The mechanism of ring enhancement in hepatocellular carcinoma on superparamagnetic iron oxide-enhanced T1-weighted images: An investigation into peritumoral Kupffer cells

Journal of Magnetic Resonance Imaging

Volumn 21, Issue 3, 2005, Pages 230-236

  Tanimoto, Akihiro ^a   Wakabayashi, Go ^a   Shinmoto, Hiroshi ^a   Okuda, Shigeo ^a   Kuribayashi, Sachio ^a   Mukai, Makio ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Contrast media, magnetic resonance imaging; Iron, contrast media; Liver, hepatocellular carcinoma; Liver, Kupffer cell; Magnetic resonance imaging, liver; Superparamagnetic iron oxide

Indexed keywords

CONTRAST MEDIUM; IRON OXIDE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENHANCER REGION; FEMALE; HUMAN; KUPFFER CELL; LIVER CELL CARCINOMA; LIVER PARENCHYMA; MALE; MEDICAL ASSESSMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PHAGOCYTOSIS; PRIORITY JOURNAL;

AGED; ANALYSIS OF VARIANCE; CARCINOMA, HEPATOCELLULAR; CONTRAST MEDIA; FEMALE; HUMANS; IMAGE ENHANCEMENT; IRON; KUPFFER CELLS; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OBSERVER VARIATION; OXIDES; PREDICTIVE VALUE OF TESTS;

EID: 14044255923     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmri.20263     Document Type: Article

References (19)

1. Chambon C, Clement O, Le Blanche A, Schouman-Claeys E, Frija G. Superparamagnetic iron oxides as positive MR contrast agents: in vitro and in vivo evidence. Magn Reson Imaging 1993;11:509-519.
2. Mergo PJ, Engelken JD, Helmberger T, Ros PR. MRI in focal liver disease: a comparison of small and ultra-small superparamagnetic iron oxide as hepatic contrast agents. J Magn Reson Imaging 1998;8:1073-1078.
3. Takahama K, Amano Y, Hayashi H, Ishihara M, Kumazaki T. Detection and characterization of focal liver lesions using superparamagnetic iron oxide-enhanced magnetic resonance imaging: comparison between ferumoxides-enhanced T1-weighted imaging and delayed-phase gadolinium-enhanced T1-weighted imaging. Abdom Imaging 2003;28:525-530.
4. Lee JM, Kim CS, Youk JH, Lee MS. Characterization of focal liver lesions with superparamagnetic iron oxide-enhanced MR imaging: value of distributional phase T1-weighted imaging. Korean J Radiol 2003;4:9-18.
5. Mergo PJ, Helmberger T, Nicolas AI, Ros PR. Ring enhancement in ultrasmall superparamagnetic ion oxide MR imaging: a potential new sign for characterization of liver lesions. AJR Am J Roentgenol 1996;166:379-384.
6. Reimer P, Tombach B. Hepatic MRI with SPIO: detection and characterization of focal liver lesions. Eur Radiol 1998;8:1198-1204.
7. Kanematsu M, Matsuo M, Yamada Y, et al. Perilesional hyperintense rim of malignant hepatic tumors on ferumoxide-enhanced T1-weighted gradient-echo MR images: correlation between MR imaging and histopathologic findings. J Magn Reson Imaging 2003;18:40-48.
8. Tanimoto A, Oshio K, Suematsu M, Pouliquen D, Stark DD. Relaxation effects of clustered particles. J Magn Reson Imaging 2001;14:72-77.
9. Tanimoto A, Pouliquen D, Kreft BP, Stark DD: Effects of spatial distribution on proton relaxation enhancement by particulate iron oxide. J Magn Reson Imaging 1994;4:653-657.
10. Jung CW, Jacobs P. Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: ferumoxides, ferumoxtran, ferumoxsil. Magn Reson Imaging 1995;13:661-674.
11. Grangier C, Tourniaire J, Mentha G, et al. Enhancement of liver hemangiomas on T1-weighted MR SE images by superparamagnetic iron oxide particles. J Comput Assist Tomogr 1994;18:888-896.
12. van Gansbeke D, Metens TM, Matos C, et al. Effects of AM1-25 on liver vessels and tumors on T1-weighted turbo-field-echo images: implications for tumor characterization. J Magn Reson Imaging 1997;7:482-489.
13. Matsuo M, Kanematsu M, Itoh K, et al. Detection of malignant hepatic tumors with ferumoxides-enhanced MRI: comparison of five gradient-recalled echo sequences with different TEs. AJR Am J Roentgenol 2004;182:235-242.
14. Nakayama M, Yamashita Y, Mitsuzaki K, et al. Improved tissue characterization of focal liver lesions with ferumoxide-enhanced T1 and T2-weighted MR imaging. J Magn Reson Imaging 2000;11:647-654.
15. Kim JH, Kim MJ, Suh SH, Chung JJ, Yoo HS, Lee JT. Characterization of focal hepatic lesions with ferumoxides-enhanced MR imaging: utility of T1-weighted spoiled gradient recalled echo images using different echo times. J Magn Reson Imaging 2002;15:573-583.
16. Semelka RC, Hussain SM, Marcos HB, Woosley JT. Perilesional enhancement of hepatic metastases: correlation between MR imaging and histopathologic findings-initial observations. Radiology 2000;215:89-94.
17. Gabata T, Kadoya M, Matsui O, et al. Peritumoral spared area in fatty liver: correlation between opposed-phase gradient-echo MR imaging and CT arteriography. Abdom Imaging 2001;26:384-389.
18. Oswald P, Clement O, Chambon C, Schouman-Claeys E, Frija G. Liver positive enhancement after injection of superparamagnetic nanoparticles: respective role of circulating and uptaken particles. Magn Reson Imaging 1997;15:1025-1031.
19. Tanimoto A, Yuasa Y, Shinmoto H, et al. Superparamagnetic iron oxide-mediated hepatic signal intensity change in patients with and without cirrhosis: pulse sequence effects and Kupffer cell function. Radiology 2002;222:661-666.