Novel 2-alkylamino-1,4-benzoxazine derivatives as potent neuroprotective agents: Structure-activity relationship studies

Journal of Medicinal Chemistry

Volumn 48, Issue 4, 2005, Pages 1282-1286

  Blattes, Estelle ^a   Lockhart, Brian ^b   Lestage, Pierre ^b   Schwendimann, Leslie ^c   Gressens, Pierre ^c   Fleury, Maurice Bernard ^a   Largeron, Martine ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

(5 HYDROXY 2 PIPERIDINO 3 SPIRO 1' CYCLOHEXYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 6 YL)(PHENYL)METHANONE; 2 AMINO 1,4 BENZOXAZINE DERIVATIVE; BENZOXAZINE DERIVATIVE; EXCITOTOXIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CYTOTOXICITY; DRUG SYNTHESIS; EXCITOTOXICITY; IN VITRO STUDY; NERVE CELL DEGENERATION; NEUROPROTECTION; OXIDATIVE STRESS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANIMALS, NEWBORN; BENZOXAZINES; CELL LINE; CEREBRAL PALSY; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MICE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 13944265298     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040874m     Document Type: Article

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