Does long-term compressive loading on the intervertebral disc cause degeneration?

Spine

Volumn 25, Issue 23, 2000, Pages 2993-3004

  Hutton, William C ^a,b   Ganey, Timothy M ^a   Elmer, William A ^b   Kozlowska, Eva ^a   Ugbo, John L ^a   Doh, Eun Sig ^c   Whitesides Jr , Thomas E ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c Yeungnam University College of Medicine   (South Korea)

Author keywords

Collagen; Compression; Degeneration; Intervertebral disc; Proteoglycan

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; PROTEOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CONTROLLED STUDY; DOG; INTERVERTEBRAL DISK DEGENERATION; LUMBAR SPINE; MALE; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; SPINAL CORD COMPRESSION;

ANIMALS; COLLAGEN; COMPRESSIVE STRENGTH; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MALE; PROTEOGLYCANS; TIME FACTORS; WEIGHT-BEARING;

EID: 0034405705     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-200012010-00006     Document Type: Article

References (29)

1. Similarities in degenerative findings on magnetic resonance images of the lumbar spines of identical twins
2. Determinants of lumbar disc degeneration A study relating lifetime exposures and magnetic resonance imaging findings in identical twins
3. Effects of hydrostatic pressure on matrix synthesis and matrix metalloproteinase production in the human lumbar intervertebral disc
4. Risk factors for low back pare and sciatica
5. The Munkfors mvestigation
6. The effect of compressive force applied to the intervertebral disc in vivo A study of proteoglycans and collagen
7. The effect of hydrostatic pressure on intervertebral disc metabolism
8. Do the intervertebral discs respond to different levels of hydrostatic pressure?
9. Compression-induced changes in intervertebral disc properties in a rat tail model
10. Effects of hydrostatic pressure on matrix synthesis in different regions of the intervertebral disc
11. The large proteoglycans of the human intervertebral disc Changes in their biosynthesis and structure with age, topography and pathology
12. Keratan sulfate as a potential biomarker of loading of the intervertebral disc
13. Rheumatism in coal miners Part III: Occupational factors
14. Volvo Award Winner in Biomechanical Studies. Compression-induced degeneration of the intervertebral disc: An in vivo mouse model and finite-element study
15. Proteoglycans of the intervertebral disc
16. Immunohistologic markers for age-related changes of human lumbar intervertebral discs
17. Physical activity and the strength of the lumbar spine
18. Enzyme-linked immunoassay (ELISA) for connective tissue components
19. Physiochemical characterization and molecular organization of the collagen A and B chains
20. Radiographically detectable degenerative changes of the lumbar spine among concrete reinforcement workers and house painters
21. Low back pain in industry. A position paper
22. Felling work, low back pain, and osteoarthritis
23. Berufliche belastungsschaden der wirbelsaule
24. Mechanisms and genes in cellular suicide
25. Lumbar spinal pathology in cadaveric material in relation to history of back pain, occupation, and physical loading
26. Lifetime exercise and disk degeneration: An MRI study of monozygotic twins
27. Iatrogenic polymorphisms of the vitamin D receptor gene associated with intervertebral disc degeneration
28. Spine update: The influence of occupation on lumbar degeneration
29. New in vivo measurements of pressures in the intervertebral disc in daily life