Role of the ABC transporter Ste6 in cell fusion during yeast conjugation

Journal of Cell Biology

Volumn 135, Issue 3, 1996, Pages 741-751

  Elia, Lisa ^a   Marsh, Lorraine ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; FACTOR A; PHEROMONE;

ARTICLE; BACTERIUM CONJUGATION; CELL CONTACT; CELL FUSION; CELL WALL; GENE MUTATION; MATING; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; YEAST CELL;

ALLELES; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELL WALL; CHROMOSOME MAPPING; CONJUGATION, GENETIC; FUNGAL PROTEINS; GLYCOPROTEINS; LIPOPROTEINS; MUTATION; PEPTIDES; PHEROMONES; REPRODUCTION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ANALYSIS, DNA;

BACTERIA (MICROORGANISMS); SACCHAROMYCES CEREVISIAE;

EID: 0029826350     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.135.3.741     Document Type: Article

References (44)

1. Berkower, C., and S. Michaelis. 1991. Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily. EMBO (Eur. Mol. Biol. Organ.) J. 10:3777-3785.
2. Betz, R., and W. Duntze. 1979. Purification and partial characterization of a factor, a mating hormone produced by mating-type-a cells from Saccharomyces cerevisiae. Eur. J. Biochem. 95:469-475.
3. Byers, B., and L. Goetsch. 1975. Behavior of spindles and spindle plaques in the cell cycle and conjugation of Saccharomyces cerevisiae. J. Bacteriol. 124:511-523.
4. Chan, R.K., L.M. Melnick, L.C. Blair, and J. Thorner. 1983. Extracellular suppression allows mating by pheromone-deficient sterile mutants of Saccharomyces cerevisiae. J. Bacteriol. 155:903-906.
5. Chan, R.K., and C.A. Otte. 1982. Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and a factor pheromones. Mol. Cell. Biol. 2:11-20.
6. Conti, S.F., and T.D. Brock. 1965. Electron microscopy of cell fusion in conjugating Hansenula wingei. J. Bacteriol. 90:524-533.
7. Dietzel, C., and J. Kurjan. 1987. Pheromonal regulation and sequence of the Saccharomyces cerevisiae SST2 gene: a model for desensitization to pheromone. Mol. Cell. Biol. 7:4169-4177.
8. Eliasson, L., E. Renstrom, C. Ammala, P.-O. Berggren, A.M. Bertorello, K. Bokvist, A. Chilbalin, J.T. Deeny, P.R. Flatt, J. Gabel et al. 1996. PKC-dependent stimulation of exocytosis by sunfonylureas in pancreatic beta-cells. Science (Wash. DC). 271:813-815.
9. Elion, E., P.L. Grisafi, and G.R. Fink. 1990. FUS3 encodes a cdc2/CDC28-related kinase required for the transition from mitosis into conjugation. Cell. 60:649-664.
10. Elion, E.A., J. Trueheart, and G.R. Fink. 1995. Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation. J. Cell Biol. 130:1283-1296.
11. Ellis, R.E., J. Yuan, and H.R. Horvitz. 1991. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics. 129:79-94.
12. Fearon, K., V. McClendon, B. Bonetti, and D.M. Bedwell. 1994. Premature translation termination mutations are efficiently supressed in a highly conserved region of yeast Ste6p, a member of the ATP-binding cassette (ABC) transporter family. J. Biol. Chem. 269:17802-17808.
13. Fenno, J.C., A. Shaikh, G. Spatafora, and P. Fives-Taylor. 1995. The fimA locus of Streptococcus parasanguis encodes an ATP-binding membrane transport system. Molec. Microbiol. 15:849-863.
14. Higgins, C.F. 1995. The ABC of Channel regulation. Cell. 82:693-696.
15. Hoffman, C.S., and F. Winston. 1987. Ten min DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene (Amst.). 57:267-272.
16. Hyde, S.C., P. Emsley, M.J. Hartshorn, M.M. Mimmack, U. Gileadi, S.R. Pearce, M.P. Gallagher, D.R. Gill, R.E. Hubbard, and C.F. Higgins. 1990. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistiance and bacterial transport. Nature (Lond.). 346:362-365.
17. Jackson, C.L., and L.H. Hartwell. 1990. Courtship in S. cerevisiae: both cell types choose mating partners by responsing to the strongest pheromone signal. Cell. 63:1039-1051.
18. Kuchler, K., R.E. Sterne, and J. Thorner. 1989. Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells. EMBO (Eur. Mol. Biol. Organ.) J. 13:3973-3984.
19. Kunihara, L.J., C.T. Beh, M. Latterich, R. Schekman, and M.D. Rose. 1994. Nuclear congression and membrane fusion: two distinct events in the yeast karyogamy pathway. J. Cell Biol. 126:911-924.
20. Lipke, P.N., A. Taylor, and C.E. Ballou. 1976. Morphogenic effects of α-factor on Saccharomyces cerevisiae a cells. J. Bact. 127:610-621.
21. Lipke, P.N., D. Wojciechowicz, and J. Kurjan. 1989. AGα1 is the structural gene for the Saccharomyces cerevisiae α-agglutinin, a cell surface glycoprotein involved in cell-cell interactions during mating. Mol. Cell. Biol. 9: 3155-3165.
22. Luciani, M.-F. and G. Chimini. 1996. The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death. EMBO (Eur. Mol. Biol. Organ.) J. 15:226-235.
23. Manavalan, P., A.E. Smith, and J.M. McPherson. 1993. Sequence and structural homology among membrane-associated domains of CFTR and certain transporter proteins. J. Protein Chem. 12:279-290.
24. Marcus, S., G.A. Caldwell, D. Miller, C.-B. Xuc, F. Naider, and J.M. Becker. 1991. Significance of C-terminal cysteine modifications to the biological activity of the Saccharomyces cerevisiae a-factor mating pheromone. Mol. Cell. Biol. 11:3603-3612.
25. Marsh, L. 1991. Genetic analysis of G protein-coupled receptors and response in yeast. In Sensory Receptors and Signal Transduction. J. Spudich, editor. Wiley-Liss, Inc., New York. 209-231.
26. Marsh, L. 1992. Substitutions in the hydrophobic core of the alpha-factor receptor of Saccharomyces cerevisiae permit response to Saccharomyces kluyveri α-factor and to antagonist. Mol. Cell. Biol. 12:3959-3966.
27. Marsh, L., and I. Herskowitz. 1988. STE2 protein of Saccharomyces kluyveri is a member of the rhodopsin/beta-adrenergic receptor family and is responsible for recognition of the peptide ligand α-factor. Proc. Natl. Acad. Sci. USA. 85:3855-3859.
28. Marsh, L., A.M. Neiman, and I. Herskowitz. 1991. Signal transduction during pheromone response in yeast. Annu. Rev. Cell Biol. 7:699-728.
29. McCaffrey, G., F. Clay, K. Kelsey, and G.F. Sprague, Jr. 1987. Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 7:2680-2690.
30. McGrath, J.P., and A. Varshavsky. 1989. The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein. Nature (Lond.). 340:400-404.
31. Michaelis, S. 1993. STE6, the yeast a-factor transporter. Semin. Cell Biol. 4: 17-27.
32. Michaelis, S., and I. Herskowitz. 1988. The a-factor pheromone of Saccharomyces cerevisiae is essential for mating. Mol. Cell. Biol. 8:1309-1318.
33. Rose, M.D., P. Novick, J.H. Thomas, D. Botstein, and G.R. Fink. 1987. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene (Amst.). 60:237-243.
34. Rose, M.D., F. Winston, and P. Hieter. 1990. Methods in Yeast Genetics: A laboratory Course Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 198 pp.
35. Rothstein, R. 1991. Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194:281-301.
36. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning. A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
37. Segall, J.E. 1993. Polarization of yeast cells in spatial gradients of a mating factor. Proc. Natl. Acad. Sci. USA. 90:8332-8336.
38. Sen, M., and L. Marsh. 1994. Noncontiguous domains of the a-factor receptor of yeasts confer ligand specificity. J. Biol. Chem. 269:968-973.
39. Sprague, G.F., Jr. 1991. Assay of yeast mating reaction. Methods Enzymol. 194:77-93.
40. Sprague, G.F., Jr., and J.W. Thorner. 1992. Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae. In The Molecular and Cellular Biology of the Yeast Saccharomyces. Vol. 2. Gene Expression. E.W. Jones, J.R. Pringle, and J.R. Broach, editors. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 657-744.
41. Strazdis, J.R., and V.L. MacKay. 1982. Reproducible and rapid methods for the isolation and assay of a-factor, a yeast mating hormone. J. Bacteriol. 151:1153-1161.
42. Tomeo, M.E., G. Fenner, S.R. Tove, and L.W. Parks. 1992. Effect of sterol alterations on conjugation in Saccharomyces cerevisiae. Yeast 8:1015-1024.
43. Trueheart, J., J.D. Boeke, and G.R. Fink. 1987. Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol. Cell. Biol. 7:2316-2328.
44. Wilson, K.L., and I. Herskowitz. 1984. Negative regulation of STE6 gene expression by the α2 product of Saccharomyces cerevisiae. Mol. Cell. Biol. 4:2420-2427.