A practical synthesis of highly functionalized aryl nitriles through cyanation of aryl bromides employing heterogeneous Pd/C

Tetrahedron Letters

Volumn 46, Issue 11, 2005, Pages 1849-1853

  Hatsuda, Masanori ^a   Seki, Masahiko ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BROMINE DERIVATIVE; CARBON; NITRILE; PALLADIUM; PHOSPHINE DERIVATIVE; ZINC; ZINC BROMIDE;

ARTICLE; CATALYSIS; CATALYST; CYANATION; REACTION ANALYSIS; SYNTHESIS;

EID: 13944260543     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.01.098     Document Type: Article

References (32)

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27. Pd/C catalyst employed in this study was purchased from Degussa Japan Co., Ltd. and has the following chemical properties: impregnation depth, 200-500 nm (thick shell); reduction degree, 0-25%; Pd dispersion, 28%; water content, less than 3 wt %. The catalyst is commercially available at Degussa Japan Co., Ltd
28. 2 five times. The mixture was stirred at 80-125°C for 3-15 h. After completion of the reaction, the suspension was cooled down to room temperature, diluted with AcOEt (15 mL), and filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography or recrystallization to provide the desired product
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