Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: Relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population

American Journal of Tropical Medicine and Hygiene

Volumn 69, Issue 6, 2003, Pages 569-573

  Boutlis, Craig S ^a   Hobbs, Maurine R ^b   Marsh, Robyn L ^a   Misukonis, Mary A ^c   Tkachuk, Ariana N ^b   Lagog, Moses ^d   Booth, Jennifer ^b   Granger, Donald L ^b   Bockarie, Moses J ^d   Mgone, Charles S ^e   Levesque, Marc C ^c   Weinberg, J Brice ^c   Anstey, Nicholas M ^a  

^a MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

^e African Malaria Network Trust   (Tanzania)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2A PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; CCTTT REPEAT POLYMORPHISM; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDEMIC DISEASE; ENZYME ACTIVITY; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC SELECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VIVO STUDY; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; MAJOR CLINICAL STUDY; MALARIA; MALE; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE REPEAT; OUTCOMES RESEARCH; PAPUA NEW GUINEA; PERIPHERAL BLOOD MONONUCLEAR CELL; PROMOTER REGION; TRANSCRIPTION INITIATION SITE; ABORIGINE; BIOSYNTHESIS; BLOOD; GENETIC PREDISPOSITION; GENETICS;

ENDEMIC DISEASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALARIA; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OCEANIC ANCESTRY GROUP; PAPUA NEW GUINEA; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 1342346795     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2003.69.569     Document Type: Article

References (21)

1. Anstey NM, Weinberg JB, Hassanali MY, Mwaikambo ED, Manyenga D, Misukonis MA, Arnelle DR, Hollis D, McDonald MI, Granger DL, 1996. Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med 184: 557-567.
2. Perkins DJ, Kremsner PG, Schmid D, Misukonis MA, Kelly MA, Weinberg JB, 1999. Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy gabonese children with prior mild or severe malaria. Infect Immun 67: 4977-4981.
3. Chiwakata CB, Hemmer CJ, Dietrich M, 2000. High levels of inducible nitric oxide synthase mRNA are associated with increased monocyte counts in blood and have a beneficial role in Plasmodium falciparum malaria. Infect Immun 68: 394-399.
4. Weinberg JB, Misukonis MA, Shami PJ, Mason SN, Sauls DL, Dittman WA, Wood ER, Smith GK, McDonald B, Bachus KE, 1995. Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages. Blood 86: 1184-1195.
5. St. Clair EW, Wilkinson WE, Lang T, Sanders L, Misukonis MA, Gilkeson GS, Pisetsky DS, Granger DL, Weinberg JB, 1996. Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients. J Exp Med 184: 1173-1178.
6. Burgner D, Xu W, Rockett K, Gravenor M, Charles IG, Hill AV, Kwiatkowski D, 1998. Inducible nitric oxide synthase polymorphism and fatal cerebral malaria. Lancet 352: 1193-1194.
7. Kun JF, Mordmuller B, Lell B, Lehman LG, Luckner D, Kremsner PG, 1998. Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria. Lancet 351: 265-266.
8. Hobbs MR, Udhayakumar V, Levesque MC, Booth J, Roberts JM, Tkachuk AN, Pole A, Coon H, Kariuki S, Nahlen BL, Mwaikambo ED, Lal AL, Granger DL, Anstey NM, Weinberg JB, 2002. A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. Lancet 360: 1468-1475.
9. Burgner D, Usen S, Rockett K, Jallow M, Ackerman H, Cervino A, Pinder M, Kwiatkowski DP, 2003. Nucleotide and haplotypic diversity of the NOS2A promoter region and its relationship to cerebral malaria. Hum Genet 112: 379-386.
10. Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K, 2002. Significant association of longer forms of CCTTT Microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand. J Infect Dis 186: 578-581.
11. Levesque MC, Hobbs MR, Anstey NM, Vaughn TN, Chancellor JA, Pole A, Perkins DJ, Misukonis MA, Chanock SJ, Granger DL, Weinberg JB, 1999. Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. J Infect Dis 180: 1994-2002.
12. Kun JF, Mordmuller B, Perkins DJ, May J, Mercereau-Puijalon O, Alpers M, Weinberg JB, Kremsner PG, 2001. Nitric oxide synthase 2 (Lambarene) (G-954C), increased nitric oxide production, and protection against malaria. J Infect Dis 184: 330-336.
13. Warpeha KM, Xu W, Liu L, Charles IG, Patterson CC, Ah-Fat F, Harding S, Hart PM, Chakravarthy U, Hughes AE, 1999. Genotyping and functional analysis of a polymorphic (CCTTT)(n) repeat of NOS2A in diabetic retinopathy. FASEB J 13: 1825-1832.
14. De Vera ME, Shapiro RA, Nussler AK, Mudgett JS, Simmons RL, Morris SM Jr, Billiar TR, Geller DA, 1996. Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. Proc Natl Acad Sci USA 93: 1054-1059.
15. Boutlis CS, Gowda DC, Naik RS, Maguire GP, Mgone CS, Bockarie MJ, Lagog M, Ibam E, Lorry K, Anstey NM, 2002. Antibodies to Plasmodium falciparum glycosylphosphatidylinositols: inverse association with tolerance of parasitemia in Papua New Guinean children and adults. Infect Immun 70: 5052-5057.
16. Cattani JA, Tulloch JL, Vrbova H, Jolley D, Gibson FD, Moir JS, Heywood PF, Alpers MP, Stevenson A, Clancy R, 1986. The epidemiology of malaria in a population surrounding Madang, Papua New Guinea. Am J Trop Med Hyg 35: 3-15.
17. Burkot TR, Graves PM, Cattani JA, Wirtz RA, Gibson FD, 1987. The efficiency of sporozoite transmission in the human malarias, Plasmodium falciparum and P. vivax. Bull World Health Organ 65: 375-380.
18. Burkot TR, Graves PM, Paru R, Wirtz RA, Heywood PF, 1988. Human malaria transmission studies in the Anopheles punctulatus complex in Papua New Guinea: sporozoite rates, inoculation rates, and sporozoite densities. Am J Trop Med Hyg 39: 135-144.
19. Cox MJ, Kum DE, Tavul L, Narara A, Raiko A, Baisor M, Alpers MP, Medley GF, Day KP, 1994. Dynamics of malaria parasitaemia associated with febrile illness in children from a rural area of Madang, Papua New Guinea. Trans R Soc Trop Med Hyg 88: 191-197.
20. Anstey NM, Boutlis CS, Saunders JR, 2002. Systemic nitric oxide production in human malaria. I. Analysis of NO metabolites in biological fluids. Methods Mol Med 72: 461-467.
21. Boutlis CS, Tjitra E, Maniboey H, Misukonis MA, Saunders JR, Suprianto S, Weinberg JB, Anstey NM, 2003. Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults. Infect Immun 71: 3682-3689.