Low-dose terlipressin for hemodynamic support in sepsis and systemic inflammatory response syndrome: Art for (he)art's sake or state of the art?

Critical Care Medicine

Volumn 33, Issue 2, 2005, Pages 455-457

  Westphal, Martin ^a   Traber, Daniel L ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Endotoxemia; Hemodynamics; Microcirculation; Sepsis; Shock; Terlipressin; Vasopressin

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ARGIPRESSIN; BETA ADRENERGIC RECEPTOR; CALCIUM ION; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; LACTIC ACID; NITRIC OXIDE; NORADRENALIN; PHOSPHOLIPASE C; POTASSIUM CHANNEL; TERLIPRESSIN; VASOPRESSIN; VASOPRESSIN DERIVATIVE; VASOPRESSIN RECEPTOR;

BLOOD PRESSURE; CALCIUM CELL LEVEL; EDITORIAL; ENDOTOXEMIA; HEART HEMODYNAMICS; HEART INDEX; HUMAN; HYPERLACTATEMIA; HYPOTENSION; LIVER BLOOD FLOW; LOW DRUG DOSE; LUNG CIRCULATION; NONHUMAN; PRIORITY JOURNAL; RESUSCITATION; SEPSIS; SPLANCHNIC BLOOD FLOW; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; VASCULAR DISEASE; VASOCONSTRICTION;

ANIMALS; HEMODYNAMIC PROCESSES; HUMANS; LIVER CIRCULATION; LYSINE VASOPRESSIN; SEPSIS; SPLANCHNIC CIRCULATION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; VASOCONSTRICTOR AGENTS;

EID: 13444281897     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000153526.24976.83     Document Type: Editorial

References (31)

1. Nilsson G, Lindblom P, Ohlin M, et al: Pharmacokinetics of terlipressin after single i. v. doses to healthy volunteers. Drugs Exp Clin Res 1990; 16:307-314
2. +-channel activities of cultured smooth muscle cells from porcine coronary artery. Am J Physiol 1992; 32:H491-H496
3. Bucher M, Hobbhahn J, Taeger K, et al: Cytokine-mediated downregulation of vasopressin V(1A) receptors durng acute endotoxemia in rats. Am J Physiol Regul Integr Comp Physiol 2002; 282:R979-R984
4. Landry DW, Levin HR, Gallant EM, et al: Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation 1997; 95:1122-1125
5. Landry DW, Levin HR, Gallant EM, et al: Vasopressin pressor hypersensitivity in vasodilatory septic shock. Crit Care Med 1997;25:1279-1282
6. Patel BM, Chittok DR, Russell JA, et al: Beneficial effects of short-term vasopressin infusion during severe septic shock. Anesthesiology 2002; 96:576-582
7. O'Brien A, Clapp L, Singer M: Terlipressin for epinephrine-resistant septic shock. Lancet 2002; 359:1209-1210
8. Dunser AW, Mayer AJ, Ulmer H, et al: Arginine vasopressin in advanced vasodilatory shock: A prospective randomized, controlled study. Circulation 2003; 107:2313-2319
9. Medel J, Boccara G, Van de Steen E, et al: Terlipressin for treating intraoperative hypotension: Can it unmask myocardial ischemia? Anesth Analg 2001; 93:53-55
10. Scharte M, Meyer J, Van Aken H, et al: Hemodynamic effects of terlipressin (a synthetic analog of vasopressin) in healthy and endotoxemic sheep. Crit Care Med 2001; 29:1756-1760
11. Ioannou G, Doust J, Rockey DC: Terlipressin for acute esophageal variceal hemorrhage. Cochrane Database Syst Rev 2003; CD002147
12. Morelli A, Rocco M, Conti G, et al: Effects of terlipressin on systemic and regional hemodynamics in catecholamine-treated hyperkinetic shock. Intensive Care Med 2004; 30:597-604
13. Westphal M, Ertmer C, Van Aken H, et al: Terlipressin in patients with septic shock: Friend or foe? Intensive Care Med 2004; 30:992
14. Westphal M, Stubbe H, Sielenkämper AW, et al: Terlipressin dose response in healthy and endotoxaemic sheep: Impact on cardiopulmonary performance and global oxygen transport. Intensive Care Med 2003; 29: 301-308
15. Traber DL: Animal models: The sheep. Crit Care Med 2000; 28:591-592
16. Asfar P: Terlipressin in chronic hyperdynamic endotoxic shock: Is it safe? Intensive Care Med 2003; 29:154-155
17. Ince C, Sinaasappel M: Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 1999; 27:1369-1377
18. Asfar P, Hauser B, Iványi Z, et al: Low-dose terlipressin during long-term hyperdynamic porcine endotoxemia: Effects on hepatosplanchnic perfusion, oxygen exchange, and metabolism. Crit Care Med 2005; 33:373-380
19. Cooper KE, Naylor AM, Veale WL: Evidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep. J Physiol 1979; 295:33-45
20. Segarra G, Medina P, Domenech C, et al: Role of vasopressin on adrenergic neurotransmission in human penile blood vessels. J Pharmacol Exp Ther 1998; 286:1315-1320
21. 2 delivery. Am J Physiol Heart Circ Physiol 2000; 279:H1922-H1930
22. Traber DL: ATP and sepsis. Crit Care Med 1999; 27:865-866
23. Asfar P, Pierrot M, Veal N, et al: Low-dose terlipressin improves systemic and splanchnic hemodynamics in fluid-challenged endotoxic rats. Crit Care Med 2003; 231:215-220
24. Dellinger RP, Carlet JM, Masur H, et al: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873
25. Westphal M, Freise H, Kehrel B, et al: Arginine vasopressin compromises gut mucosal microcirculation in septic rats. Crit Care Med 2004; 32:194-200
26. Klinzing S, Simon M, Reinhart K, et al: High-dose vasopressin is not superior to norepinephrine in septic shock. Crit Care Med 2003; 31:2646-2650
27. Sun Q, Dimopoulos G, Nguyen DN, et al: Low-dose vasopressin in the treatment of septic shock in sheep. Am J Respir Crit Care Med 2003; 168:481-487
28. Westphal M, Traber LD, Enkhbaatar P, et al: Chronic inhibition of nitric oxide synthase and increased vascular responsiveness to vasopressin: What is the link? J Hepatol 2004; 41:160-170
29. James JH, Luchette FA, McCarter FD, et al: Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet 1999; 354:505-508
30. Dünser MW, Mayr AJ, Tur A, et al: Ischemic skin lesions as a complication of continuous vasopressin infusion in catecholamine-resistant vasodilatory shock: Incidence and risk factors. Crit Care Med 2003; 31:1394-1398
31. Westphal M, Ertmer C, Van Aken H, et al: Pressure or flow? Anaesth Intensive Care 2004; 32:437-438