Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 6, 2005, Pages 2045-2053

  Franchetti, Palmarisa ^a   Cappellacci, Loredana ^a   Pasqualini, Michela ^a   Petrelli, Riccardo ^a   Jayaprakasan, Vetrichelvan ^b   Jayaram, Hiremagalur N ^b   Boyd, Donald B ^c   Jain, Manojkumar D ^c   Grifantini, Mario ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

Cytotoxicity; IMPDH inhibitors; TAD analogues

Indexed keywords

ADENINE DERIVATIVE; ADENOSINE KINASE; AMIDE; INOSINATE DEHYDROGENASE INHIBITOR; ISOENZYME; METHYL GROUP; PROPANE; THIAZOLE DERIVATIVE; TIAZOFURIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CATALYSIS; CATALYST; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS COUPLING REACTION; DRUG CONFORMATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IC 50; REACTION ANALYSIS; STATISTICAL SIGNIFICANCE; STRUCTURE ANALYSIS;

EID: 13844311803     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.01.007     Document Type: Article

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