Mathematical models of HIV and the immune system

Novartis Foundation Symposium

Volumn 254, Issue , 2003, Pages 193-215

  Wodarz, Dominik ^a   Littlejohn, ^b   Rammensee, ^b  

^a USA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

BIOLOGICAL MODEL; BIOLOGY; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; MATHEMATICS; REVIEW; VIROLOGY;

ALLERGY AND IMMUNOLOGY; ANTI-HIV AGENTS; COMPUTATIONAL BIOLOGY; HIV; HIV INFECTIONS; HUMANS; MATHEMATICS; MODELS, IMMUNOLOGICAL;

EID: 1342310853     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (27)

1. Bonhoeffer S, May RM, Shaw GM, Nowak MA 1997 Virus dynamics and drug therapy. Proc Natl Acad Sci USA 94:6971-6976
2. Bonhoeffer S, Rembiszewski M, Ortiz GM, Nixon DF 2000 Risks and benefits of structured antiretroviral drug therapy interruptions in HIV-1 infection. Aids 14:2313-2322
3. Borrow P, Tishon A, Lee S et al 1996 CD40L-deficient mice show deficits in antiviral immunity - and have an impaired memory CD8+ CTL response. J Exp Med 183:2129-2142
4. + cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection. J Virol 72:7440-7449
5. Chun TW, Stuyver L, Mizell SB et al 1997 Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci USA 94:13193-13197
6. Coffin JM 1995 HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267:483-489
7. De Boer RJ, Perelson AS 1998 Target cell limited and immune control models of HIV infection: a comparison. J Theor Biol 190:201-214
8. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M 1995 Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123-126
9. Jeffery KJ, Usuku K, Hall SE et al 1999 HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc Natl Acad Sci USA 96:3848-3853
10. + T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 189:991-998
11. Kalams SA, Goulder PJ, Shea AK et al 1999 Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy. J Virol 73:6721-6728
12. Klenerman P, Phillips RE, Rinaldo CR et al 1996 Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection. Proc Natl Acad Sci USA 93:15323-15328
13. Komarova NL, Barnes E, Klenerman P, Wodarz D 2003 Boosting immunity by antiviral drug therapy: a simple relationship among timing, efficacy, and success. Proc Natl Acad Sci USA 100:1855-1860
14. Lifson JD, Rossio JL, Arnaout R et al 2000 Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment. J Virol 74:2584-2593
15. + lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J Virol 75:10187-10199
16. Nowak MA, Bangham CR 1996 Population dynamics of immune responses to persistent viruses. Science 272:74-79
17. Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD 1996 HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271:1582-1586
18. Perelson AS, Essunger P, Cao Y et al 1997 Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387:188-191
19. Rosenberg ES, Altfeld M, Poon SH et al 2000 Immune control of HIV-1 after early treatment of acute infection. Nature 407:523-526
20. Saah AJ, Hoover DR, Weng S et al 1998 Association of HLA profiles with early plasma viral load, CD4+ cell count and rate of progression to AIDS following acute HIV-1 infection. Multicenter AIDS Cohort Study. AIDS 12:2107-2113
21. Schmitz JE, Kuroda MJ, Santra S et al 1999 Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283:857-860
22. Thomsen AR, Johansen J, Marker O, Christensen JP 1996 Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice. J Immunol 157:3074-3080
23. Thomsen AR, Nansen A, Christensen JP, Andreasen SO, Marker O 1998 CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus. J Immunol 161:4583-4590
24. Wei XP, Ghosh SK, Taylor ME et al 1995 Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117-122
25. Wodarz D, Nowak MA 1999 Specific therapy regimes could lead to long-term control of HIV. Proc Natl Acad Sci USA 96:14464-14469
26. Wodarz D, May RM, Nowak MA 2000a The role of antigen-independent persistence of memory cytotoxic lymphocytes. Int Immunol 12:467-477
27. Wodarz D, Page KM, Arnaout RA, Thomsen AR, Lifson JD, Nowak MA 2000b A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment. Philos Trans R Soc Lond B Biol Sci 355:329-343