Modeling pulmonary nitric oxide exchange

Journal of Applied Physiology

Volumn 96, Issue 3, 2004, Pages 831-839

  George, Steven C ^a   Hogman, Marieann ^b   Permutt, Solbert ^c   Silkoff, Philip E ^d  

^a University of California at Irvine   (United States)

^b UPPSALA UNIVERSITY   (Sweden)

^c JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

^d NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Airways; Alveoli; Inflammation; Model; NO

Indexed keywords

NITRIC OXIDE;

AIRWAY; ANALYTIC METHOD; BREATH ANALYSIS; COMPARTMENT MODEL; CONCENTRATION (PARAMETERS); DYNAMICS; EXPIRATORY FLOW RATE; EXPIRED AIR; HUMAN; LUNG ALVEOLUS WALL; LUNG DIFFUSION CAPACITY; LUNG GAS EXCHANGE; LUNG MODEL; PARAMETER; PARTITION COEFFICIENT; PNEUMONIA; PRIORITY JOURNAL; REPRODUCIBILITY; REVIEW; SENSITIVITY AND SPECIFICITY; TECHNIQUE; TRANSPORT KINETICS;

ANIMALS; HUMANS; LUNG; MODELS, BIOLOGICAL; NITRIC OXIDE; PULMONARY GAS EXCHANGE; PULMONARY VENTILATION; RESPIRATORY TRACT INFECTIONS;

EID: 1342346650     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00950.2003     Document Type: Review

References (56)

1. Alving K, Weitzberg E, and Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 6: 1368-1370, 1993.
2. Asano K, Chee CB, and Gaston B. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc Natl Acad Sci USA 91: 10089-10093, 1994.
3. Borland C, Cox Y, and Higenbottam T. Measurement of exhaled nitric oxide in man. Thorax 48: 1160-1162, 1993.
4. Borland CDR and Higenbottam TW. A simultaneous single breath measurement of pulmonary diffusing capacity with nitric oxide and carbon monoxide. Eur Respir J 2: 56-63, 1989.
5. Chambers DC and Ayres JG. Effect of nebulised L- and D-arginine on exhaled nitric oxide in steroid naive asthma. Thorax 56: 602-606, 2001.
6. De Gouw HW, Marshall-Partridge SJ, Van Der Veen H, Van Den Aardweg JG, Hiemstra PS, and Sterk PJ. Role of nitric oxide in the airway response to exercise in healthy and asthmatic subjects. J Appl Physiol 90: 586-592, 2001.
7. DuBois AB, Kelley PM, Douglas JS, and Mohsenin V. Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humans. J Appl Physiol 86: 159-167, 1999.
8. Dweik RA, Comhair SA, Gaston B, Thunnissen FB, Farver C, Thomassen MJ, Kavuru M, Hammel J, Abu-Soud HM, and Erzurum SC. NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response. Proc Natl Acad Sci USA 98: 2622-2627, 2001.
9. Dweik RA, Laskowski D, Abu-Soud HM, Kaneko FT, Hutte R, Stuehr DJ, and Erzurum SC. Nitric oxide synthesis in the lung: regulation by oxygen through a kinetic mechanism. J Clin Invest 101: 660-666, 1998.
10. Gaston B, Drazen JM, Loscalzo J, and Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 149: 538-551, 1994.
11. Girgis RE, Gugnani MK, Abrams J, and Mayes MD. Partitioning of alveolar and conducting airway nitric oxide in scleroderma lung disease. Am J Respir Crit Care Med 165: 1587-1591, 2002.
12. Guenard H, Varene N, and Vaida P. Determination of lung capillary blood volume and membrane diffusing capacity in man by the measurements of NO and CO transfer. Respir Physiol 70: 113-120, 1987.
13. Gustafsson LE, Leone AM, Persson MG, Wiklund NP, and Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun 181: 852-857, 1991.
14. Hall GL, Reinmann B, Wildhaber JH, and Frey U. Tidal exhaled nitric oxide in healthy, unsedated newborn infants with prenatal tobacco exposure. J Appl Physiol 92: 59-66, 2002.
15. Hogman M. Extended NO analysis applied to patients with known altered values of exhaled NO. In: Disease Markers in Exhaled Breath: Basic Mechanism and Clinical Application, edited by Marczin N and Yacoub MH. New York: Dekker, 2003.
16. Hogman M, Drca N, Ehrstedt C, and Merilainen P. Exhaled nitric oxide partitioned into alveolar, lower airways and nasal contributions. Respir Med 94: 985-991, 2000.
17. Hogman M, Holmkvist T, Walinder R, Merilainen P, Ludviksdottir D, Hakansson L, and Hedenstrom H. Increased nitric oxide elimination from the airways after smoking cessation. Clin Sci (Lond) 103: 15-19, 2002.
18. Hogman M, Holmkvist T, Wegener T, Emtner M, Andersson M, Hedenstrom H, and Merilainen P. Extended NO analysis applied to patients with COPD, allergic asthma and allergic rhinitis. Respir Med 96: 24-30, 2002.
19. Hogman M, Stromberg S, Schedin U, Frostell C, Hedenstierna G, and Gustaffson LE. Nitric oxide from the human respiratory tract efficiently quantified by standardised single breath measurements. Acta Physiol Scand 159: 345-346, 1997.
20. Hyde RW, Geigel EJ, Olszowka AJ, Krasney JA, Forster RE 2nd, Utell MJ, and Frampton MW. Determination of production of nitric oxide by lower airways of humans - theory. J Appl Physiol 82: 1290-1296, 1997.
21. Ignarro LJ, Buga GM, Woods KS, and Byrns RE. Endothelium derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84: 9265-9269, 1987.
22. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, and Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 343: 133-135, 1994.
23. Kotaru C, Coreno A, Skowronski M, Ciufo R, and McFadden ER Jr. Exhaled nitric oxide and thermally induced asthma. Am J Respir Crit Care Med 163: 383-388, 2001.
24. Lehtimäki L, Kankaanranta H, Saarelainen S, Hahtola P, Järvenpää R, Koivula T, Turjanmaa V, and Moilanen E. Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation. Am J Respir Crit Care Med 163: 1557-1561, 2001.
25. Lehtimaki L, Kankaanranta H, Saarelainen S, Turjanmaa V, and Moilanen E. Inhaled fluticasone decreases bronchial but not alveolar nitric oxide output in asthma. Eur Respir J 18: 635-639, 2001.
26. Lehtimaki L, Turjanmaa V, Kankaanranta H, Saarelainen S, Hahtola P, and Moilanen E. Increased bronchial nitric oxide production in patients with asthma measured with a novel method of different exhalation flow rates. Ann Med 32: 417-423, 2000.
27. Lundberg JO, Farkas-Szallasi T, Weitzberg E, Rinder J, Lidholm J, Anggaard A, Hokfelt T, Lundberg JM, and Alving K. High nitric oxide production in human paranasal sinuses. Nat Med 1: 370-373, 1995.
28. Martinez T, Weist A, Williams T, Clem C, Silkoff P, and Tepper RS. Assessment of exhaled nitric oxide kinetics in healthy infants. J Appl Physiol 94: 2384-2390, 2003.
29. Massaro AF, Gaston B, Kita D, Fanta C, Stamler JS, and Drazen JM. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med 152: 800-803, 1995.
30. Pawloski JR, Hess DT, and Stamler JS. Export by red blood cells of nitric oxide bioactivity. Nature 409: 622-626, 2001.
31. Pedroletti C, Hogman M, Merilainen K, Nordvall LS, Hedlin G, and Alving K. Nitric oxide airway diffusing capacity and mucosal concentration in asthmatic schoolchildren. Pediatr Res 54: 496-501, 2003.
32. Perillo IB, Hyde RW, Olszowka AJ, Pietropaoli AP, Frasier LM, Torres A, Perkins PT, Forster RE 2nd, Utell MJ, and Frampton MW. Chemiluminescent measurements of nitric oxide pulmonary diffusing capacity and alveolar production in humans. J Appl Physiol 91: 1931-1940, 2001.
33. Pietropaoli AP, Perillo IB, Torres A, Perkins PT, Frasier LM, Utell MJ, Frampton MW, and Hyde RW. Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans. J Appl Physiol 87: 1532-1542, 1999.
34. Sapienza MA, Kharitonov SA, Horvath I, Chung KF, and Barnes PJ. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 53: 172-175, 1998.
35. Shin HW and George SC. Impact of axial diffusion on nitric oxide exchange in the lungs. J Appl Physiol 93: 2070-2080, 2002.
36. Shin HW, Rose-Gottron CM, Cooper DM, Hill MA, and George SC. Impact of high-intensity exercise on flow-independent NO exchange parameters. Med Sci Sports Exerc 35: 995-1003, 2003.
37. Shin HW, Rose-Gottron CM, Cooper DM, Newcombe RL, and George SC. Airway diffusing capacity of nitric oxide and steroid therapy in asthma. J Appl Physiol 96: 65-75, 2004.
38. Shin HW, Rose-Gottron CM, Perez F, Cooper DM, Wilson AF, and George SC. Flow-independent nitric oxide exchange parameters in healthy adults. J Appl Physiol 91: 2173-2181, 2001.
39. Shin HW, Rose-Gottron CM, Sufi RS, Perez F, Cooper DM, Wilson AF, and George SC. Flow-independent nitric oxide exchange parameters in cystic fibrosis. Am J Respir Crit Care Med 165: 349-357, 2002.
40. Shin HY and George SC. Microscopic modeling of NO and S-nitrosoglutathione kinetics and transport in human airways. J Appl Physiol 90: 777-788, 2001.
41. Silkoff PE, McClean PA, Caramori M, Slutsky AS, and Zamel N. A significant proportion of exhaled nitric oxide arises in large airways in normal subjects. Respir Physiol 113: 33-38, 1998.
42. Silkoff PE, McClean PA, Slutsky AS, Furlott HG, Hoffstein E, Wakita S, Chapman KR, Szalai JP, and Zamel N. Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am J Respir Crit Care Med 155: 260-267, 1997.
43. Silkoff PE, Sylvester JT, Zamel N, and Permutt S. Airway nitric oxide diffusion in asthma. Role in pulmonary function and bronchial responsiveness. Am J Respir Crit Care Med 161: 1218-1228, 2000.
44. Snyder AH, McPherson ME, Hunt JF, Johnson M, Stamler JS, and Gaston B. Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis. Am J Respir Crit Care Med 165: 922-926, 2002.
45. Stamler JS, Jia L, Eu JP, McMahon TJ, Demchenko IT, Bonaventura J, Gernert K, and Piantadosi CA. Blood flow regulation by S-nitrosohemoglobin in the physiological gradient. Science 276: 2034-2037, 1997.
46. Tsoukias NM, Dabdub D, Wilson AF, and George SC. Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs: I. Theory. Respir Physiol 120: 231-250, 2000.
47. Tsoukias NM and George SC. A two-compartment model of pulmonary nitric oxide exchange dynamics. J Appl Physiol 85: 653-666, 1998.
48. Tsoukias NM and George SC. Impact of volume-dependent alveolar diffusing capacity on exhaled nitric oxide concentration. Ann Biomed Eng 29: 731-739, 2001.
49. Tsoukias NM, Shin HW, Wilson AF, and George SC. A single-breath technique with variable flow rate to characterize nitric oxide exchange dynamics in the lungs. J Appl Physiol 91: 477-487, 2001.
50. 2 in humans: effect of dynamically changing flow rate. J Appl Physiol 85: 642-652, 1998.
51. Tsoukias NM, Wilson AF, and George SC. Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs: II. Experiment. Respir Physiol 120: 251-271, 2000.
52. Van Muylem A, Noel C, and Paiva M. Modeling of impact of gas molecular diffusion on nitric oxide expired profile. J Appl Physiol 94: 119-127, 2003.
53. Van's Gravesande KS, Wechsler ME, Grasemann H, Silverman ES, Le L, Palmer LJ, and Drazen JM. Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levels. Am J Respir Crit Care Med 168: 228-231, 2003.
54. Wechsler ME, Grasemann H, Deykin A, Silverman EK, Yandava CN, Israel E, Wand M, and Drazen JM. Exhaled nitric oxide in patients with asthma: association with NOS1 genotype. Am J Respir Crit Care Med 162: 2043-2047, 2000.
55. Yates DH, Kharitonov SA, Robbins RA, Thomas PS, and Barnes PJ. Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am J Respir Crit Care Med 152: 892-896, 1995.
56. Yates DH, Kharitonov SA, Thomas PS, and Barnes PJ. Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase. Am J Respir Crit Care Med 154: 247-250, 1996.