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Volumn 41, Issue 26, 2000, Pages 5099-5101

Facile synthesis of (+)-biotin via Fukuyama coupling reaction

Author keywords

Palladium and compounds; Sulfur compounds; Vitamins; Zinc and compounds

Indexed keywords

BIOTIN; THIOLACTONE;

EID: 0034709617     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00781-4     Document Type: Article
Times cited : (42)

References (19)
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    • For a review, see: Clercq, P. J. D. Chem. Rev. 1997, 97, 1755.
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    • (1951) Chem Abstr. , vol.45
    • Goldberg, M.W.1    Sternbach, L.H.2
  • 6
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    • (b) US Patent 2,489,235, Nov. 22, 1949
    • (b) Goldberg, M. W.; Sternbach, L. H. US Patent 2,489,235, Nov. 22, 1949; Chem Abstr. 1951, 45, 186a.
    • (1951) Chem Abstr. , vol.45
    • Goldberg, M.W.1    Sternbach, L.H.2
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    • Holick, W.1    Pauling, H.2    Cottong, N.A.3
  • 13
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    • 4 and evaporated. The residue was purified by distillation (bp 85-87°C/3 mmHg) to give the iodide (434 g, 85%)
    • 4 and evaporated. The residue was purified by distillation (bp 85-87°C/3 mmHg) to give the iodide (434 g, 85%).
  • 16
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    • note
    • 25 +190.9 (c, 0.95, MeOH)).
  • 17
  • 18
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    • 1H NMR spectroscopy: enhancement (10%) of the signal of the C-3 hydrogen atom was observed in the compound 5 when the olefinic hydrogen was irradiated.
    • 1H NMR spectroscopy: enhancement (10%) of the signal of the C-3 hydrogen atom was observed in the compound 5 when the olefinic hydrogen was irradiated.


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