Effects of 18 days of bed rest on leg and arm venous properties

Journal of Applied Physiology

Volumn 96, Issue 3, 2004, Pages 840-847

  Bleeker, M W P ^a   De Groot, P C E ^a   Pawelczyk, J A ^b   Hopman, M T E ^a   Levine, B D ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Lower body negative pressure tolerance; Strain gauge plethysmography; Venous compliance; Venous flow resistance

Indexed keywords

ADULT; ARM BLOOD FLOW; ARM BLOOD VESSEL; ARTICLE; BED REST; CAPACITANCE BLOOD VESSEL; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEAD TILTING; HUMAN; HUMAN EXPERIMENT; IMMOBILIZATION; LEG BLOOD FLOW; LEG VEIN; LOWER BODY NEGATIVE PRESSURE; MALE; MICROGRAVITY; NORMAL HUMAN; ORTHOSTATIC DYSREGULATION; ORTHOSTATIC HYPOTENSION; PARAMETER; PRIORITY JOURNAL; VEIN BLOOD FLOW; VEIN COMPLIANCE; VEIN OCCLUSION PLETHYSMOGRAPHY; VEIN RESISTANCE;

ADOLESCENT; ADULT; ARM; BED REST; FEMALE; HUMANS; LEG; LINEAR MODELS; MALE; TIME FACTORS; VASCULAR CAPACITANCE; VENOUS PRESSURE;

EID: 1342283032     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00835.2003     Document Type: Article

References (52)

1. Blomquist G and Stone LH. Cardiovascular adjustments to gravitational stress. In: Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 2, vol. III, chapt. 28, p. 1025-1063.
2. Bonde-Petersen F, Suzuki Y, Kawakubo K, and Gunji A. Effect of 20 days bed rest upon peripheral capillary filtration rate, venous compliance and blood flow in arms and legs. Acta Physiol Scand Suppl 616: 65-69, 1994.
3. Brakkee A and Kuiper JP. Plethysmographic measurement of venous flow resistance in man. Vasa 2: 166-173, 1982.
4. Buckey JC Jr, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE, Gaffney FA, and Blomqvist CG. Orthostatic intolerance after spaceflight. J Appl Physiol 81: 7-18, 1996.
5. Buckey JC, Lane LD, Plath G, Gaffney FA, Baisch F, and Blomqvist CG. Effects of head-down tilt for 10 days on the compliance of the leg. Acta Physiol Scand Suppl 604: 53-59, 1992.
6. Buckey JC, Peshock RM, and Blomqvist CG. Deep venous contribution to hydrostatic blood volume change in the human leg. Am J Cardiol 62: 449-453, 1988.
7. Christ F, Gamble J, Baranov V, Kotov A, Chouker A, Thiel M, Gartside IB, Moser CM, Abicht J, and Messmer K. Changes in microvascular fluid filtration capacity during 120 days of 6° head-down tilt. J Appl Physiol 91: 2517-2522, 2001.
8. Convertino VA. Cardiovascular consequences of bed rest: effect on maximal oxygen uptake. Med Sci Sports Exerc 29: 191-196, 1997.
9. Convertino VA, Bloomfield SA, and Greenleaf JE. An overview of the issues: physiological effects of bed rest and restricted physical activity. Med Sci Sports Exerc 29: 187-190, 1997.
10. Convertino VA, Doerr DF, Flores JF, Hoffler GW, and Buchanan P. Leg size and muscle functions associated with leg compliance. J Appl Physiol 64: 1017-1021, 1988.
11. Convertino VA, Doerr DF, Mathes KL, Stein SL, and Buchanan P. Changes in volume, muscle compartment, and compliance of the lower extremities in man following 30 days of exposure to simulated microgravity. Aviat Space Environ Med 60: 653-658, 1989.
12. Convertino VA, Doerr DF, and Stein SL. Changes in size and compliance of the calf after 30 days of simulated microgravity. J Appl Physiol 66: 1509-1512, 1989.
13. 2 reduction associated with age, gender, and aerobic capacity. Aviat Space Environ Med 57: 17-22, 1986.
14. Dunbar SL, Berkowitz DE, Brooks-Asplund EM, and Shoukas AA. The effects of hindlimb unweighting on the capacitance of rat small mesenteric veins. J Appl Physiol 89: 2073-2077, 2000.
15. Dunbar SL, Tamhidi L, Berkowitz DE, and Shoukas AA. Hindlimb unweighting affects rat vascular capacitance function. Am J Physiol Heart Circ Physiol 281: H1170-H1177, 2001.
16. Engelke KA, Doerr DF, Crandall CG, and Convertino VA. Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity. Am J Physiol Regul Integr Comp Physiol 271: R837-R847, 1996.
17. Fortney SM, Turner C, Steinmann L, Driscoll T, and Alfrey C. Blood volume responses of men and women to bed rest. J Clin Pharmacol 34: 434-439, 1994.
18. Freeman R, Lirofonis V, Farquhar WB, and Risk M. Limb venous compliance in patients with idiopathic orthostatic intolerance and postural tachycardia. J Appl Physiol 93: 636-644, 2002.
19. Frieden RA, Ahn JH, Pineda HD, Minutoli F, and Whelan E. Venous plethysmography values in patients with spinal cord injury. Arch Phys Med Rehabil 68: 427-429, 1987.
20. Fu Q, Iwase S, Kamiya A, Michikami D, Niimi Y, and Mano T. Regulation of the venous capacitance during microgravity. J Gravit Physiol 7: P19-P22, 2000.
21. Greenleaf JE and Kozlowski S. Reduction in peak oxygen uptake after prolonged bed rest. Med Sci Sports Exerc 14: 477-480, 1982.
22. Halliwill JR, Lawler LA, Eickhoff TJ, Joyner MJ, and Mulvagh SL. Reflex responses to regional venous pooling during lower body negative pressure in humans. J Appl Physiol 84: 454-458, 1998.
23. Halliwill JR, Minson CT, and Joyner MJ. Measurement of limb venous compliance in humans: technical considerations and physiological findings. J Appl Physiol 87: 1555-1563, 1999.
24. Hasser EM and Moffitt JA. Regulation of sympathetic nervous system function after cardiovascular deconditioning. Ann NY Acad Sci 940: 454-468, 2001.
25. Hopman MT, Nommensen E, van Asten WN, Oeseburg B, and Binkhorst RA. Properties of the venous vascular system in the lower extremities of individuals with paraplegia. Paraplegia 32: 810-816, 1994.
26. Kamiya A, Iwase S, Michikami D, Fu Q, Mano T, Kitaichi K, and Takagi K. Increased vasomotor sympathetic nerve activity and decreased plasma nitric oxide release after head-down bed rest in humans: disappearance of correlation between vasoconstrictor and vasodilator. Neurosci Lett 281: 21-24, 2000.
27. Lawler LA, Halliwill JR, Summer JM, Joyner MJ, and Mulvagh SL. Leg mass and lower body negative pressure tolerance in men and women. J Appl Physiol 85: 1471-1475, 1998.
28. Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Diedrich A, Biaggioni I, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC Jr, Cooke WH, Baisch FJ, Eckberg DL, and Blomqvist CG. Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight. J Physiol 538: 331-340, 2002.
29. Levine BD, Zuckerman JH, and Pawelczyk JA. Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance. Circulation 96: 517-525, 1997.
30. Louisy F, Berry P, Marini JF, Guell A, and Guezennec CY. Characteristics of the venous hemodynamics of the leg under simulated weightlessness: effects of physical exercise as countermeasure. Aviat Space Environ Med 66: 542-549, 1995.
31. Louisy F, Gaudin C, Oppert JM, Guell A, and Guezennec CY. Haemodynamics of leg veins during a 30-days-6 degrees head-down bedrest with and without lower body negative pressure. Eur J Appl Physiol 61: 349-355, 1990.
32. Louisy F, Jouanin JC, and Guezennec CY. Filling and emptying characteristics of lower limb venous network in athletes. Study by postural plethysmography. Int J Sports Med 18: 26-29, 1997.
33. Louisy F, Schroiff P, and Guell A. Changes in leg vein filling and emptying characteristics and leg volumes during long-term head-down bed rest. J Appl Physiol 82: 1726-1733, 1997.
34. Mano T, Iwase S, and Kamiya A. Sympathetic nerve responses in humans to short and long term simulation of microgravity. J Gravit Physiol 5: 93-96, 1998.
35. Melchior FM and Fortney SM. Orthostatic intolerance during a 13-day bed rest does not result from increased leg compliance. J Appl Physiol 74: 286-292, 1993.
36. Monahan KD, Dinenno FA, Seals DR, and Halliwill JR. Smaller age-associated reductions in leg venous compliance in endurance exercise-trained men. Am J Physiol Heart Circ Physiol 281: H1267-H1273, 2001.
37. Pang CC. Autonomic control of the venous system in health and disease: effects of drugs. Pharmacol Ther 90: 179-230, 2001.
38. Pawelczyk JA and Levine BD. Heterogeneous responses of human limbs to infused adrenergic agonists: a gravitational effect? J Appl Physiol 92: 2105-2113, 2002.
39. Pawelczyk JA, Zuckerman JH, Blomqvist CG, and Levine BD. Regulation of muscle sympathetic nerve activity after bed rest deconditioning. Am J Physiol Heart Circ Physiol 280: H2230-H2239, 2001.
40. Pointel JP, Gin H, Drouin P, Vernhes G, and Debry G. Venous plethysmography: measuring techniques and normal values. Angiology 32: 145-154, 1981.
41. Risk MR, Lirofonis V, Armentano RL, and Freeman R. A biphasic model of limb venous compliance: a comparison with linear and exponential models. J Appl Physiol 95: 1207-1215, 2003.
42. Rothe CF. Physiology of venous return. An unappreciated boost to the heart. Arch Intern Med 146: 977-982, 1986.
43. 1-adrenoceptors in rat vena cava. J Appl Physiol 78: 1882-1888, 1995.
44. Shoemaker JK, Hogeman CS, Leuenberger UA, Herr MD, Gray K, Silber DH, and Sinoway LI. Sympathetic discharge and vascular resistance after bed rest. J Appl Physiol 84: 612-617, 1998.
45. Shoemaker JK, Hogeman CS, and Sinoway LI. Contributions of MSNA and stroke volume to orthostatic intolerance following bed rest. Am J Physiol Regul Integr Comp Physiol 277: R1084-R1090, 1999.
46. Siri W. Body composition from fluid spaces and density: analysis of methods. Nutrition 9: 480-491, 1993.
47. Thornton WE, Hedge V, Coleman E, Uri JJ, and Moore TP. Changes in leg volume during microgravity simulation. Aviat Space Environ Med 63: 789-794, 1992.
48. Thornton WE, Moore TP, and Pool SL. Fluid shifts in weightlessness. Aviat Space Environ Med 58: A86-A90, 1987.
49. Watenpaugh DE, Buckey JC, Lane LD, Gaffney FA, Levine BD, Moore WE, Wright SJ, and Blomqvist CG. Effects of spaceflight on human calf hemodynamics. J Appl Physiol 90: 1552-1558, 2001.
50. Wecht JM, de Meersman RE, Weir JP, Bauman WA, and Grimm DR. Effects of autonomic disruption and inactivity on venous vascular function. Am J Physiol Heart Circ Physiol 278: H515-H520, 2000.
51. Whitney R. The measurement of volume changes in human limbs. J Physiol 121: 1-27, 1953.
52. Wilson TE, Shibasaki M, Cui J, Levine BD, and Crandall CG. Effects of 14 days of head-down tilt bed rest on cutaneous vasoconstrictor responses in humans. J Appl Physiol 94: 2113-2118, 2003.