Improved tissue characterization of focal liver lesions with ferumoxide- enhanced T1 and T2-weighted MR imaging

Journal of Magnetic Resonance Imaging

Volumn 11, Issue 6, 2000, Pages 647-654

  Nakayama, Mauro ^a   Yamashita, Yasuyuki ^a   Mitsuzaki, Katsuhiro ^a   Yi, Tang ^a   Arakawa, Akihiko ^a   Katahira, Kazuhiro ^a   Nakayama, Yoshiharu ^a   Takahashi, Mutsumasa ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Contrast agent; Ferumoxides; Liver; MR imaging; SPIO

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; FEMALE; HUMAN; LIVER DISEASE; LIVER INJURY; LIVER METASTASIS; LIVER TUMOR; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ADULT; AGED; CONTRAST MEDIA; EVALUATION STUDIES; FEMALE; HUMANS; IMAGE ENHANCEMENT; IRON; LIVER; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OXIDES; SENSITIVITY AND SPECIFICITY;

EID: 0034089952     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/1522-2586(200006)11:6<647::AID-JMRI11>3.0.CO;2-F     Document Type: Article

References (21)

1. Bellin MF, Zaim S, Auberton E, et al. Liver metastases: safety and efficacy of detection with superparamagnetic iron oxide in MR imaging. Radiology 1994;193:657-663.
2. Hagspiel KD, Neidl KF, Eichenberger AC, Weder W, Marincek B. Detection of liver metastases: comparison of superparamagnetic iron oxide-enhanced and unenhanced MR imaging at 1.5 T with dynamic CT, intraoperative US, and percutaneous US. Radiology 1995;196:471-478.
3. Winter TC, Freeny PC. MR imaging with IV superparamagnetic iron oxide: efficacy in the detection of focal hepatic lesions. AJR 1993; 161:1191-1198.
4. Stark DD, Weissleder R, Elizondo G, et al. Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology 1988;168:297-301.
5. Ros PR, Freeny PC, Harms SE, et al. Hepatic MR imaging with ferumoxide: a multicenter clinical trial of safety and efficacy in the detection of focal hepatic lesions. Radiology 1995;196:482-488.
6. Harisinghani MG, Saini S, Weissleder R, et al. Differentiation of liver hemangiomas from metastases and hepatocellular carcinoma at MR imaging enhanced with blood-pool contrast agent Code-7227. Radiology 1997;202:687-691.
7. Saini S, Edelman RR, Sharma P, et al. Blood-pool MR contrast material for detection and characterization of focal hepatic lesions: initial clinical experience with ultrasmall superparamagnetic iron oxide (AMI-227). AJR 1995;164:1147-1152.
8. Duda S, Laniado M, Kopp A, et al. Superparamagnetic iron oxide: detection of focal liver lesions at high-field-strength MR imaging. J Magn Reson Imaging 1994;4:309-314.
9. Hahn PF, Stark DD, Weissleder R, et al. Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors. Radiology 1990;174:361-366.
10. Grangier C, Tourniaire J, Mentha G, et al. Enhancement of liver hemangiomas on T1-weighted MR SE images by superparamagnetic iron oxide particles. J Comput Assist Tomogr 1994;18:888-896.
11. van Gansbeke D, Metens TM, Matos C, et al. Effects of AMI-25 on liver vessels and tumors on T1-weighted turbo-field-echo images: implications for tumor characterization. J Magn Reson Imaging 1997;7:482-489.
12. Van Beers B, Gallez B, Pringot J. Contrast-enhanced MR imaging of the liver. Radiology 1997;203:297-306.
13. Heiken JP. Liver. In: Computed body tomography with MRI correlation. Philadelphia: Lippincott-Raven, 1998. p 701-777.
14. Hamm B, Thoeni RF, Gould RG, et al. Focal liver lesions: characterization with nonenhanced and dynamic contrast material-enhanced MR imaging. Radiology 1994;190:417-423.
15. Yamashita Y, Hatanaka Y, Yamamoto H, et al. Differential diagnosis of focal liver lesions: role of spin-echo and contrast-enhanced dynamic MR imaging. Radiology 1994;193:59-65.
16. Yoshida H, Itai Y, Ohtomo K, et al. Small hepatocellular carcinoma and cavernous hemangioma: differentiation with dynamic FLASH MR imaging with Gd-DTPA. Radiology 1989;171:339-342.
17. Rofsky NM, Weinreb JC, Bernardino ME, et al. Hepatocellular tumors: characterization with Mn-DPDP enhanced MR imaging. Radiology 1993;188:53-59.
18. Petersein J, Saini S, Weissleder R, Liver. II: Iron oxide-based reticuloendothelial contrast agents for MR imaging. Clinical review. Magn Reson Imaging Clin North Am 1996;4:53-60.
19. van Gansbeke D, Matos C, Metens TM. Vascular enhancement with superparamagnetic iron oxide. AJR 1996;167:813-814.
20. Mergo PJ, Helmberger T, Nicolas AI, Ros PR. Ring enhancement in ultrasmall superparamagnetic iron oxide MR imaging: a potential new sign for characterization of liver lesions. AJR 1996;166:379-384.
21. McFarland EG, Mayo SW, Saini S, et al. Hepatic hemangiomas and malignant tumors: improved differentiation with heavily T2-weighted conventional spin-echo MR imaging. Radiology 1994;193: 43-47.