MRI in focal liver disease: A comparison of small and ultrasmall superparamagnetic iron oxide as hepatic contrast agents

Journal of Magnetic Resonance Imaging

Volumn 8, Issue 5, 1998, Pages 1073-1078

  Mergo, Patricia J ^a   Engelken, John D ^a   Helmberger, T ^a,b   Ros, Pablo R ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Contrast; Liver; MRI; SPIO; USPIO

Indexed keywords

CONTRAST MEDIUM; SUPERPARAMAGNETIC IRON OXIDE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTRAST ENHANCEMENT; COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC IMAGING; FEMALE; HUMAN; IMAGE ANALYSIS; INTRAVENOUS DRUG ADMINISTRATION; LIVER CELL CARCINOMA; LIVER DISEASE; LIVER HYPERPLASIA; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ADENOMA, LIVER CELL; CARCINOMA, HEPATOCELLULAR; CONTRAST MEDIA; FEMALE; HUMANS; HYPERPLASIA; IRON; LIVER; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OXIDES; SUSPENSIONS;

EID: 0031787395     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmri.1880080511     Document Type: Article

References (17)

1. Saini S, Stark DD, Hahn PF, et al. Ferrite particles: a superparamagnetic MR contrast agent for enhanced detection of liver carcinoma. Radiology 1987; 162:217-222.
2. Saini S, Stark DD, Hahn PF, Wittenberg J, Brady TJ, Ferrucci JTJ. Ferrite particles: a superparamagnetic contrast agent for the reticuloendothelial system. Radiology 1987; 162:211-216.
3. Stark DD, Weissleder R, Elizondo G, et al. Superparamagnetic iron oxide: clinical application as a contrast for MR imaging of the liver. Radiology 1988; 168:297-301.
4. Duda SH, Laniado M, Kopp AF, et al. Superparamagnetic iron oxide: detection of focal liver lesions at high field strength MR imaging. J Magn Reson Imaging 1994; 4:309-314.
5. Fahlvik AK, Klaveness J, Stark DD. Iron oxides as MR imaging contrast agents. J Magn Reson Imaging 1993; 3:187-194.
6. Ferrucci JT, Stark DD. Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years. AJR 1990; 155:943-950.
7. Marchal G, Van Hecke P, Demaeral P. Detection of liver metastasis with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T. AJR 1989; 152:771-775.
8. Ros PR, Freeny PC, Harms SE, et al. Hepatic MR imaging with ferumoxides: a multicenter clinical trial of the safety and efficacy in the detection of focal hepatic lesions. Radiology 1995; 196: 481-488.
9. Winter TC, Freeny PC, Nghiem HV, et al. MR imaging with i.v. superparamagnetic iron oxide: efficacy in the detection of focal hepatic lesions. AJR 1993; 161(6):1191-1198.
10. Reimer P, Kwong KK, Weisskoff R, Cohen MS, Brady TJ, Weissleder R. Dynamic signal intensity changes in liver with superparamagnetic MR contrast agents. J Magn Reson Imaging 1992; 2:177-181.
11. Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 1990; 175:489-493.
12. McLachlan SJ, Morris MR, Lucas MA, et al. Phase I clinical evaluation of a new iron oxide MR contrast agent. J Magn Reson Imaging 1994; 4:301-307.
13. Small W, Nelson R, Bernardino M. Dual contrast enhancement of both T1- and T2-weighted sequences using ultrasmall superparamagnetic iron oxide. Magn Reson Imaging 1993; 11:645-654.
14. Bengele HH, Palmacci S, Rogers J, Jung CW, Crenshaw J, Josephson L. Biodistribution of BMS 180549 by different routes of administration. Magn Reson Imaging 1994; 12:433-442.
15. Saini S, Edelman RR, Sharma P, et al. Blood-pool MR contrast material for detection and characterization of focal hepatic lesions: initial clinical experience with ultrasmall superparamagnetic iron oxide (AMI-227). AJR 1995; 164:1147-1152.
16. Mergo PJ, Helmberger T, Nicolas AI, Ros PR. Ring enhancement in ultrasmall superparamagnetic iron oxide (USPIO) MRI: a potential new sign for characterization of liver lesions. AJR 1996; 166:379-384.
17. Mayo-Smith WW, Saini S, Slater G, Kaufman JA, Sharma P, Hahn PF. MR contrast material for vascular enhancement: value of superparamagnetic iron oxide. AJR 1996; 166:73-77.