-
1
-
-
0037417254
-
Alzheimer's disease and Parkinson's disease
-
Nussbaum R.L. Ellis C.E. Alzheimer's disease and Parkinson's disease N. Engl. J. Med 348 2003 1356-1364
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1356-1364
-
-
Nussbaum, R.L.1
Ellis, C.E.2
-
2
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J. Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353-356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
3
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy J.A. Higgins G.A. Alzheimer's disease: The amyloid cascade hypothesis Science 256 1992 184-185
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
4
-
-
11544279355
-
Diffusible, non-fibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
-
Lambert M.P. et al. Diffusible, non-fibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins Proc. Natl. Acad. Sci. U.S.A 95 1998 6448-6453
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
-
5
-
-
0033520461
-
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates
-
Walsh D.M. et al. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates J. Biol. Chem 274 1999 25945-25952
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 25945-25952
-
-
Walsh, D.M.1
-
6
-
-
0037975676
-
Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β
-
Hoshi M. et al. Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β Proc. Natl. Acad. Sci. U.S.A 100 2003 6370-6375
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 6370-6375
-
-
Hoshi, M.1
-
7
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh D.M. et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo Nature 416 2002 535-539
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
-
8
-
-
0030799122
-
Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate
-
Walsh D.M. et al. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate J. Biol. Chem 272 1997 22364-22372
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22364-22372
-
-
Walsh, D.M.1
-
9
-
-
0030614627
-
Observation of metastable Abeta amyloid protofibrils by atomic force microscopy
-
Harper J.D. et al. Observation of metastable Abeta amyloid protofibrils by atomic force microscopy Chem. Biol 4 1997 119-125
-
(1997)
Chem. Biol.
, vol.4
, pp. 119-125
-
-
Harper, J.D.1
-
10
-
-
0037551741
-
Protofibrils, pores, fibrils and neurodegeneration: Separating responsible protein aggregates from the innocent bystanders
-
Caughey B. Lansbury P.T. Protofibrils, pores, fibrils and neurodegeneration: Separating responsible protein aggregates from the innocent bystanders Annu. Rev. Neurosci 26 2003 267-298
-
(2003)
Annu. Rev. Neurosci.
, vol.26
, pp. 267-298
-
-
Caughey, B.1
Lansbury, P.T.2
-
11
-
-
0037130174
-
Neurodegenerative disease: Amyloid pores from pathogenic mutations
-
Lashuel H.A. et al. Neurodegenerative disease: Amyloid pores from pathogenic mutations Nature 418 2002 291
-
(2002)
Nature
, vol.418
, pp. 291
-
-
Lashuel, H.A.1
-
12
-
-
0042838303
-
Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
-
Gong Y. et al. Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss Proc. Natl. Acad. Sci. U.S.A 100 2003 10417-10422
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 10417-10422
-
-
Gong, Y.1
-
13
-
-
0035993237
-
Aβ toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets
-
Klein W.L. et al. Aβ toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets Neurochem. Int 41 2002 345-352
-
(2002)
Neurochem. Int.
, vol.41
, pp. 345-352
-
-
Klein, W.L.1
-
14
-
-
0037422540
-
Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways
-
Bitan G. et al. Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways Proc. Nat. Acad. Sci. U.S.A 100 2003 330-335
-
(2003)
Proc. Nat. Acad. Sci. U.S.A.
, vol.100
, pp. 330-335
-
-
Bitan, G.1
-
15
-
-
0036222552
-
β-Amyloid peptide as a target for treatment of Alzheimer's disease
-
Conde S. β-Amyloid peptide as a target for treatment of Alzheimer's disease Exp. Opin. Ther. Patents 12 2002 503-512
-
(2002)
Exp. Opin. Ther. Patents
, vol.12
, pp. 503-512
-
-
Conde, S.1
-
16
-
-
0035411641
-
β-Amyloid aggregation inhibitors for the treatment of Alzheimer's disease: Dream or reality?
-
Talaga P. β-Amyloid aggregation inhibitors for the treatment of Alzheimer's disease: Dream or reality? Mini-Rev. Med. Chem 1 2001 175-186
-
(2001)
Mini-Rev. Med. Chem.
, vol.1
, pp. 175-186
-
-
Talaga, P.1
-
17
-
-
13444276104
-
Beta sheet breaker peptide analogs that inhibit beta pleated sheet formation in amyloid beta-peptide
-
Axonyx Inc
-
Soto-Jara C. (2004) Beta sheet breaker peptide analogs that inhibit beta pleated sheet formation in amyloid beta-peptide. Patent application No: US6689753, Axonyx Inc
-
(2004)
Patent Application No: US6689753
-
-
Soto-Jara, C.1
-
18
-
-
0036615884
-
Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a β-sheet breaker peptide
-
Permanne B. et al. Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a β-sheet breaker peptide FASEB J 16 2002 860-862
-
(2002)
FASEB J.
, vol.16
, pp. 860-862
-
-
Permanne, B.1
-
19
-
-
0036547110
-
Peptide inhibitors of beta amyloid aggregation
-
Findeis M.A. et al. Peptide inhibitors of beta amyloid aggregation Curr. Topic Med. Chem 2 2002 417-423
-
(2002)
Curr. Topic Med. Chem.
, vol.2
, pp. 417-423
-
-
Findeis, M.A.1
-
20
-
-
13444296073
-
Modulators of beta-amyloid peptide aggregation comprising D-aminoacids
-
Praecis Pharmaceutical Inc
-
Arico-Muendel C.C. et al. (2004) Modulators of beta-amyloid peptide aggregation comprising D-aminoacids. Patent application No: US6689752, Praecis Pharmaceutical Inc
-
(2004)
Patent Application No: US6689752
-
-
Arico-Muendel, C.C.1
-
22
-
-
13444289677
-
Use of the chelating agent clioquinol for the manufacture of a pharmaceutical composition for the treatment of Alzheimer's disease
-
Gerolymatos PN SA
-
Gerolymatos P.N. (1998) Use of the chelating agent clioquinol for the manufacture of a pharmaceutical composition for the treatment of Alzheimer's disease. Patent application No: WO98/06403, Gerolymatos PN SA
-
(1998)
Patent Application No: WO98/06403
-
-
Gerolymatos, P.N.1
-
23
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Aβ amyloid deposition and toxicity in Alzheimer's disease
-
Ritchie C.W. et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Aβ amyloid deposition and toxicity in Alzheimer's disease Arch. Neurol 60 2003 1685-1691
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
-
24
-
-
0036860349
-
Metal complexing agents as therapies for Alzheimer's disease
-
Bush A.I. Metal complexing agents as therapies for Alzheimer's disease Neurobiol. Aging 23 2002 1031-1038
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 1031-1038
-
-
Bush, A.I.1
-
25
-
-
13444277296
-
Emerging themes in Alzheimer's disease: Paradigm shift in drug discovery
-
Morgan, T.E. and Kraft G.A. (2002) Emerging themes in Alzheimer's disease: Paradigm shift in drug discovery. Annu. Rep. Med. Chem. 37, 31-40
-
(2002)
Annu. Rep. Med. Chem.
, vol.37
, pp. 31-40
-
-
Morgan, T.E.1
Kraft, G.A.2
-
26
-
-
0041816383
-
Elucidation of primary structure elements controlling early amyloid β-protein oligomerization
-
Bitan G. et al. Elucidation of primary structure elements controlling early amyloid β-protein oligomerization J. Biol. Chem 278 2003 34882-34889
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34882-34889
-
-
Bitan, G.1
-
27
-
-
0242479694
-
Femtomole immunodetection of synthetic and endogenous amyloid-β oligomers and its application to Alzheimer's disease drug candidate screening
-
Chang L. et al. Femtomole immunodetection of synthetic and endogenous amyloid-β oligomers and its application to Alzheimer's disease drug candidate screening J. Mol. Neurosci 20 2003 305-313
-
(2003)
J. Mol. Neurosci.
, vol.20
, pp. 305-313
-
-
Chang, L.1
-
28
-
-
13444285306
-
Composition useful for treating learning and/or memory disorders, degenerative diseases e.g. Alzheimer's disease, comprises antibodies that interact with soluble, non-fibrillar oligomeric assemblies of amyloid beta proteins
-
Northwestern University
-
Chang L. et al. (2003). Composition useful for treating learning and/or memory disorders, degenerative diseases e.g. Alzheimer's disease, comprises antibodies that interact with soluble, non-fibrillar oligomeric assemblies of amyloid beta proteins. Patent application No. US2003068316, Northwestern University
-
(2003)
Patent Application No. US2003068316
-
-
Chang, L.1
-
29
-
-
0035910374
-
The Gingko biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands
-
Yao Z.X. et al. The Gingko biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands Brain Res 889 2001 181-190
-
(2001)
Brain Res.
, vol.889
, pp. 181-190
-
-
Yao, Z.X.1
-
30
-
-
0242424155
-
Self-assembly of Aβ1-42 into globular neurotoxins
-
Chromy B.A. et al. Self-assembly of Aβ1-42 into globular neurotoxins Biochemistry 42 2003 12749-12760
-
(2003)
Biochemistry
, vol.42
, pp. 12749-12760
-
-
Chromy, B.A.1
-
31
-
-
0141642253
-
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease
-
Ono K. et al. Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease J. Neurochem 87 2003 172-181
-
(2003)
J. Neurochem.
, vol.87
, pp. 172-181
-
-
Ono, K.1
-
32
-
-
13444296605
-
Neuroprotective Spirostenol Pharmaceutical Compositions
-
Samaritan Pharmaceuticals Inc
-
Greeson J. et al. (2003) Neuroprotective Spirostenol Pharmaceutical Compositions. Patent application No: WO03077869, Samaritan Pharmaceuticals Inc.
-
(2003)
Patent Application No: WO03077869
-
-
Greeson, J.1
-
33
-
-
0037248301
-
Alzheimer disease therapy: Can the amyloid cascade be halted?
-
Golde T.E. Alzheimer disease therapy: Can the amyloid cascade be halted? J. Clin. Invest 111 2003 11-18
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 11-18
-
-
Golde, T.E.1
-
34
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
-
Konietzko H.C. et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease Neuron 38 2003 517-518
-
(2003)
Neuron
, vol.38
, pp. 517-518
-
-
Konietzko, H.C.1
-
35
-
-
13444314071
-
Specific Antibodies to Amyloid beta Peptide, Pharmaceutical Compositions and Methods of Use Thereof
-
[Mindset Biopharmaceuticals]
-
Chain D.G. et al. [Mindset Biopharmaceuticals] (2003) Specific Antibodies to Amyloid beta Peptide, Pharmaceutical Compositions and Methods of Use Thereof. Patent application No: WO03074081
-
(2003)
Patent Application No: WO03074081
-
-
Chain, D.G.1
-
36
-
-
1542268206
-
Selective optimization of side activities: Another way for drug discovery
-
Wermuth C.G. Selective optimization of side activities: Another way for drug discovery J. Med. Chem 47 2004 1-12
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1-12
-
-
Wermuth, C.G.1
-
37
-
-
0037044835
-
New class of inhibitors of amyloid-β Fibril formation
-
Lashuel H.A. et al. New class of inhibitors of amyloid-β Fibril formation J. Biol. Chem 277 2002 42881-42890
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42881-42890
-
-
Lashuel, H.A.1
-
38
-
-
0037794384
-
The plasma membrane: A target and hurdle for the development of anti-Aβ drugs?
-
Talaga P. Quéré L. The plasma membrane: A target and hurdle for the development of anti-Aβ drugs? Curr. Drug Targets - CNS & Neurol. Disorders 1 2002 565-572
-
(2002)
Curr. Drug Targets - CNS & Neurol. Disorders
, vol.1
, pp. 565-572
-
-
Talaga, P.1
Quéré, L.2
-
39
-
-
0348047610
-
Living with the enemy: A physiological role for the β-amyloid peptide
-
Esteban J.A. Living with the enemy: A physiological role for the β-amyloid peptide Trends Neurosci 27 2004 1-3
-
(2004)
Trends Neurosci.
, vol.27
, pp. 1-3
-
-
Esteban, J.A.1
-
40
-
-
0038045587
-
The production of amyloid β peptide is a critical requirement for the viability of central neurons
-
Plant L.D. et al. The production of amyloid β peptide is a critical requirement for the viability of central neurons J. Neurosci 23 2003 5531-5535
-
(2003)
J. Neurosci.
, vol.23
, pp. 5531-5535
-
-
Plant, L.D.1
-
41
-
-
0036710570
-
Pharmacotherapy for Alzheimer's disease: Progress and prospects
-
Palmer A.M. Pharmacotherapy for Alzheimer's disease: Progress and prospects Trends Pharm. Sci 23 2002 426-433
-
(2002)
Trends Pharm. Sci.
, vol.23
, pp. 426-433
-
-
Palmer, A.M.1
-
42
-
-
0037369507
-
Drugs targeting Alzheimer's disease: Some things old and some things new
-
Michaelis M.L. Drugs targeting Alzheimer's disease: Some things old and some things new J. Pharmacol. Exp. Ther 304 2003 897-904
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.304
, pp. 897-904
-
-
Michaelis, M.L.1
-
43
-
-
0242268945
-
Immunotherapeutic approaches to Alzheimer's disease
-
Monsonego A. Weiner H.L. Immunotherapeutic approaches to Alzheimer's disease Science 302 2003 834-846
-
(2003)
Science
, vol.302
, pp. 834-846
-
-
Monsonego, A.1
Weiner, H.L.2
-
44
-
-
0036639707
-
Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease
-
Dominguez D.I. De Strooper B. Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease Trends Pharm. Sci 23 2002 324-330
-
(2002)
Trends Pharm. Sci.
, vol.23
, pp. 324-330
-
-
Dominguez, D.I.1
De Strooper, B.2
-
45
-
-
0036242449
-
Advances in the development of Aβ-related therapeutic strategies for Alzheimer's disease
-
Barrow C.J. Advances in the development of Aβ-related therapeutic strategies for Alzheimer's disease Drugs News Perspect 15 2002 102-109
-
(2002)
Drugs News Perspect.
, vol.15
, pp. 102-109
-
-
Barrow, C.J.1
|