DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo

Journal of Cell Biology

Volumn 168, Issue 4, 2005, Pages 575-585

  Barmchi, Mojgan Padash ^a   Rogers, Stephen ^b,c   Häcker, Udo ^a  

^a LUND UNIVERSITY   (Sweden)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATE; MYOSIN ADENOSINE TRIPHOSPHATASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ACTIN MYOSIN INTERACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLASTODERM; CELL DIVISION; CELL POLARITY; CELL SHAPE; CONTROLLED STUDY; CYTOSKELETON; DRHOGEF2 GENE; DROSOPHILA MELANOGASTER; EMBRYO; EMBRYO DEVELOPMENT; EPITHELIUM CELL; FEMALE; GASTRULATION; GENE; MALE; MORPHOGENESIS; MUSCLE CONTRACTILITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM;

ACTINS; ACTOMYOSIN; ANIMALS; BLASTODERM; CELL DIVISION; CELL POLARITY; CELL SHAPE; CYTOSKELETON; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; MICROFILAMENT PROTEINS; MUTATION; RHO GTP-BINDING PROTEINS;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 13944278366     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200407124     Document Type: Article

References (42)

1. Afshar, K., B. Stuart, and S.A. Wasserman. 2000. Functional analysis of the Drosophila diaphanous FH protein in early embryonic development. Development. 127:1887-1897.
2. Banerjee, J., and P.B. Wedegaertner. 2004. Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton. Mol. Biol. Cell. 15:1760-1775.
3. Barrett, K., M. Leptin, and J. Settleman. 1997. The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell. 91:905-915.
4. Bate, M., and A. Martinez Arias. 1993. The Development of Drosophila melanogaster. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 1558.
5. Brand, A.H., and N. Perrimon. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 118:401-415.
6. Chou, T.B., and N. Perrimon. 1996. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. Genetics. 144: 1673-1679.
7. Cooper, J.A., and D.P. Kiehart. 1996. Septins may form a ubiquitous family of cytoskeletal filaments. J. Cell Biol. 134:1345-1348.
8. Crawford, J.M., N. Harden, T. Leung, L. Lim, and D.P. Kiehart. 1998. Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function. Dev. Biol. 204:151-164.
9. Field, C.M., and B.M. Alberts. 1995. Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex. J. Cell Biol. 131:165-178.
10. Foe, V.E., and B.M. Alberts. 1983. Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis. J. Cell Sci. 61:31-70.
11. Fukata, Y., M. Amano, and K. Kaibuchi. 2001. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol. Sci. 22:32-39.
12. Fumoto, K., T. Uchimura, T. Iwasaki, K. Ueda, and H. Hosoya. 2003. Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge. Biochem. J. 370:551-556.
13. Grevengoed, E.E., D.T. Fox, J. Gates, and M. Peifer. 2003. Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. J. Cell Biol. 163:1267-1279.
14. Hacker, U., S. Nystedt, M.P. Barmchi, C. Horn, and E.A. Wimmer. 2003. piggy Bac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila. Proc. Natl. Acad. Sci. USA. 100:7720-7725.
15. Hacker, U., and N. Perrimon. 1998. DRhoGEF2 encodes a member of the Db1 family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev. 12:274-284.
16. Halsell, S.R., B.I. Chu, and O.P. Kiehart. 2000. Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. Genetics. 155:1253-1265.
17. Harden, N., M. Ricos, Y.M. Ong, W. Chia, and L. Lim. 1999. Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesis. J. Cell Sci. 112: 273-284.
18. Lehner, C.F. 1992. The pebble gene is required for cytokinesis in Drosophila. J. Cell Sci. 103:1021-1030.
19. Magie, C.R., M.R. Meyer, M.S. Gorsuch, and S.M. Parkhurst. 1999. Mutations in the Rho1 small GTPase disrupt morphogenesis and segmentation during early Drosophila development. Development. 126:5353-5364.
20. Magie, C.R., D. Pinto-Santini, and S.M. Parkhurst. 2002. Rhol interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development. 129:3771-3782.
21. Mazumdar, A., and M. Mazumdar. 2002. How one becomes many: blastoderm cellularization in Drosophila melanogaster. Bioessays. 24:1012-1022.
22. Mizuno, T., K. Tsutsui, and Y. Nishida. 2002. Drosophila myosin phosphatase and its role in dorsal closure. Development. 129:1215-1223.
23. Neufeld, T.P., and G.M. Rubin. 1994. The Drosophila peanut gene is required for cytokinesis and encodes a protein similar to yeast putative bud neck filament proteins. Cell. 77:371-379.
24. Nikolaidou, K.K., and K. Barrett. 2004. A Rho GTPase signaling pathway is used reiteratively in epithelial folding and potentially selects the outcome of Rho activation. Curr. Biol. 14:1822-1826.
25. Parks, S., and E. Wieschaus. 1991. The Drosophila gastrulation gene concertina encodes a G alpha-like protein. Cell. 64:447-458.
26. Postner, M.A., and E.F. Wieschaus. 1994. The nullo protein is a component of the actin-myosin network that mediates cellularization in Drosophila melanogaster embryos. J. Cell Sci. 107:1863-1873.
27. Prokopenko, S.N., A. Brumby, L. O'Keefe, L. Prior, Y. He, R. Saint, and H.J. Bellen. 1999. A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev. 13:2301-2314.
28. Rogers, S.L., U. Wiedemann, U. Häcker, C. Turck, and R.D. Vale. 2004. Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner. Curr. Biol. 14:1827-1833.
29. Royou, A., C. Field, J.C. Sisson, W. Sullivan, and R. Karess. 2004. Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryos. Mol. Biol. Cell. 15:838-850.
30. Schejter, E.D., and E. Wieschaus. 1993. bottleneck acts as a regulator of the microfilament network governing cellularization of the Drosophila embryo. Cell. 75:373-385.
31. Schumacher, S., T. Gryzik, S. Tannebaum, and H.A. Muller. 2004. The RhoGEF Pebble is required for cell shape changes during cell migration triggered by the Drosophila FGF receptor Heartless. Development. 131: 2631-2640.
32. Settleman, J. 2001. Rac 'n Rho: the music that shapes a developing embryo. Dev. Cell. 1:321-331.
33. Smallhorn, M., M.J. Murray, and R. Saint. 2004. The epithelial- mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor Pebble. Development. 131:2641-2651.
34. Strutt, D.I., U. Weber, and M. Mlodzik. 1997. The role of RhoA in tissue polarity and Frizzled signalling. Nature. 387:292-295.
35. Swanson, M.M., and C.A. Poodry. 1980. Pole cell formation in Drosophila melanogaster. Dev. Biol. 75:419-430.
36. Tan, C., B. Stronach, and N. Perrimon. 2003. Roles of myosin phosphatase during Drosophila development. Development. 130:671-681.
37. Theurkauf, W.E. 1994. Actin cytoskeleton. Through the bottleneck. Curr. Biol. 4:76-78.
38. Thomas, G.H., and D.P. Kiehart. 1994. β-heavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesis. Development. 120:2039-2050.
39. Van Aelst, L., and C. D'Souza-Schorey. 1997. Rho GTPases and signaling networks. Genes Dev. 11:2295-2322.
40. Winter, C.G., B. Wang, A. Ballew, A. Royou, R. Karess, J.D. Axelrod, and L. Luo. 2001. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell. 105:81-91.
41. Wissmann, A., J. Ingles, J.D. McGhee, and P.E. Mains. 1997. Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape. Genes Dev. 11:409-422.
42. Yoffe, K.B., A.S. Manoukian, E.L. Wilder, A.H. Brand, and N. Perrimon. 1995. Evidence for engrailed-independent wingless autoregulation in Drosophila. Dev. Biol. 170:636-650.