Mucosal output of eotaxin in allergic rhinitis and its attenuation by topical glucocorticosteroid treatment

Clinical and Experimental Allergy

Volumn 31, Issue 8, 2001, Pages 1321-1327

  Greiff, L ^a   Petersen, H ^b   Mattsson, E ^a   Andersson, M ^a   Erjefalt J S ^a   Linden, M ^c   Svensson, C ^a   Persson, C G A ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Reykjavik City Hospital   (Iceland)

^c Astra Draco ^*  (Sweden)

Author keywords

Airway; Allergy; Cytokines; Eosinophils; Inflammation

Indexed keywords

ALLERGEN; ALPHA 2 MACROGLOBULIN; BUDESONIDE; EOSINOPHIL CATIONIC PROTEIN; EOTAXIN; GLUCOCORTICOID; PLACEBO;

ADULT; ALLERGIC RHINITIS; ARTICLE; BIOPSY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NOSE MUCOSA; NOSE MUCUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; ALLERGENS; ALPHA-MACROGLOBULINS; ANTI-INFLAMMATORY AGENTS; BLOOD PROTEINS; BUDESONIDE; CHEMOKINES, CC; CHEMOTACTIC FACTORS, EOSINOPHIL; CYTOKINES; DOUBLE-BLIND METHOD; EOSINOPHIL GRANULE PROTEINS; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; NASAL LAVAGE FLUID; NASAL MUCOSA; POACEAE; POLLEN; RHINITIS, ALLERGIC, SEASONAL; RIBONUCLEASES;

EID: 0035724269     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2001.01029.x     Document Type: Article

References (28)

1. Eosinophil cationic protein in nasopharyngeal secretions and serum of infants infected with respiratory syncytial virus
2. 2-macroglobulin in human rhinovirus-induced common cold
3. The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation in the lung in vivo
4. Eotaxin: A potent eosinophil chemoattractant cytokine detected in a guinea-pig model of allergic airways inflammation
5. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia
6. Cloning of the human eosinophil chemoattractant, eotaxin: Expression, receptor binding, and functional properties suggest a mechanism for selective recruitment of eosinophils
7. Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but is not restricted to a Th2-type response
8. Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung
9. Identification of cytokine and adhesion molecule mRNA in murine lung tissue and isolated T cells and eosinophils by semi-quantitative reverse transcriptase-polymerase chain reaction
10. Eotaxin protein and gene expression in guinea pig lungs: Constitutive expression and upregulation after allergen challenge
11. Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airway disease: Analysis in a guinea pig model in vivo
12. Eotaxin may regulate homing of eosinophils to airway epithelium: Immunocytochemical and in situ hybridisation studies in naive and allergen challenged guinea-pigs
13. Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis
14. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells
15. Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation
16. Experimental common cold increases mucosal output of eotaxin in atopic individuals
17. Epithelium, microcirculation, and eosinophils - New aspects of the allergic airway in vivo
18. The 'Nasal Pool' device for challenge and lavage of the nasal mucosa in children: Histamine-induced plasma exudation responses
19. Targeted disruption of the chemokine partially reduces antigen-induced tissue eosinophilia
20. Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways
21. Interleukin-5 gene expression in nasal mucosa and changes in amount of interleukin-5 in nasal lavage after allergen-challenge
22. Secretion of chemokines and other cytokines in allergen-induced nasal responses: Inhibition by topical steroid treatment
23. Proinflammatory cytokines in nasal secretions of allergic subjects after antigen challenge
24. RANTES in human allergen-induced rhinitis: Cellular source and relation to tissue eosinophilia
25. The eosinophil and asthma
26. Eosinophils, secretory responsiveness and glucocorticoid-induced effects on the nasal mucosa during a weak pollen season