Dynamic and electrostatic effects in enzymatic processes. An analysis of the nucleophilic substitution reaction in haloalkane dehalogenase

Journal of the American Chemical Society

Volumn 127, Issue 6, 2005, Pages 1946-1957

  Soriano, Alejandro ^a   Silla, Estanislao ^a   Tuñón, Iñaki ^a   Ruiz López, Manuel F ^b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b NANCY UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL REACTIONS; ELECTROSTATICS; HYDROGEN BONDS; NEGATIVE IONS; SOLUTIONS; SUBSTRATES;

ENZYMATIC PROCESSES; NUCLEOPHILIC DISPLACEMENT; RARE EVENT TRAJECTORIES; TRANSMISSION COEFFICIENT;

ENZYMES;

1,2 DICHLOROETHANE; BACTERIAL ENZYME; CARBOXYLIC ACID DERIVATIVE; CHLORIDE ION; HALOALKANE DEHALOGENASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVE SITE; ENZYME KINETICS; HYDROGEN BOND; MOLECULAR INTERACTION; SUBSTITUTION REACTION; XANTHOBACTER;

CHLORIDES; ELECTROSTATICS; ETHYLENE DICHLORIDES; HYDROGEN BONDING; HYDROLASES; KINETICS; MODELS, MOLECULAR; QUANTUM THEORY; XANTHOBACTER;

EID: 13644269269     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja046553h     Document Type: Article

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