Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors

Journal of Medicinal Chemistry

Volumn 42, Issue 11, 1999, Pages 1894-1900

  Costantino, Luca ^a   Rastelli, Giulio ^a   Gamberini, M Cristina ^a   Giovannoni, M Paola ^b   Piaz, Vittorio Dal ^b   Vianello, Paola ^c   Barlocco, Daniela ^c  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Dipto di Scienze Farmaceutiche   (Italy)

^c Istituto Chimico Farmaceutico   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; BUTYRIC ACID DERIVATIVE; ISOXAZOLO [3,4 D] PYRIDAZIN 7 (6H) ONE; PHENYL GROUP; PROPIONIC ACID DERIVATIVE; PYRIDAZINONE DERIVATIVE; SORBINIL; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR MODEL; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALDEHYDE REDUCTASE; ANIMALS; CATTLE; ENZYME INHIBITORS; ISOXAZOLES; LENS, CRYSTALLINE; MODELS, MOLECULAR; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033519699     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981107o     Document Type: Article

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