In vivo tracer transport through the lacunocanalicular system of rat bone in an environment devoid of mechanical loading

Bone

Volumn 22, Issue 2, 1998, Pages 107-117

  Knothe Tate, M L ^a,b   Niederer, P ^b   Knothe, U ^c  

^a ETH ZURICH   (Switzerland)

^b AO RESEARCH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Bone; Fluid flow; Molecular transport; Osteocyte; Tracer

Indexed keywords

AMINO ACID; PEROXIDASE; PROCION RED; PROTEIN; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEFORMATION; BONE MATRIX; BONE STRUCTURE; CAPILLARY; CONTROLLED STUDY; DIFFUSION; EXTRAVASCULAR SPACE; FEMALE; FLOW; FLUID TRANSPORT; IMMATURITY; MALE; METACARPAL BONE; MOLECULAR WEIGHT; NONHUMAN; OSTEOCYTE; PROTEIN TRANSPORT; RAT; SOFT TISSUE; TIBIA; TRABECULAR BONE;

AGE FACTORS; ANIMALS; BIOLOGICAL TRANSPORT; BONE MATRIX; COLORING AGENTS; DIFFUSION; FEMALE; HISTOCYTOCHEMISTRY; HORSERADISH PEROXIDASE; MALE; METACARPUS; MOLECULAR WEIGHT; OSTEOCYTES; PEROXIDASES; RATS; RATS, SPRAGUE-DAWLEY; TIBIA; TRIAZINES; WEIGHT-BEARING;

EID: 0031975298     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(97)00234-2     Document Type: Article

References (63)

1. Adams P. A. Microperoxidases and iron porphyrins. Everse J., Everse K. E., Grisham M. B. Peroxidases in Chemistry and Biology. Vol. II:1991;171-200 CRC, Boca Raton, FL.
2. Atkinson P. J., Hallsworth A. S. The spatial structure of bone. Harrison R. J., Navaratman V. Progress in Anatomy. Vol. 2:1982;179-199 Cambridge University Press, Cambridge.
3. Ascenzi A., Bonucci E., Bocciarelli D. S. An electron microscope study of osteon calcification. Ultrastruct Res. 12:1965;287-303.
4. Ayasaka N., Kondo T., Goto T., Kido M. A., Nagata E., Tanaka T. Differences in the transport systems between cementocytes and osteocytes in rats using microperoxidase as a tracer. Arch Oral Biol. 37:1992;363-369.
5. Baud C. A. Submicroscopic structure and functional aspects of the osteocyte. Clin Orthop Relat Res. 56:1968;227-236.
6. 45Ca clearance by the tibia in the immature dog. Am J Physiol. 216:1969;1150-1157.
7. Bushinsky D. A., Chabala J. M., Levi-Setti R. Ion microprobe analysis of mouse calvariae in vitro Evidence for a "bone membrane." Am J Physiol. 256:1989;E152-E158.
8. Chakkalakal D. A. Mechanoelectric transduction in bone. J Mater Res. 4:1989;1034-1046.
9. Civitelli R. Cell-cell communication in bone. Calcif Tissue Int. 56:(Suppl.):1995;S29-S31.
10. Cooper R. R., Milgram J. W., Robinson R. A. Morphology of the osteon. An electron microscopic study. J Bone Jt Surg. 48-A:1966;1239-1271.
11. Copenhaver W. M. Copenhaver W. M., Bunge R. P., Bunge M. B. Bailey's Textbook of Histology. 1964;122-123 Williams & Wilkins, Baltimore.
12. Cotran R. S., Karnowsky M. J. Vascular leakage induced by horseradish peroxidase in the rat. Proc Soc Exp Biol NY. 126:1967;557-561.
13. Davies D. R. A., Bassingthwaighte J. B., Kelly P. J. Transcapillary exchange of strontium and sucrose in canine tibia. J Appl Physiol. 40:1976;17-22.
14. De Bruyn P. P. H., Michelson S., Bankston P. W. In-vivo endocytosis by bristle-coated pits and intracellular transport of endogenous albumin in the endothelium of the sinuses of liver and bone marrow. Cell Tissue Res. 240:1985;1-7.
15. Dillaman R. M. Movement of ferritin in the 2-day-old chick femur. Anat Rec. 209:1984;445-453.
16. Dillaman R. M., Roer R. D., Gay D. M. Fluid movement in bone Theoretical and empirical . J Biomech. 24:1991;163-177.
17. Doty S. B., Schofield B. H. Metabolic and structural changes within osteocytes of rat bone. Talmage R. V., Munson P. L. Calcium, Parathyroid Hormone and the Calcitonins. 1972;353-364 Elsevier, Amsterdam.
18. Doty, S. B., Robinson, R. A., and Schofield, B. Morphology of bone and histochemical staining characteristics of bone cells. In: Greep, R. O. and Astwood, E. B., Eds. Handbook of Physiology - Endocrinology. Vol. 2. 1976; 3-23.
19. Doty S. B. Morphological evidence of gap junctions between bone cells. Calcif Tissue Int. 33:1981;509-512.
20. Frost H. M. Measurement of osteocytes per unit volume and volume components of osteocytes and canaliculae in man. Henry Ford Hosp Med Bull. 8:1960;208-211.
21. Frost H. M. The osteocyte as a pump. Bone Modeling and Skeletal Modeling Errors. Orthopaedic Lectures. Vol. 4:1973;119-149 Thomas, Springfield, IL.
22. Graham R. C. Jr, Karnovsky M. J. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney Ultrastructural cytochemistry by a new technique . J Histochem Cytochem. 14:1966;291-302.
23. Greenwald A. S., Haynes D. W. A pathway for nutrients from the medullary cavity to the articular cartilage of the human femoral head. J Bone Jt Surg. 51-B:1969;747-753.
24. Grisham M. B., Everse J. Peroxidant activity of hemoglobin and myoglobin. Everse J., Everse K. E., Grisham M. B. Peroxidases in Chemistry and Biology. Vol. I:1991;335-343 CRC, Boca Raton, FL.
25. Groer P. G., Marshall J. H. Mechanism of calcium exchange at bone surfaces. Calcif Tissue Res. 12:1973;175-192.
26. Gross P. M., Marcus M. L., Heistad D. D. Measurement of blood flow to bone and marrow in experimental animals by means of the microsphere technique. J Bone Jt Surg. 63-A:1981;1028-1031.
27. Handagama P. J., Shuman M. A., Bainton D. F. Incorporation of intravenously injected albumin, immunoglobulin G and fibrinogen in guinea pig megakaryocyte granules. J Clin Invest. 84:1989;73-82.
28. Holmes J. M., Davies D. H., Meath W. J., Beebe R. A. Gas adsorption and surface structure of bone mineral. Biochemistry. 3:1964;2019-2024.
29. Holtrop M. E., Weinger J. M. Metabolic and structural changes within osteocytes of rat bone. Talmage R. V., Munson P. L. Calcium, Parathyroid Hormone and the Calcitonins. 1972;365-374 Excerpta Medica, Amsterdam.
30. Hughes S., Davies R., Khan R., Kelly P. Fluid space in bone. Clin Orthop Rel Res. 134:1978;332-341.
31. Karnovsky M. J. The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. J Cell Biol. 35:1967;213-236.
32. Knothe Tate, M. L., Niederer, P., Tepic, S., and Perren, S. M. The role of convective transport in bone physiology and functional adaptation. In: Transactions of the Combined Orthopaedic Research Societies Meeting, San Diego, CA; 1995.
33. Knothe Tate, M. L., Niederer, P., and Tepic, S. Convective transport: A possible modulating factor in bone remodeling and metabolism. In: Transactions of the 42nd Annual Meeting of the Orthopaedic Research Society, Atlanta, GA; 1996.
34. Knothe Tate, M. L., Niederer, P., Tepic, S., and Perren, S. M. Study of convective transport in compact bone as a modulating factor in bone structure and regeneration. In: Transactions of the European Society of Biomechanics Meeting, Leuven, Belgium; 1996.
35. Knothe Tate, M. L. and Knothe, U. An ex vivo model to study transport processes and fluid flow in loaded bone. J Biomech. To be published.
36. Knothe Tate, M. L., Niederer P., Tepic, S., and Perren S. M. In vitro investigation of deformation-induced fluid displacement in small cylindrical specimens excised from cortical sheep bone. In: Transactions of the 43rd Annual Meeting of the Orthopaedic Research Society, San Francisco, CA; 1997.
37. Knothe Tate, M. L., Knothe, U., Niederer, P., Tepic, S., and Perren, S. M. Investigation of load-induced interstitial fluid flow in an ex vivo model of the sheep forelimb. In: Transactions of the 43rd Annual Meeting of the Orthopaedic Research Society, San Francisco, CA; 1997.
38. Knothe Tate M. L., Niederer P., Forwood M. In vivo observation of load-induced fluid displacements using procion red and microperoxidase tracers in the rat tibia. J Bone Miner Res. 12:(Suppl. 1):1997;F461.
39. Lorenz M., Plenk H. A perfusion method of incubation to demonstrate horseradish peroxidase in bone. Histochemistry. 53:1977;257-263.
40. Lozupone E., Nico B., Mancini L., Favia A., Lamanna M. P., Cagiano R. The dynamic of the flow of the interstitial fluid into the osteocytic lacunae and canaliculi of bone cultured in vitro. Bone. 19:(Suppl. 3):1996;150S.
41. Lucht U. Absorption of peroxidase by osteoclasts as studied by electron microscope histochemistry. Histochemie. 29:1972;274-286.
42. McDougall W. A. Pathways of penetration and effects of horseradish peroxidase in rat molar gingiva. Arch Oral Biol. 14:1970;621-633.
43. McDougall W. A. Penetration pathways of a topically applied foreign protein into rat gingiva. J Periodont Res. 6:1971;89-99.
44. Morris M. A., Lopez-Curto J. A., Hughes S. P. F., An K.-N., Bassingthwaighte J. B., Kelly P. J. Fluid spaces in canine bone and marrow. Microvasc Res. 23:1982;188-200.
45. Nachemson A., Lewin T., Maroudas A., Freeman M. A. R. In vitro diffusion of dye through the end plates and annulus fibrosus of human lumbar intervertebral discs. Acta Orthop Scand. 41:1970;589-607.
46. Neuman M. W., Neuman W. F. On the measurement of water compartments, pH and gradients in calvaria. Calcif Tissue Int. 31:1980;135-145.
47. Neuman W. F., Neuman M. W. Studies of diffusion in calvaria. Calcif Tissue Int. 33:1981;441-444.
48. Norimatsu H., Talmage R. V. Influence of calcitonin on the initial uptake of lead and mercury by bone. Proc Soc Exp Biol Med. 161:1979;94-98.
49. Owen M., Triffit J. T., Melick R. A. Albumin in bone. Hard Tissue Growth, Repair and Remineralization. Ciba Foundation Symposium 11. 1973;Excerpta Medica, Amsterdam.
50. Owen M., Triffit J. T. Extravascular albumin in bone tissue. J Physiol. 257:1976;293-307.
51. Pappenheimer J. R. Über die Permeabilität der Glomerulummembranen in der Niere. Klin Wochenschr. 33:1955;362-365.
52. Piekarski K., Munro M. Transport mechanism operating between blood supply and osteocytes in long bones. Nature. 269:1977;80-82.
53. Prescott G. H., Mitchell D. F., Fahmy H. Procion dyes as matrix markers in growing bone and teeth. Am J Phys Anthrop. 29:1968;219-224.
54. Quinlan W. R., Hall B. B., Fitzgerald R. H. Fluid spaces in normal and osteomyelitic canine bone. J Lab Clin Med. 102:1983;78-87.
55. Rahn B. A. Intra vitam staining techniques. von Recum A. F. Handbook of Biomaterials Evaluation. 1986;471-487 MacMillan, New York.
56. Sasaki T., Yamaguchi A., Higashi S., Yoshiki S. Uptake of horseradish peroxidase by bone cells during endochondral bone development. Cell Tissue Res. 239:1985;547-553.
57. Seliger W. G. Tissue fluid movement in compact bone. Anat Rec. 166:1970;247-255.
58. Tanaka T. Transport pathway and uptake of microperoxidase in the junctional epithelium of healthy rat gingiva. J Periodont Res. 19:1984;26-39.
59. Tanaka T., Sakano A. Differences in permeability of microperoxidase and horseradish peroxidase into the alveolar bone of developing rats. J Dent Res. 64:1985;870-876.
60. Tonna, E. A. Bone tracers: Cell and tissue level techniques. In: Skeletal Research. New York: Academic; 1979; 487-463.
61. Wasserman F., Yaeger J. A. Fine structure of the osteocyte capsule and of the wall of the lacunae in bone. Zeitschrift Zellforschung. 67:1965;636-652.
62. Weinbaum S., Cowin S. C., Zeng Y. A model for the excitation of osteocytes by mechanical loading induced bone shear stresses. J Biomech. 27:1994;339-360.
63. Weinstein E., Mandel I. D., Salkind A., Oshrain H. I., Pappas G. D. Studies of gingival fluid. Periodontics. 5:1967;161-166.