A practical synthesis of (+)-biotin through palladium hydroxide on charcoal-catalyzed fukuyama coupling reaction

Heterocycles

Volumn 58, Issue , 2002, Pages 125-127

  Mori, Yoshikazu ^a   Seki, Masahiko ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 ETHOXY 5 OXOPENTYLZINC IODIDE; BIOTIN; CHARCOAL; PALLADIUM COMPLEX; PALLADIUM HYDROXIDE; THIOLACTONE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; HYDROGENATION; REACTION ANALYSIS; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0037159788     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-02-s(m)57     Document Type: Article

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14. 4 and evaporated. The residue dissolved in toluene (78 mL) was treated with p-toluenesulfonic acid monohydrate (590 mg, 3.1 mmol) and the mixture was stirred at 20°C for 1.5 h. The mixture was washed with water and evaporated. The residue was purified by silica gel column chromatography (hexane/AcOEt = 5:2) to give 3 (12.2 g, 87%).