Animal models: The sheep

Critical Care Medicine

Volumn 28, Issue 2, 2000, Pages 591-592

  Traber, Daniel L ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Cardiovascular; Endotoxin; Heart; Pulmonary; Sepsis

Indexed keywords

ENDOTOXIN; HEMOGLOBIN; PIRIDOXILATE; POLYOXYETHYLENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; CLINICAL TRIAL; EDITORIAL; HEART FUNCTION; HUMAN; NONHUMAN; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; SHEEP; VASODILATATION;

EID: 0034100173     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200002000-00061     Document Type: Editorial

References (18)

1. 1. Pittet J-F, Pastor CM, Morel DR: Spontaneous high systemic oxygen delivery increases survival rate in awake sheep during sustained endotoxemia. Crit Care Med 2000; 28: 496-503
2. 2. Morel DR, Lacroix JS, Hemsen A, et al: Increased plasma and pulmonary lymph levels of endothelin during endotoxin shock. Eur J Pharmacol 1989; 167:427-428
3. 3. Bone HG, Waurick R, Van Aken H, et al: Comparison of the haemodynamic effects of nitric oxide synthase inhibition and nitric oxide scavenging in endotoxaemic sheep. Intensive Care Med 1998; 24:48-54
4. 4. Spath JA Jr, Sloane PJ, Gee MH, et al: Loss of endothelium-dependent vasodilation in the pulmonary vessels of sheep after prolonged endotoxin. J Appl Physiol 1994; 76:361-369
5. 5. Pollard V, Prough DS, Deyo DJ, et al: Cerebral blood flow during experimental endotoxemia in volunteers. Crit Care Med 1997; 25: 1700-1706
6. 6. Perkowski SZ, Sloane PJ, Spath JA, et al: TNF-alpha and the pathophysiology of endotoxin-induced acute respiratory failure in sheep. J Appl Physiol 1996; 80:564-573
7. 7. Booke M, Hinder F, McGuire R, et al: Nitric oxide synthase inhibition versus norepinephrine for the treatment of hyperdynamic sepsis in sheep. Crit Care Med 1996; 24:835-844
8. 8. Bone HC, Schenarts PJ, Booke M, et al: Oxalated pyridoxilated hemoglobin polyoxyethylene conjugate normalizes the hyperdynamic circulation in septic sheep. Crit Care Med 1997; 25:1010-1018
9. 9. Sloane PJ, Elsasser TH, Spath JA, et al: Plasma tumor necrosis factor-alpha during long-term endotoxemia in awake sheep. J Appl Physiol 1992; 73:1831-1837
10. 10. Bone HG, Goyert SM, Traber DL: Cytokine mRNA expression with continuous infusion of endotoxin. In: Shock from Molecular and Cellular Level to Whole Body. Okada K, Ogata H (Ed). Amsterdam, Elsevier, 1996, pp 149-160
11. 11. Nakasawa H, Noda H, Traber LD, et al: Endotoxin induced elevation of lung fluid flux is not caused by increased permeability to protein but for small molecules. Abstr. Circ Shock 1992; 37:39
12. 12. Fischer SR, Bone HG, Powell WC, et al: Pyridoxilated hemoglobin polyoxyethylene conjugate does not restore hypoxic pulmonary vasoconstriction in ovine sepsis. Crit Care Med 1997; 25:1551-1559
13. 13. Fischer SR, Deyo DJ, Bone HG, et al: Nitric oxide synthase inhibition restores hypoxic pulmonary vasoconstriction in sepsis. Am J Respir Crit Care Med 1997; 156:833-839
14. 14. Noda H, Noshima S, Nakazawa H, et al: Left ventricular dysfunction and acute lung injury induced by continuous administration of endotoxin in sheep. Shock 1994; 1:291-298
15. 15. Lingnau W, McGuire R, Dehring DJ, et al: Change in regional hemodynamics after nitric oxide inhibition during ovine bacteremia. Am J Physiol 1996; 39:R207-R216
16. 16. Hinder F, Booke M, Traber LD, et al: Nitric oxide synthase inhibition during experimental sepsis improves renal excretory function in the presence of chronically elevated atrial natriuretic peptide. Crit Care Med 1996; 24: 131-136
17. 17. Hinder F, Booke M, Traber LD, et al: The atrial natriuretic peptide receptor antagonist HS 142-1 improves cardiovascular filling and mean arterial pressure in a hyperdynamic ovine model of sepsis. Crit Care Med 1997; 25:820-826
18. 18. Nelson SH, Ehardt JS, Lingnau W, et al: Differential effects of prolonged septicemia on isolated pulmonary arteries and veins from sheep. Shock 1996; 5:440-445