Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF

Nucleic Acids Research

Volumn 32, Issue 2, 2004, Pages 590-597

  Sekimata, Masayuki ^a   Homma, Yoshimi ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOSINE; DNA; GUANINE; METHYL CPG BINDING PROTEIN 2; PROTEIN MIZF; RETINOBLASTOMA PROTEIN; THYMINE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; BIOASSAY; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA SEQUENCE; EPIGENETICS; GENE AMPLIFICATION; GENE DELETION; GENE REPRESSION; GENE SEQUENCE; GENE SILENCING; GENE TARGETING; GENETIC CONSERVATION; GENETIC DATABASE; GENETIC SELECTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SEQUENCE ANALYSIS;

BASE SEQUENCE; BINDING SITES; CARRIER PROTEINS; CELL LINE; CONSENSUS SEQUENCE; DNA; DNA-BINDING PROTEINS; GENE SILENCING; GENES, RETINOBLASTOMA; HUMANS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; REPRESSOR PROTEINS; RESPONSE ELEMENTS; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC; ZINC FINGERS;

EID: 1342306393     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh249     Document Type: Article

References (41)

1. Nan,X., Ng,H.H., Johnson,C.A., Laherty,C.D., Turner,B.M., Eisenman,R.N. and Bird,A. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature, 393, 386-389.
2. Jones,P.L., Veenstra,G.J., Wade,P.A., Vermaak,D., Kass,S.U., Landsberger,N., Strouboulis,J. and Wolffe,A.P. (1998) Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genet., 19, 187-191.
3. Tate,P.H. and Bird,A.P. (1993) Effects of DNA methylation on DNA-binding proteins and gene expression. Curr. Opin. Genet. Dev., 3, 226-231.
4. Ng,H.H., Zhang,Y., Hendrich,B., Johnson,C.A., Turner,B.M., Erdjument-Bromage,H., Tempst,P., Reinberg,D. and Bird,A. (1999) MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nature Genet., 23, 58-61.
5. Nan,X., Campoy,F.J. and Bird,A. (1997) MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell, 88, 471-481.
6. Hassig,C.A., Fleischer,T.C., Billin,A.N., Schreiber,S.L. and Ayer,D.E. (1997) Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell, 89, 341-347.
7. Heinzel,T., Lavinsky,R.M., Mullen,T.M., Soderstrom,M., Laherty,C.D., Torchia,J., Yang,W.M., Brard,G., Ngo,S.D., Davie,J.R. et al. (1997) A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature, 387, 43-48.
8. Feng,Q. and Zhang,Y. (2001) The MeCP1 complex represses transcription through preferential binding, remodeling and deacetylating methylated nucleosomes. Genes Dev., 15, 827-832.
9. Magdinier,F. and Wolffe,A.P. (2001) Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. Proc. Natl Acad. Sci. USA, 98, 4990-4995.
10. El-Osta,A., Kantharidis,P., Zalcberg,J.R. and Wolffe,A.P. (2002) Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Mol. Cell. Biol., 22, 1844-1857.
11. Bakker,J., Lin,X. and Nelson,W.G. (2002) Methyl-CpG binding domain protein 2 represses transcription from hypermethylated π-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells. J. Biol. Chem., 277, 22573-22580.
12. ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. Nucleic Acids Res., 30, 2911-2919.
13. Wade,P.A., Gegonne,A., Jones,P.L., Ballestar,E., Aubry,F. and Wolffe,A.P. (1999) Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nature Genet., 23, 62-66.
14. Zhang,Y., Ng,H.H., Erdjument-Bromage,H., Tempst,P., Bird,A. and Reinberg,D. (1999) Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev., 13, 1924-1935.
15. Bird,A.P. and Wolffe,A.P. (1999) Methylation-induced repression-belts, braces and chromatin. Cell, 99, 451-454.
16. Sekimata,M., Takahashi,A., Murakami-Sekimata,A. and Homma,Y. (2001) Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. J. Biol. Chem., 276, 42632-42638.
17. Klug,A. and Schwabe,J.W. (1995) Protein motifs 5. Zinc fingers. FASEB J., 9, 597-604.
18. Wright,W.E., Binder,M. and Funk,W. (1991) Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site. Mol. Cell. Biol., 11, 4104-4110.
19. Martelli,F., Cenciarelli,C., Santarelli,G., Polikar,B., Felsani,A. and Caruso,M. (1994) MyoD induces retinoblastoma gene expression during myogenic differentiation. Oncogene, 9, 3579-3590.
20. Andrews,N.C. and Faller,D.V. (1991) A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res., 19, 2499.
21. Sakai,T., Ohtani,N., McGee,T.L., Robbins,P.D. and Dryja,T.P. (1991) Oncogenic germ-line mutations in SpI and ATF sites in the human retinoblastoma gene. Nature, 353, 83-86.
22. Savoysky,E., Mizuno,T., Sowa,Y., Watanabe,H., Sawada,J., Nomura,H., Ohsugi,Y., Handa,H. and Sakai,T. (1994) The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family. Oncogene, 9, 1839-1846.
23. Shan,B., Chang,C.Y., Jones,D. and Lee,W.H. (1994) The transcription factor E2F-1 mediates the autoregulation of RB gene expression. Mol. Cell. Biol., 14, 299-309.
24. Sowa,Y., Shiio,Y., Fujita,T., Matsumoto,T., Okuyama,Y., Kato,D., Inoue,J., Sawada,J., Goto,M., Watanabe,H. et al. (1997) Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1. Cancer Res., 57, 3145-3148.
25. Okuyama,Y., Sowa,Y., Fujita,T., Mizuno,T., Nomura,H., Nikaido,T., Endo,T. and Sakai,T. (1996) ATF site of human RB gene promoter is a responsive element of myogenic differentiation. FEBS Lett., 397, 219-224.
26. Prokhortchouk,A., Hendrich,B., Jorgensen,H., Ruzov,A., Wilm,M., Georgiev,G., Bird,A. and Prokhortchouk,E. (2001) The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Genes Dev., 15, 1613-1618.
27. Desjarlais,J.R. and Berg,J.M. (1992) Towards rules relating zinc finger protein sequences and DNA binding site preferences. Proc. Natl Acad. Sci. USA, 89, 7345-7349.
28. Suzuki,M., Gerstein,M. and Yagi,N. (1994) Stereochemical basis of DNA recognition by zinc fingers. Nucleic Acids Res., 22, 3397-3405.
29. Delwel,R., Funabiki,T., Kreider,B.L., Morishita,K. and Ihle,J.N. (1993) Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA. Mol. Cell. Biol., 13, 4291-4300.
30. Campanero,M.R., Armstrong,M.I. and Flemington,E.K. (2000) CpG methylation as a mechanism for the regulation of E2F activity. Proc. Natl Acad. Sci. USA, 97, 6481-6486.
31. Holler,M., Westin,G., Jiricny,J. and Schaffner,W. (1988) Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated. Genes Dev., 2, 1127-1135.
32. Ahringer,J. (2000) NuRD and SIN3 histone deacetylase complexes in development. Trends Genet., 16, 351-536.
33. Hendrich,B. and Bird,A. (1999) Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol. Cell. Biol., 18, 6539-6547.
34. Richon,V.M., Rifkind,R.A. and Marks,P.A. (1992) Expression and phosphorylation of the retinoblastoma protein during induced differentiation of murine erythroleukemia cells. Cell Growth Differ., 3, 413-420.
35. Ohtani-Fujita,N., Fujita,T., Aoike,A., Osifchin,N.E., Robbins,P.D. and Sakai,T. (1993) CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene, 8, 1063-1067.
36. Stirzaker,C., Millar,D.S., Paul,C.L., Warnecke,P.M., Harrison,J., Vincent,P.C., Frommer,M. and Clark,S.J. (1997) Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors. Cancer Res., 57, 2229-2237.
37. Simpson,D.J., Hibberts,N.A., McNicol,A.M., Clayton,R.N. and Farrell,W.E. (2000) Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island. Cancer Res., 60, 1211-1216.
38. Park,K., Choe,J., Osifchin,N.E., Templeton,D.J., Robbins,P.D. and Kim,S.J. (1994) The human retinoblastoma susceptibility gene promoter is positively autoregulated by its own product. J. Biol. Chem., 269, 6083-6088.
39. Lin,X. and Nelson,W.G. (2003) Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells. Cancer Res., 63, 498-504.
40. Moffat,G.J., McLaren,A.W. and Wolf,C.R. (1994) Involvement of Jun and Fos proteins in regulating transcriptional activation of the human Pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells. J. Biol. Chem., 269, 16397-16402.
41. Moffat,G.J., McLaren,A.W. and Wolf,C.R. (1996) Functional characterization of the transcription silencer element located within the human Pi class glutathione S-transferase promoter. J. Biol. Chem., 271, 20740-20747.