K-ras and B-raf gene mutations are not associated with gastrin- and CCK2-receptor mRNA expression in human colorectal tumour tissues

European Journal of Clinical Investigation

Volumn 34, Issue 2, 2004, Pages 100-106

  Monstein, H J ^a,b,d   Fransen K ^b   Dimberg, J ^c   Soderkvist P ^b,c  

^a University Hospital   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c JÖNKÖPING UNIVERSITY   (Sweden)

^d LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

B raf gene mutation; CCK2 receptor mRNA; Colorectal cancer; Gastrin mRNA; Gene expression; K ras gene mutation

Indexed keywords

CHOLECYSTOKININ B RECEPTOR; GASTRIN; K RAS PROTEIN; MESSENGER RNA; RAF PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLORECTAL TUMOR; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR BIOPSY;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GASTRINS; GENES, RAS; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; NEOPLASM STAGING; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; RECEPTOR, CHOLECYSTOKININ B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM;

EID: 1342267520     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2004.01296.x     Document Type: Article

References (46)

1. Calvert PM, Frucht H. The genetics of colorectal cancer. Ann Intern Med 2002;137:603-12.
2. Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Raf/Ras oncogenes and mismatch-repair status. Nature 2002;418:934.
3. Campell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ. Increasing complexity of Ras signalling. Oncogene 1998;17:1395-413.
4. Hagman C, Rapp UR. Isotype-specific functions of Raf kinases. Exp Cell Res 1999;253:34-46.
5. Peyssonnaux C, Eychéne A. The Raf/MEK/ERK pathway, new concepts of activation. Biol Cell 2001;93:53-62.
6. Houlston RS. What we could do now: molecular pathology of colorectal cancer. J Clin Pathol: Mol Pathol 2001;54:206-14.
7. Davis H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-54.
8. Wank SA. Cholecystokinin receptors. Am J Physiol 1995;269:G628-48.
9. Shulkes A, Baldwin GS. Biology of gut cholecystokinin and gastrin receptors. Clin Exp Pharmacol Physiol 1997;24:209-16.
10. Reubi JC, Schaer JC, Waser B. Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors. Cancer Res 1997;57:1377-86.
11. Miyake A. A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon. Biochem Biophys Res Commun 1995;208:230-7.
12. McWilliams DF, Watson SA, Crosbee DM, Michaeli D, Seth R. Coexpression of gastrin and gastrin receptors in gastrointestinal tumour cell lines. Gut 1998;42:795-8.
13. Rozengurt E, Walsh JH. Gastrin, CCK, signaling and cancer. Ann Rev Physiol 2001;63:49-76.
14. Van Solinge WW, Rehfeld JF. Co-transcription of the gastrin and cholecystokinin genes with selective translation of gastrin mRNA in a human gastric-carcinoma cell line. FEBS Lett 1992;308:47-50.
15. Seva C, Dickinson CJ, Yamada T. Growth promoting effects of glycine-extended progastrin. Science 1994;265:410-2.
16. Watson SA. Gastrin antagonists and gastrointestinal tumours. Exp Opin Invest Drugs 1995;4:1253-66.
17. Monstein H-J, Nylander AG, Salehi A, Chen D, Lundquist I, Håkanson R. Cholecystokinin-A and cholecystokinin-B/gastrin receptor mRNA expression in the gastrointestinal tract and pancreas of rat and man. A polymerase chain reaction study. Scand J Gastroenterol 1996;31:383-90.
18. Hoosein NM, Kiener PA, Curry RC, Rovati LC, McGilbra DK, Brattin MG. Antiproliverative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines. Cancer Res 1998;48:7179-83.
19. Koh TJ, Chen D. Gastrin as a growth factor in the gastrointestinal tract. Reg Pept 2000;93:37-44.
20. Godley JM, Brand S. Regulation of the gastrin promoter by epidermal growth factor and neuropeptides. Proc Natl Acad Sci USA 1989;86:3036-40.
21. Tillotson LG, Wang TC, Brand SJ. Activation of gastrin transcription in pancreatic insulinoma cells by a CACC promoter element and a 70-kDa sequence-specific DNA-binding protein. J Biol Chem 1994;269:2234-40.
22. Sasaoka T, Langlois WJ, Leitner JW, Draznin B, Olefsky JM. The signaling pathway coupling epidermal growth factor receptors to activation of p21 ras. J Biol Chem 1994;269:32621-5.
23. McCarthy SA, Samuels SM, Pritchard CA, Abraham JA, McMahon M. Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. Genes Dev 1995;9:1953-64.
24. Todisco A. Molecular mechanisms for the growth factor action of gastrin. J Gastroenterol 2000;35 (Suppl. XIII):57-64.
25. Williams JA, Sans MD, Tashiro M, Schäfer C, Bragado MJ, Dabrowski A. Cholecystokinin activates a variety of intracellular signal transduction mechanisms in rodent pancreatic acinar cells. Pharmacol Toxicol 2002;91:297-303.
26. Nakata H, Wang S-L, Chung DC, Westwick JK. Oncogenic Ras induces gastrin gene expression in colon cancer. Gastroenterol 1998;115:1144-53.
27. Fransén K, Klintenäs M, Österström A, Dimberg J, Monstein H-J, Söderkvist P. Mutation analysis of the BRAF, ARAF and Raf-1 genes in human colorectal adenocarcinomas. Carcinogen 2004, in press.
28. Orita M, Hiroyuki I, Kanazawa H, Hayashi K, Sekiya T. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci USA 1989;86:2766-70.
29. Monstein H-J, Ohlsson B, Axelson J. Differential expression of gastrin, cholecystokinin-A and cholecystokinin-B receptor mRNA in human pancreatic cancer cell lines. Scand J Gastroenterol 2001;36:738-43.
30. Pisegna JR, de Weerth A, Huppi K, Wank SA. Molecular cloning of the human brain and gastric cholecystokinin receptor, structure, functional expression and chromosomal localization. Biochem Biophys Res Commun 1992;189:296-303.
31. Monstein H-J, Nilsson I, Ellnebo-Svedlund K, Svensson SPS. Cloning and characterization of 5′-end alternatively spliced human cholecystokinin-B receptor mRNAs. Recept Channels 1998;6:165-77.
32. Van Solinge WW, Nielsen FC, Friis-Hansen L, Falkmer U, Rehfeld JF. Expression but incomplete maturation of progastrin in colorectal carcinomas. Gastroenterol 1993;104:1099-107.
33. Seva C, Dickinson Ch, Yamada T. Growth promoting effects of glycine extended progastrin. Science 1994;265:410-2.
34. Bold JR, Ishizuka J, Townsend CM, Thompson JC. Gastrin stimulates growth of human colon cancer cells via a receptor other than CCK-A or CCK-B. Biochem Biophys Res Commun 1994;202:2086-92.
35. Imdahl A, Mantamadiotis T, Eggstein S, Farthmann EH, Baldwin GS. Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas. J Cancer Res Clin Oncol 1995;121:661-6.
36. Singh P, Owlia A, Varro A, Dai B, Rajaraman S, Wood T. Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells. Cancer Res 1996;56:4111-5.
37. Kermorgant S, Lehy T. Glycine extended gastrin promotes the invasiveness of human colon cancer cells. Biochem Biophys Res Commun 2001;285:136-41.
38. Singh P, Dai B, Wu H, Owlia A. Role of autocrine and endocrine gastrin-like peptides in colonic carcinogenesis. Cur Opin Gastroenterol 2000;16:68-77.
39. Schmitz F, Otte J-M, Stechele HU, Reinmann B, Banasiewicz T, Fölsch UR et al. CCK-B/gastrin receptors in human colorectal cancer. Eur J Clin Invest 2001;31:812-20.
40. Watson SA, Michaeli D, Smith A, McWilliams DF. Quantification of gastrin and CCKB/gastrin receptor expression during adenoma carcinoma sequence in the colon. Gastroenterol 2000;118:A1607.
41. Iwata N, Murayama T, Matsumori Y, Ito M, Nagata N, Taniguchi T et al. Autocrine loop through cholecystokinin-B/gastrin receptors involved in growth of human leukemia cells. Blood 1996;88:2683-9.
42. Schmitz F, Schrader H, Otte J-M, Schmitz H, Stüber E, Herzig K-E et al. Identification of CCK-B/gastrin receptor splice variants in human peripheral blood mononuclear cells. Reg Pept 2001;101:25-33.
43. Hellmich MR, Rui X-L, Hellmich HL, Declan Fleming RY, Mark Evers B, Townsend CM. Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth. J Biol Chem 2000;275:32122-8.
44. Smith JP, Verderame MF, McLaughlin P, Martenis M, Ballard E, Zagon IS. Characterization of the CCK-C (cancer) receptor in human pancreatic cancer. Int J Mol Med 2002;10:689-94.
45. Wiborg O, Berglund L, Boel E, Norris F, Rehfeld JF, Marcker KA et al. Structure of a human gastrin gene. Proc Natl Acad Sci USA 1984;81:1067-9.
46. Tiveljung A, Backström J, Forsum U, Monstein H-J. Broad-range PCR amplification and DNA sequence analysis reveals variable motifs in 16S rRNA genes of Mobiluncus species. APMIS 1995;103:755-63.