Subunit-specific contribution to agonist binding and channel gating revealed by inherited mutation in muscle acetylcholine receptor M3-M4 linker

Brain

Volumn 128, Issue 2, 2005, Pages 345-355

  Shen, Xin Ming ^a   Ohno, Kinji ^a   Sine, Steven M ^a   Engel, Andrew G ^a  

^a MAYO CLINIC   (United States)

Author keywords

Acetylcholine receptor; Congenital myasthenic syndrome; M3 M4 loop; Mutagenesis; Single channel patch clamp recordings

Indexed keywords

ASPARAGINE; ASPARTIC ACID; CHOLINERGIC RECEPTOR; RECEPTOR SUBUNIT;

ADULT; ALLELE; ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CASE REPORT; CELL LINE; CHANNEL GATING; CONGENITAL DISORDER; CONTROLLED STUDY; CYTOPLASM; DELETION MUTANT; DISSOCIATION; EATON LAMBERT SYNDROME; FEMALE; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; INHERITANCE; KINETICS; NERVE ENDING; NEUROMUSCULAR TRANSMISSION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SCHOOL CHILD; SEQUENCE ANALYSIS;

ADULT; AMINO ACID SEQUENCE; CELL LINE; CHILD; DNA MUTATIONAL ANALYSIS; EVOKED POTENTIALS, MOTOR; FACIES; FEMALE; HUMANS; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; MOTOR ENDPLATE; MUSCLE, SKELETAL; MUTATION; MYASTHENIC SYNDROMES, CONGENITAL; PATCH-CLAMP TECHNIQUES; RECEPTORS, CHOLINERGIC; SPECIES SPECIFICITY;

EID: 13544266220     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/awh364     Document Type: Article

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