Effects of tunicamycin, mannosamine, and other inhibitors of glycoprotein processing on skeletal alkaline phosphatase in human osteoblast-like cells

Calcified Tissue International

Volumn 76, Issue 1, 2005, Pages 63-74

  Farley, J R ^a   Magnusson, P ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alkaline phosphatase; Osteoblast

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; GLYCOPROTEIN; MANNOSAMINE; OLIGOSACCHARIDE; PROTEIN INHIBITOR; SIALIC ACID; TUNICAMYCIN; WHEAT GERM AGGLUTININ;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CARBOHYDRATE SYNTHESIS; CELL ADHESION; CELL MEMBRANE; CELLULAR DISTRIBUTION; CHEMICAL REACTION KINETICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; OSTEOBLAST; OSTEOSARCOMA CELL; PHASE SEPARATION; PRECIPITATION; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; SOLUBILITY; TEMPERATURE DEPENDENCE; TIME; VELOCITY;

ALKALINE PHOSPHATASE; ANTI-BACTERIAL AGENTS; APOPTOSIS; BONE AND BONES; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSYLPHOSPHATIDYLINOSITOLS; HEXOSAMINES; HUMANS; KINETICS; MEMBRANE GLYCOPROTEINS; OSTEOBLASTS; OSTEOSARCOMA; PHENANTHROLINES; TUMOR CELLS, CULTURED; TUNICAMYCIN;

EID: 13644267779     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-004-0023-2     Document Type: Article

References (48)

1. McComb RB, Bowers GN Jr, Posen S (1979) Alkaline phosphatase. Plenum Press, New York
2. Ferguson MA, Williams AF (1988) Cell surface anchoring of proteins via glycosyl-phosphatidyl-inositol structures. Annual Rev Biochem 57:285-320
3. Millan JL, Fishman WH (1995) Biology of human alkaline phosphatases with special reference to cancer. Crit Rev Clin Lab Sci 32:1-39
4. Fedde KN, Lane CC, Whyte MP (1988) Alkaline phosphatase is an ectoenzyme that acts on micromolar concentrations of natural substrates at physiologic pH in human osteosarcoma cells. Arch Biochem Biophys 263:400-409
5. Hooper NM (1997) Glycosyl-phosphatidylinositol anchored membrane enzymes. Clin Chim Acta 266:3-12
6. Fallon MD, Whyte MP, Teitelbaum SL (1980) Stereospecific inhibition of alkaline phosphatase by L-tetramisole prevents in vitro cartilage calcification. Lab Invest 43:489-494
7. Yoon K, Golub E, Rodan GA (1989) Alkaline phosphatase cDNA transfected cells promote calcium and phosphorous deposition. Connect Tissue Res 22:17-25
8. Weiss MV, Cole DEC, Ray K, Whyte MP, Lafferty MA, Mulivor RA, Harris H (1988) A missense mutation in the human liver/bone/kidney alkaline phosphatase gene causing a lethal form of hypophosphatasia. Proc Natl Acad Sci USA 85:7666-7669
9. Fedde K, Blair L, Silverstein J, Coburn S, Ryan L, Weinstein R, Waymire K, Narisawa S, Millan J, MacGregor G, Whyte M (1999) Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. J Bone Miner Res 14:2015-2026
10. Wennberg C, Hessle L, Lundberg P, Mauro S, Narisawa S, Lerner UH, Millan JL (2000) Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice. J Bone Miner Res 15:1879-1888
11. Johnson KA, Hessle L, Vaingankar S, Wennberg C, Mauro S, Narisawa S, Goding JW, Sano K, Millan JL, Terkeltaub R (2000) Osteoblast tissue-nonspecific ALP antagonizes and regulated PC-1. Am J Physiol Reg Integr Comp Physiol 279:R1365-R1377
12. Hessle L, Johnson K, Anderson H, Narisawa S, Sali A, Goding J, Terkeltaub R, Milan JL (2002) Tissue-non-specific ALP and plasma membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. PNAS 99:9445-9449
13. Lauffenburger T, Olah AJ, Dambacher J, Guncaga J, Lentner C, Haas H (1977) Bone remodeling and calcium metabolism: a correlated histomorphometric, calcium kinetic, and biochemical study in patients with osteoporosis and Paget's disease. Metabolism 26:589-597
14. Van Straalen JP, Sanders E, Prummel MF, Sanders GTB (1991) Bone-alkaline phosphatase as indicator of bone formation. Clin Chim Acta 201:27-34
15. Fedde KN (1992) Human osteosarcoma cells spontaneously release matrix-vesicle-like structures with the capacity to mineralize. Bone Miner 17:145-151
16. Farley JR, Stilt-Coffing B (2001) Apoptosis may determine the release of skeletal alkaline phosphatase activity from human osteobalst-line cells. Calcif Tiss Int 68:43-52
17. Jilka R, Weinstein R, Bellido T, Parfitt A, Manolagas S (1998) Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J Bone Miner Res 13:793-802
18. Jilka R, Weinstein R, Bellido T, Roberson P, Parfitt A, Manolagas S (1999) Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J Clin Invest 104:439-446
19. Anderson HC (1995) Molecular biology of matrix vesicles. Clin Orthop 314:266-280
20. Huang K-S, Li S, Low MG (1991) Glycosylphosphatidylinositol-specific phospholipase D Methods. Enzymol 197:567-575
21. Hamilton BA, McPhee JL, Hawrylak K, Stinson RA (1989) Alkaline phosphatase releasine activity in human tissues. Clin Chim Acta 186:249-254
22. Magnusson P, Farley JR (2002) Differences in sialic acid residues among bone alkaline phosphatase isoforms: a physical, biochemical, and immunological characterization. Calcif Tissue Int 71:508-518
23. Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, Harris H (1986) Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase. Proc Natl Acad Sci USA 83:7182-7186
24. Nosjean O, Koyama I, Goseki M, Roux B, Komoda T (1997) Human tissue-non-specific alkaline phosphatases: sugar-moiety-induced enzymic and antigenic modulations and genetic aspects. Biochem J 321 (part 2) 297-303
25. Varki A, Cummings R, Esko J, Freeze H, Hart G, Marth J, editors (1999) Essentials of glycobiology. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
26. Elbein AD (1987) Inhibitors of the biosynthesis and processing of N-linked oligosaccharide chains. Ann Rev Biochem 56:497-534
27. Legler G (1973) Active site directed inhibitors and mechanism of action of glycosidases. Mol Cell Biochem 2:31-38
28. Wainwright LJ, Field MC (1997) Quality control of glycosylphosphatidylinositol anchor attachment in mammalian cells: a biochemical study. Biochem J 321:655-664
29. Udenfriend S, Kodukula K (1995) How glycosyl-phosphatidylinositol- anchored membrane proteins are made. Ann Rev Biochem 64:563-591
30. Spurway TD, Dalley JA, High S, Bulleid NJ (2001) Early events in glycosylphosphatidyl-inositol anchor addition. J Biol Chem 276:15975-15982
31. Sevlever D, Rosenberry TL (1993) Mannosamine inhibits the synthesis of putative glycosinositol phospholipid anchor precursors in mammalian cells without incorporating into an accumulated intermediate. J Biol Chem 268:10938-10945
32. Pan YT, Kamitani T, Bhuvaneswaran C, Hallaq Y, Warren CD, Yeh ET, Elbein AD (1992) Inhibition of glycosylphosphatidylinositol anchor formation by mannosamine. J Biol Chem 267:21250-21255
33. Mann KJ, Svlever D (2001) 1,10-Phenanthroline inhibits glycosylphosphatidylinositol anchoring by preventing phosphoethanolamine addition to glycosylphosphatidylinositol anchor precursors. Biochemistry 40:1205-1213
34. Bordier C (1981) Phase separation of integral membrane proteins in Triton X-114 solution. J Biol Chem 256:1604-1607
35. Anh DJ, Dimai HP, Hall SL, Farley JR (1998) Skeletal alkaline phosphatase activity is primarily released form human osteoblasts in an insoluble form and the net release is inhibited by calcium and skeletal growth factors. Calcif Tissue Int 62:332-340
36. Farley JR, Hall SL, Herring S, Tarbaux NM, Matsuyama T, Wergedal J (1991) Skeletal alkaline phosphatase specific activity is an index of the osteoblastic phenotype in subpopulations of the human osteosarcoma cell line SaOS-2. Metabolism 40:664-671
37. Murray E, Provvendini D, Curran D, Catherwood B, Sussman H, Manolagas S (1987) Characterization of a human osteoblastic osteosarcoma cell line (SaOS-2) with high bone alkaline phosphatase activity. J Bone Miner Res 2:231-238
38. Farley JR, Kyeyune-Nyombi E, Tarbaux NM, Hall SL, Strong DD (1989) Alkaline phosphatase activity from human osteosarcoma cell line SaOS-2: an isoenzyme standard for quantifying skeletal alkaline phosphatase activity in serum. Clin Chem 35:223-229
39. Bradford MM (1976) A rapid and sensitive method for quantitation of microgram amounts of protein using the principle of protein-dye binding. Anal Biochem 72:248-255
40. 3[H]-thymidine incorporation in embryonic chick calvarial cell cultures is dependent on the presence of a bone cell mitogen, sensitive to changes in the phosphate concentration, and modulated by systemic skeletal effectors. Metabolism 37:988-995
41. 3[H]-thymidine incorporation and alkaline phosphatase activity in human osteoblast-line cells. Calcif Tissue Int 48:297-301
42. Farley JR, Tarbaux NM, Hall SL, Linkhart TA, Baylink DJ (1988) The anti-bone-resorptive agent calcitonin also acts in vitro to directly increase bone formation and bone cell proliferation. Endocrinology 123:159-167
43. Anh DJ, Eden A, Farley JR (2001) Quantitation of soluble and skeletal alkaline phosphatase, and insoluble alkaline phosphatase anchor-hydrolase activities in human serum. Clin Chim Acta 311:137-148
44. Farley JR (1995) Phosphate regulates the stability of skeletal alkaline phosphatase activity in human osteosarcoma (SaOS-2) cells without equivalent effects on the level of skeletal alkaline phosphatase immunoreactive protein. Calcif Tissue Int 57:371-378
45. Magnusson P, Lofman O, Larsson L (1993) Methodological aspects on separation and reaction conditions of bone and liver alkaline phosphatase isoform analysis by high-performance liquid chromatography. Anal Biochem 211:156-163
46. Magnusson P, Hager A, Larsson L (1995) Serum osteocalcin and bone and liver alkaline phosphatase isoforms in healthy children and adolescents. Pediatr Res 38:955-961
47. Magnusson P, Lofman O, Toss G, Larsson L (1995) Determination of bone alkaline phosphatase isoforms in serum by a new high-performance liquid chromatography assay in patients with metabolic bone disease. Acta Ortho Scand 66 (Suppl 266): 203-204
48. Magnusson P, Sharp CA, Magnusson M, Risteli J, Davie MWJ, Larsson L (2001) Effect of chronic renal failure on bone turnover and bone alkaline phosphatase isoforms. Kidney Int 60:257-165