Serotonergic paradoxes of autism replicated in a simple mathematical model

Medical Hypotheses

Volumn 64, Issue 4, 2005, Pages 742-750

  Janušonis, Skirmantas ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; SEROTONIN TRANSPORTER;

ARTICLE; AUTISM; DISEASE ASSOCIATION; ENTEROCHROMAFFIN CELL; GENETIC POLYMORPHISM; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOLECULAR MECHANICS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; SEROTONIN BLOOD LEVEL; SEROTONIN RELEASE; SEROTONIN UPTAKE; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 13444310798     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.09.020     Document Type: Article

References (54)

1. F.R. Volkmar, C. Lord, A. Bailey, R.T. Schultz, and A. Klin Autism and pervasive developmental disorders J Child Psychol Psychiat 45 2004 135 170
2. R.J. Schain, and D.X. Freedman Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children J Pediatr 58 1961 315 320
3. H.G. Hanley, S.M. Stahl, and D.X. Freedman Hyperserotonemia and amine metabolites in autistic and retarded children Arch Gen Psychiat 34 1977 521 531
4. G.M. Anderson, D.X. Freedman, and D.J. Cohen Whole blood serotonin in autistic and normal subjects J Child Psychol Psychiat 28 1987 885 900
5. G.M. Anderson, W.C. Horne, D. Chatterjee, and D.J. Cohen The hyperserotonemia of autism Ann NY Acad Sci 600 1990 331 340
6. E.H. Cook Jr. Brief report: pathophysiology of autism: neurochemistry J Autism Dev Disord 26 1996 221 225
7. G.M. Anderson Genetics of childhood disorders: XLV. Autism, part 4: serotonin in autism J Am Acad Child Adolesc Psychiat 41 2002 1513 1516
8. D.J. Walther, J.U. Peter, and S. Bashammakh Synthesis of serotonin by a second tryptophan hydroxylase isoform Science 299 2003 76
9. R.B. Minderaa, G.M. Anderson, F.R. Volkmar, G.W. Akkerhuis, and D.J. Cohen Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects Biol Psychiat 22 1987 933 940
10. M. Narayan, S. Srinath, G.M. Anderson, and D.B. Meundi Cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid in autism Biol Psychiat 33 1993 630 635
11. E.J. Mulder, G.M. Anderson, and I.P. Kema Platelet serotonin levels in pervasive developmental disorders and mental retardation: diagnostic group differences, within-group distribution, and behavioral correlates J Am Acad Child Adolesc Psychiat 43 2004 491 499
12. A.M. Coutinho, G. Oliveira, and T. Morgadinho Variants of the serotonin transporter gene (SLC6A4) significantly contribute to hyperserotonemia in autism Mol Psychiat 9 2004 264 271
13. E.H. Cook Jr., R. Courchesne, and C. Lord Evidence of linkage between the serotonin transporter and autistic disorder Mol Psychiat 2 1997 247 250
14. G.M. Anderson, L. Gutknecht, and D.J. Cohen Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia Mol Psychiat 7 2002 831 836
15. C. Betancur, M. Corbex, and C. Spielewoy Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder Mol Psychiat 7 2002 67 71
16. A.M. Persico, T. Pascucci, and S. Puglisi-Allegra Serotonin transporter gene promoter variants do not explain the hyperserotoninemia in autistic children Mol Psychiat 7 2002 795 800
17. O.V. Mortensen, A.S. Kristensen, G. Rudnick, and O. Wiborg Molecular cloning, expression and characterization of a bovine serotonin transporter Brain Res Mol Brain Res 71 1999 120 126
18. K.J. Lin, X.X. Ye, and T.C. Yen Biodistribution study of [(123)I] ADAM in mice: correlation with whole body autoradiography Nucl Med Biol 29 2002 643 650
19. S. Ramamoorthy, A.L. Bauman, and K.R. Moore Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization Proc Natl Acad Sci USA 90 1993 2542 2546
20. G.M. Anderson, J.M. Stevenson, and D.J. Cohen Steady-state model for plasma free and platelet serotonin in man Life Sci 41 1987 1777 1785
21. E.E. Billett Monoamine oxidase (MAO) in human peripheral tissues Neurotoxicology 25 2004 139 148
22. H. Schworer, and G. Ramadori Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro Naunyn Schmiedebergs Arch Pharmacol 357 1998 548 552
23. K. Racke, A. Reimann, H. Schworer, and H. Kilbinger Regulation of 5-HT release from enterochromaffin cells Behav Brain Res 73 1996 83 87
24. A.L. Kirchgessner, M.T. Liu, J.R. Raymond, and M.D. Gershon Identification of cells that express 5-hydroxytryptamine1A receptors in the nervous systems of the bowel and pancreas J Comp Neurol 364 1996 439 455
25. N.M. Barnes, and T. Sharp A review of central 5-HT receptors and their function Neuropharmacology 38 1999 1083 1152
26. E. Bagdy, S. Solyom, and L.G. Harsing Jr. Feedback stimulation of somatodendritic serotonin release: a 5-HT3 receptor-mediated effect in the raphe nuclei of the rat Brain Res Bull 45 1998 203 208
27. A. Adell, P. Celada, M.T. Abellan, and F. Artigas Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei Brain Res Brain Res Rev 39 2002 154 180
28. P.L. Yu, M. Fujimura, N. Hayashi, T. Nakamura, and M. Fujimiya Mechanisms in regulating the release of serotonin from the perfused rat stomach Am J Physiol Gastrointest Liver Physiol 280 2001 G1099 G1105
29. O. Beck, N.H. Wallen, A. Broijersen, P.T. Larsson, and P. Hjemdahl On the accurate determination of serotonin in human plasma Biochem Biophys Res Commun 196 1993 260 266
30. E.F. Marshall, and M. Leitch Plasma serotonin J Chromatogr B Biomed Appl 655 1994 167 168
31. G.M. Anderson, F.C. Feibel, and D.J. Cohen Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate Life Sci 40 1987 1063 1070
32. I. Hervas, and F. Artigas Effect of fluoxetine on extracellular 5-hydroxytryptamine in rat brain. Role of 5-HT autoreceptors Eur J Pharmacol 358 1998 9 18
33. R.E. Heuring, and S.J. Peroutka Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes J Neurosci 7 1987 894 903
34. R.G. Johnson, C.M. Severin, and R.A. Rabin Serotonergic binding in the rat dorsal raphe nucleus: critical role of MAO inhibition J Pharmacol Toxicol Meth 36 1996 81 85
35. M.N. Subhash, B.N. Srinivas, K.Y. Vinod, and S. Jagadeesh Modulation of 5-HT1A receptor mediated response by fluoxetine in rat brain J Neural Transm 107 2000 377 387
36. Anderson GM, Barr CS, Lindell S, Durham AC, Shifrovich I, Higley JD. Time course of SSRI (Sertraline) effects on central and peripheral serotonin neurochemistry in the rhesus monkey. Psychopharmacology [in press]
37. J.P. Ternaux, J. Gonella, C. Legay, M. Faudon, M.C. Barrit, and F. Hery 5-HT metabolism in the intestinal wall of the rabbit J Physiol (Paris) 77 1981 319 326
38. D.P. Thomas, and J.R. Vane 5-Hydroxytryptamine in the circulation of the dog Nature 216 1967 335 338
39. A.S. Chang, S.M. Chang, D.M. Starnes, S. Schroeter, A.L. Bauman, and R.D. Blakely Cloning and expression of the mouse serotonin transporter Brain Res Mol Brain Res 43 1996 185 192
40. R.D. Blakely Physiological genomics of antidepressant targets: keeping the periphery in mind J Neurosci 21 2001 8319 8323
41. I.L. Cohen, X. Liu, and C. Schutz Association of autism severity with a monoamine oxidase A functional polymorphism Clin Genet 64 2003 190 197
42. N. Yirmiya, T. Pilowsky, S. Tidhar, L. Nemanov, L. Altmark, and R.P. Ebstein Family-based and population study of a functional promoter-region monoamine oxidase A polymorphism in autism: possible association with IQ Am J Med Genet 114 2002 284 287
43. J.M. Launay, P. Ferrari, and M. Haimart Serotonin metabolism and other biochemical parameters in infantile autism. A controlled study of 22 autistic children Neuropsychobiology 20 1988 1 11
44. L. Tecott, S. Shtrom, and D. Julius Expression of a serotonin-gated ion channel in embryonic neural and nonneural tissues Mol Cell Neurosci 6 1995 43 55
45. O. Bar-Peled, R. Gross-Isseroff, H. Ben Hur, I. Hoskins, Y. Groner, and A. Biegon Fetal human brain exhibits a prenatal peak in the density of serotonin 5-HT1A receptors Neurosci Lett 127 1991 173 176
46. E. del Olmo, A. Diaz, M. Guirao-Pineyro, C. del Arco, J. Pascual, and A. Pazos Transient localization of 5-HT1A receptors in human cerebellum during development Neurosci Lett 166 1994 149 152
47. D.A. Johnson, S.E. Gartside, and C.D. Ingram 5-HT1A receptor-mediated autoinhibition does not function at physiological firing rates: evidence from in vitro electrophysiological studies in the rat dorsal raphe nucleus Neuropharmacology 43 2002 959 965
48. A.R. Ase, T.A. Reader, R. Hen, M. Riad, and L. Descarries Altered serotonin and dopamine metabolism in the CNS of serotonin 5-HT(1A) or 5-HT(1B) receptor knockout mice J Neurochem 75 2000 2415 2426
49. D.C. Chugani Role of altered brain serotonin mechanisms in autism Mol Psychiat 7 Suppl 2 2002 S16 S17
50. P.J. Tyson, K.H. Roberts, and A.M. Mortimer Are the cognitive effects of atypical antipsychotics influenced by their affinity to 5HT-2A receptors? Int J Neurosci 114 2004 593 611
51. E.H. Cook, and B.L. Leventhal The serotonin system in autism Curr Opin Pediatr 8 1996 348 354
52. J.K. Buitelaar, and S.H. Willemsen-Swinkels Autism: current theories regarding its pathogenesis and implications for rational pharmacotherapy Pediatr Drugs 2 2000 67 81
53. Goldberg J, Szatmari P, Zwaigenbaum L. Diminished serotonin receptor function: a potential endophenotype of autism. International Meeting for Autism Research 2004, Abstract S3.2.3
54. J. Gelernter, H. Kranzler, and J.F. Cubells Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects Hum Genet 101 1997 243 246