Med 2003; 168:54-62. This is a prospective longitudinal study using a sample of firefighters divided on the basis of their exposure intensity, which was used as a tool to predict the development of reactive airway dysfunction syndrome at 6 months post exposure. A dose-response gradient between WTC dust exposure and nonspecific hyperreactivity lasted up to 6 months after the disaster.
24. Salzman SH, Moosavy FM, Miskoff JA, et al. Early respiratory abnormalities in emergency services police officers at the World Trade Center site. J Occup Environ Med 2004; 46:113-122 (Epub 2003 Feb 25). This study details the respiratory symptoms, spirometric abnormalities, and the relationship between exposure intensity (post World Trade Center Collapse), previous pulmonary disease, and pulmonary symptoms in police first-responders.
25. Skloot G, Goldman M, Fischler D, et al. Respiratory symptoms and physiologic assessment of ironworkers at the World Trade Center disaster site. Chest 2004; 125:1248-1255. A cross-sectional study conducted in a sample of ironworkers at the World Trade Center site to characterize the respiratory abnormalities after dust exposure in this cohort.
26. Gil L, Martinez V, Riquelme R, et al. Occupational and environmental levels of mutagenic PAHs and respirable particulate matter associated with diesel exhaust in Santiago, Chile. J Occup Environ Med 2003; 45:984-992.
27. Edelman P, Osterloh J, Pirkle J, et al. Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse. Environ Health Perspect 2003; 111:1906-1911. This is a cross-sectional study that assesses the internal dose exposures of the hazardous World Trade Center smoke and dust by biological monitoring of the blood and urine of firefighters.
28. Lakowicz JR, Bevan DR: Benzo[a]pyrene uptake into rat liver microsomes: effects of adsorption of benzo[a]pyrene to asbestos and non-fibrous mineral particles. Chem Biol Interact 1980; 29:129-138.
29. Gerde P, Scholander P: Adsorption of polycyclic aromatic hydrocarbons on to asbestos and man-made mineral fibers in the gas phase. IARC Sci Publ 1989; 90:140-148.
30. Lentz TJ, Rice CH, Succop PA, et al. Pulmonary deposition modeling with airborne fiber exposure data: a study of workers manufacturing refractory ceramic fibers. Appl Occup Environ Hyg 2003; 18:278-288.
31. Hesterberg TW, Hart GA: Synthetic vitreous fibers: a review of toxicology research and its impact on hazard classification. Crit Rev Toxicol 2001; 31:1-53.
32. Gavett SH, Haykal-Coates N, Highfill JW, et al. World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice. Environ Health Perspect 2003; 111:981-991. The objective of this study was to examine the respiratory effects of fine World Trade Center particulate matter on young adult female mice, and compare its effects with a toxic and a nontoxic reference material. Compared to the reference materials, WTC particulate caused only mild pulmonary inflammation, but a striking degree of airway hyperresponsiveness.
33. New York City Department of Health and Mental Hygiene and Agency for Toxic Substances and Disease Registry U.S. Department of Health and Human Services: Final Technical Report of the Public Health Investigation to Assess Potential Exposures to Airborne and Settled Surface Dust in Residential Areas of Lower Manhattan. September 2002. Available at: http://www.atsdr.cdc.gov/ asbestos/final-report-lowermanhattan-02-execsummary.html.
34. From the Centers for Disease Control and Prevention: Self-reported increase in asthma severity after the September 11 attacks on the World Trade Center-Manhattan, New York, 2001. JAMA 2002, 288:1466-1467.
35. Bernard BP, Baron SL, Mueller CA, et al. Impact of September 11 attacks on workers in the vicinity of the World Trade Center - New York City. MMWR 2002; 51:8-10.
36. Bardana EJ Jr: Reactive airways dysfunction syndrome (RADS): guidelines for diagnosis and treatment and insight into likely prognosis. Ann Allergy Asthma Immunol 1999; 83:583-586.
37. Henneberger PK, Derk SJ, Davis L, et al. Work-related reactive airways dysfunction syndrome cases from surveillance in selected US states. J Occup Environ Med 2003; 45:360-368.
38. Hickman MA, Nelson ED, Siegel EG, Bernstein JA: Are high-dose toxic exposures always associated with reactive airways dysfunction syndrome (RADS). Arch Environ Health 2001; 56:439-442.
39. Demeter SL, Cordasco EM, Guidotti TL: Permanent respiratory impairment and upper airway symptoms despite clinical improvement in patients with reactive airways dysfunction syndrome. Sci Total Environ 2001; 270:49-55.
40. Meggs WJ, Elsheik T, Metzger WJ, et al. Nasal pathology and ultrastructure in patients with chronic airway inflammation (RADS and RUDS) following an irritant exposure. J Toxicol Clin Toxicol 1996; 34:383-396.
41. Levin S, Herbert R, Skloot G, et al. Health effects of World Trade Center site workers. Am J Ind Med 2002; 42:545-547.
42. Centers for Disease Control and Prevention: Physical health status of World Trade Center rescue and recovery workers and volunteers - New York City, July 2002-August 2004. MMWR Morb Mortal Wkly Rep 2004, 53:807-812. WTC-related new or persistently worsened upper and lower respiratory symptoms are described in 74% and 60% of 1138 participants examined from 07/16/2002 to 08/06/2004 in the WTC Worker and Volunteer Medical Screening Program. In addition, abnormal spirometric findings (obstruction in 7%, pseudo-restriction in 11%, bronchodilator response in 23%) are also reported in a significant number.
43. Lieberman AD, Craven MR: Reactive intestinal dysfunction syndrome (RIDS) caused by chemical exposures. Arch Environ Health 1998; 53:354-358.
44. Harding SM: Acid reflux and asthma. Curr Opin Pulm Med 2003; 9:42-45.
45. Canning BJ, Mazzone SB: Reflex mechanisms in gastroesophageal reflux disease and asthma. Am J Med 2003; 115(suppl 3A):45S-48S.
46. Rom WN, Weiden M, Garcia R, et al. Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dust. Am J Respir Crit Care Med 2002; 166:797-800.
47. Safirstein BH, Klukowicz A, Miller R, Teirstein A: Granulomatous pneumonitis following exposure to the World Trade Center collapse. Chest 2003; 123:301-304. A report of a sentinel case of granulomatous pneumonitis in a 37-year-old male engineer, nonsmoker, without prior history of respiratory disorder, exposed to the World Trade Center dust.
48. Prezant DJ, Dhala A, Goldstein A, et al. The incidence, prevalence, and severity of sarcoidosis in New York City firefighters. Chest 1999; 116:1183-1193.
49. Landrigan PJ, Lioy PJ, Thurston G, et al. NIEHS World Trade Center Working Group. Health and environmental consequences of the World Trade Center disaster. Environ Health Perspect 2004; 112:731-739. A comprehensive review of the health consequences of the World Trade Center dust in firefighters, cleanup and recovery workers, community residents, and pregnant women and their offspring.
50. Malo JL, Cartier A, Boulet LP, et al. Bronchial hyperresponsiveness can improve while spirometry plateaus two to three years after repeated exposure to chlorine causing respiratory symptoms. Am J Respir Crit Care Med 1994; 150:1142-1145.
51. Szema AM, Khedkar M, Maloney PF, et al. Clinical deterioration in pediatric asthmatic patients after September 11, 2001. J Allergy Clin Immunol 2004; 113:420-426.
52. Cone JE, Wugofski L, Balmes JR, et al. Persistent respiratory health effects after a metam sodium pesticide spill. Chest 1994; 106:500-508.
53. Malo JL, Lemiere C, Gautrin D, Labrecque M: Occupational asthma. Curr Opin Pulm Med 2004; 10:57-61.
54. Chan-Yeung M, Malo JL: Aetiological agents in occupational asthma. Eur Respir J 1994; 7:346-371.
55. Mapp C, Boschetto P, Miotto D, et al. Mechanisms of occupational asthma. Ann Allergy Asthma Immunol 1999; 83:645-664.
56. Mihalas LS: An approach to the diagnosis of occupational asthma. Ann Allergy Asthma Immunol 1999; 83:577-582.
57. Perfetti L, Brame B, Ferrari M, Moscato G: Occupational asthma (OA) with sensitization to diphenylmethane diisocyanate (MDI) presenting at the onset like a reactive airways dysfunction syndrome (RADS). Am J Ind Med 2003; 44:325-328.