Diaspirin cross-linked Hb and norepinephrine prevent the sepsis-induced increase in critical O2 delivery

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 279, Issue 4 48-4, 2000, Pages

  Sielenkämper, Andreas W ^a   Yu, Pei ^a   Eichelbrönner, Otto ^a   MacDonald, Tammy ^a   Martin, Claudio M ^a   Chin Yee, Ian H ^a   Sibbald, William J ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

Anemic hypoxia; Blood substitute; Cardiovascular; Rat

Indexed keywords

BLOOD SUBSTITUTE; DIASPIRIN CROSSLINKED HEMOGLOBIN; NORADRENALIN; OXYGEN;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SUBSTITUTION; CONTROLLED STUDY; HEMODILUTION; HEMODYNAMICS; HYPOXIA; MALE; MICROCIRCULATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SEPSIS; TISSUE METABOLISM;

EID: 0033680697     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.279.4.h1922     Document Type: Article

References (40)

1. Effects of endogenous and exogenous catecholamines on LPS-induced neutrophil trafficking and activation
2. Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
3. Diaspirin crosslinked hemoglobin (DCLHb): Characterization of the process and the product manufactured under GMP requirements for clinical studies
4. Circulatory disturbances in multiple systems organ failure
5. In vivo effects of Escherichia coli endotoxemia on diaphragmatic microcirculation in rats
6. Sepsis and its complications: The clinical problem
7. Hemodilution induces stable changes in global cardiovascular and regional myocardial function
8. Isolation and characterization of a new hemoglobin derivative cross-linked between the α chains (lysine 99(α1), lysine 99(α2))
9. Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis
10. Quantitated left ventricular systolic mechanics in children with septic shock utilizing noninvasive wall-stress analysis
11. Transfusing RBCs stored in CPDA-1 for 28 days fails to improve tissue oxygenation in rats
12. 2-adrenoreceptor activation
13. Role of ET and NO in resuscitative effect of diaspirin cross-linked hemoglobin after hemorrhage in rat
14. Actions of diaspirin cross-linked hemoglobin on isolated rat and dog vessels
15. Fluid loading increases oxygen consumption in septic patients with lactate acidosis
16. Histologic and ultrastructural changes in nonpulmonary organs during early hyperdynamic sepsis
17. Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway
18. The acute respiratory distress syndrome
19. Microvascular perfusion is impaired in a rat model of normotensive sepsis
20. Dopexamine attenuates flow motion in ileal mucosal arterioles in normotensive sepsis
21. Differential impairment of vascular reactivity of small pulmonary and systemic arteries in hyperdynamic sepsis
22. Preparation and characterization of diaspirin cross-linked hemoglobin solutions for preclinical studies
23. 2 uptake during endotoxemia
24. Oxygen transport by erythrocyte/hemoglobin solution mixtures in an in vitro capillary as a model of hemoglobin-based oxygen carrier performance
25. Structure-function relationships in the septic rat heart
26. 2 delivery from experimental data: Sensitivity to error
27. Oxygen delivery and uptake by peripheral tissues: Physiology and pathophysiology
28. Role of NO mechanism in cardiovascular effects of diaspirin cross-linked hemoglobin in anesthetized rats
29. Blood substitutes - Effects on the microcirculation
30. Diaspirin crosslinked hemoglobin improves systemic oxygen uptake in oxygen supply-dependent septic rats
31. Diaspirin crosslinked hemoglobin improves mucosal perfusion in the ileum of septic rats
32. Bovine haemoglobin is more potent than autologous red blood cells in restoring muscular tissue oxygenation after profound isovolemic haemodilution in dogs
33. Practice parameters for hemodynamic support of sepsis in adult patients in sepsis
34. Inhibition of inducible nitric oxide synthase ameliorates lipopolysaccharide-induced gut mucosal barrier dysfunction in rats
35. Oxygen uptake/supply-dependency: Effects of short-term dobutamine infusion
36. Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: Theory
37. Hypoxic hypoxia
38. Ultrastructural changes in skeletal muscle mitochondria in Gram-negative sepsis
39. Physiological significance of oxygen dissociation curve shifts
40. Effects of norepinephrine on regional blood flow and oxygen extraction capabilities during endotoxic shock