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Volumn 33, Issue 5, 2003, Pages 688-695

Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma

Author keywords

Allergy; Cytokines; In vivo animal models; Inflammation; STAT6

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 13; INTERLEUKIN 14; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; OVALBUMIN; STAT6 PROTEIN;

EID: 0038579646     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2003.01647.x     Document Type: Article
Times cited : (48)

References (32)
  • 1
    • 0032725001 scopus 로고    scopus 로고
    • The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: More similarities than differences
    • Humbert M, Menz G, Ying S et al. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today 1999; 20:528-33.
    • (1999) Immunol Today , vol.20 , pp. 528-533
    • Humbert, M.1    Menz, G.2    Ying, S.3
  • 3
    • 15144358845 scopus 로고    scopus 로고
    • Effect of inhaled interleukin-5 on airway hyperreactivity and eosinophilia in asthmatics
    • Shi HZ, Xiao CQ, Zhong D et al. Effect of inhaled interleukin-5 on airway hyperreactivity and eosinophilia in asthmatics. Am J Respir Crit Care Med 1998; 157:204-9.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 204-209
    • Shi, H.Z.1    Xiao, C.Q.2    Zhong, D.3
  • 4
    • 0035206065 scopus 로고    scopus 로고
    • Understanding airway wall remodeling in asthma: A basis for improvements in therapy?
    • Kumar RK. Understanding airway wall remodeling in asthma: a basis for improvements in therapy? Pharmacol Ther 2001; 91:93-104.
    • (2001) Pharmacol Ther , vol.91 , pp. 93-104
    • Kumar, R.K.1
  • 5
    • 0036729230 scopus 로고    scopus 로고
    • Modeling allergic asthma in mice: Pitfalls and opportunities
    • Kumar RK, Foster PS. Modeling allergic asthma in mice: pitfalls and opportunities. Am J Respir Cell Mol Biol 2002; 27:267-72.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 267-272
    • Kumar, R.K.1    Foster, P.S.2
  • 6
    • 0031781163 scopus 로고    scopus 로고
    • An improved murine model of asthma: Selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen
    • Temelkovski J, Hogan SP, Shepherd DP, Foster PS, Kumar RK. An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax 1998; 53:849-56.
    • (1998) Thorax , vol.53 , pp. 849-856
    • Temelkovski, J.1    Hogan, S.P.2    Shepherd, D.P.3    Foster, P.S.4    Kumar, R.K.5
  • 7
    • 0034079382 scopus 로고    scopus 로고
    • Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma
    • Foster PS, Ming Y, Matthei KI, Young IG, Temelkovski J, Kumar RK. Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma. Lab Invest 2000; 80:655-62.
    • (2000) Lab Invest , vol.80 , pp. 655-662
    • Foster, P.S.1    Ming, Y.2    Matthei, K.I.3    Young, I.G.4    Temelkovski, J.5    Kumar, R.K.6
  • 8
    • 0035987319 scopus 로고    scopus 로고
    • Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma
    • Kumar RK, Herbert C, Yang M, Koskinen AML, McKenzie ANJ, Foster PS. Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma. Clin Exp Allergy 2002; 32:1104-11.
    • (2002) Clin Exp Allergy , vol.32 , pp. 1104-1111
    • Kumar, R.K.1    Herbert, C.2    Yang, M.3    Koskinen, A.M.L.4    McKenzie, A.N.J.5    Foster, P.S.6
  • 9
    • 0036223582 scopus 로고    scopus 로고
    • CD4+ T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma
    • Foster PS, Yang M, Herbert C, Kumar RK. CD4+ T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma. Lab Invest 2002; 82:455-62.
    • (2002) Lab Invest , vol.82 , pp. 455-462
    • Foster, P.S.1    Yang, M.2    Herbert, C.3    Kumar, R.K.4
  • 10
    • 0036229742 scopus 로고    scopus 로고
    • Eotaxin expression by epithelial cells and plasma cells in chronic asthma
    • Kumar RK, Thomas PS, Seetoo DQ et al. Eotaxin expression by epithelial cells and plasma cells in chronic asthma. Lab Invest 2002; 82:495-504.
    • (2002) Lab Invest , vol.82 , pp. 495-504
    • Kumar, R.K.1    Thomas, P.S.2    Seetoo, D.Q.3
  • 11
    • 0030949167 scopus 로고    scopus 로고
    • STAT6: Its role in interleukin 4-mediated biological functions
    • Takeda K, Kishimoto T, Akira S. STAT6: its role in interleukin 4-mediated biological functions. J Mol Med 1997; 75:317-26.
    • (1997) J Mol Med , vol.75 , pp. 317-326
    • Takeda, K.1    Kishimoto, T.2    Akira, S.3
  • 12
    • 0034755167 scopus 로고    scopus 로고
    • Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT6 independently of IL-5 and eotaxin
    • Yang M, Hogan SP, Henry PJ et al. Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol 2001; 25:522-30.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 522-530
    • Yang, M.1    Hogan, S.P.2    Henry, P.J.3
  • 13
    • 0030800586 scopus 로고    scopus 로고
    • Non-invasive measurement of airway responsiveness in allergic mice using barometric plethysmography
    • Hamelmann E, Schwarze J, Takeda K et al. Non-invasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997; 156:766-75.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 766-775
    • Hamelmann, E.1    Schwarze, J.2    Takeda, K.3
  • 14
    • 0031918920 scopus 로고    scopus 로고
    • Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyper-reactivity, and lung damage in mice
    • Hogan SP, Koskinen A, Matthaei KI, Young IG, Foster PS. Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyper-reactivity, and lung damage in mice. Am J Respir Crit Care Med 1998; 157:210-8.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 210-218
    • Hogan, S.P.1    Koskinen, A.2    Matthaei, K.I.3    Young, I.G.4    Foster, P.S.5
  • 16
    • 0032536837 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription factor 6 (STAT6)-deficient mice are protected from antigen-induced airway hyper-responsiveness and mucus production
    • Kuperman D, Schofield B, Wills-Karp M, Grusby MJ. Signal transducer and activator of transcription factor 6 (STAT6)-deficient mice are protected from antigen-induced airway hyper-responsiveness and mucus production. J Exp Med 1998; 187:939-48.
    • (1998) J Exp Med , vol.187 , pp. 939-948
    • Kuperman, D.1    Schofield, B.2    Wills-Karp, M.3    Grusby, M.J.4
  • 17
    • 0032482159 scopus 로고    scopus 로고
    • Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT) 6-deficient mice
    • Akimoto T, Numata F, Tamura M et al. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT) 6-deficient mice. J Exp Med 1998; 187:1537-42.
    • (1998) J Exp Med , vol.187 , pp. 1537-1542
    • Akimoto, T.1    Numata, F.2    Tamura, M.3
  • 18
    • 0032926518 scopus 로고    scopus 로고
    • STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells
    • Miyata S, Matsuyama T, Kodama T et al. STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells. Clin Exp Allergy 1999; 29:114-23.
    • (1999) Clin Exp Allergy , vol.29 , pp. 114-123
    • Miyata, S.1    Matsuyama, T.2    Kodama, T.3
  • 19
    • 0032828226 scopus 로고    scopus 로고
    • The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyper-responsiveness is overcome by interleukin-5
    • Tomkinson A, Kanehiro A, Rabinovitch N, Joetham A, Cieslewicz G, Gelfand EW. The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyper-responsiveness is overcome by interleukin-5. Am J Respir Crit Care Med 1999; 160:1283-91.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1283-1291
    • Tomkinson, A.1    Kanehiro, A.2    Rabinovitch, N.3    Joetham, A.4    Cieslewicz, G.5    Gelfand, E.W.6
  • 20
    • 0033861279 scopus 로고    scopus 로고
    • Abrogation of lung inflammation in sensitized STAT6-deficient mice is dependent on the allergen inhalation procedure
    • Trifilieff A, El-Hasim A, Corteling R, Owen CE. Abrogation of lung inflammation in sensitized STAT6-deficient mice is dependent on the allergen inhalation procedure. Br J Pharmacol 2000; 130:1581-8.
    • (2000) Br J Pharmacol , vol.130 , pp. 1581-1588
    • Trifilieff, A.1    El-Hasim, A.2    Corteling, R.3    Owen, C.E.4
  • 21
    • 0035821221 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 trafficking in allergic pulmonary inflammation
    • Mathew A, MacLean JA, DeHaan E, Tager AM, Green FH, Luster AD. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 trafficking in allergic pulmonary inflammation. J Exp Med 2001; 193:1087-96.
    • (2001) J Exp Med , vol.193 , pp. 1087-1096
    • Mathew, A.1    MacLean, J.A.2    DeHaan, E.3    Tager, A.M.4    Green, F.H.5    Luster, A.D.6
  • 22
    • 0036256471 scopus 로고    scopus 로고
    • Adoptive transfer of T cells induces airway hyperresponsiveness independently of airway eosinophilia but in a signal transducer and activator of transcription 6-dependent manner
    • Tomkinson A, Duez C, Lahn M, Gelfand EW. Adoptive transfer of T cells induces airway hyperresponsiveness independently of airway eosinophilia but in a signal transducer and activator of transcription 6-dependent manner. J Allergy Clin Immunol 2002; 109:810-6.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 810-816
    • Tomkinson, A.1    Duez, C.2    Lahn, M.3    Gelfand, E.W.4
  • 23
    • 0036174529 scopus 로고    scopus 로고
    • STAT6-deficient mice develop airway hyper-responsiveness and peribronchial fibrosis during chronic fungal asthma
    • Blease K, Schuh JM, Jakubzick C et al. STAT6-deficient mice develop airway hyper-responsiveness and peribronchial fibrosis during chronic fungal asthma. Am J Pathol 2002; 160:481-90.
    • (2002) Am J Pathol , vol.160 , pp. 481-490
    • Blease, K.1    Schuh, J.M.2    Jakubzick, C.3
  • 24
    • 0025216937 scopus 로고
    • Lymphokine control of in vivo immunoglobulin isotype selection
    • Finkelman FD, Holmes J, Katona IM et al. Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 1990; 8:303-33.
    • (1990) Annu Rev Immunol , vol.8 , pp. 303-333
    • Finkelman, F.D.1    Holmes, J.2    Katona, I.M.3
  • 25
    • 0031957991 scopus 로고    scopus 로고
    • Expression of growth factors and remodelling of the airway wall in bronchial asthma
    • Hoshino M, Nakamura Y, Sim JJ. Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax 1998; 53:21-7.
    • (1998) Thorax , vol.53 , pp. 21-27
    • Hoshino, M.1    Nakamura, Y.2    Sim, J.J.3
  • 26
    • 0032826640 scopus 로고    scopus 로고
    • Asymptomatic airway hyper-responsiveness, relationships with airway inflammation and remodelling
    • Laprise C, Laviolette M, Boutet M, Boulet LP. Asymptomatic airway hyper-responsiveness, relationships with airway inflammation and remodelling. Eur Respir J 1999; 14:63-73.
    • (1999) Eur Respir J , vol.14 , pp. 63-73
    • Laprise, C.1    Laviolette, M.2    Boutet, M.3    Boulet, L.P.4
  • 27
    • 0032945548 scopus 로고    scopus 로고
    • Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
    • Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999; 103:175-83.
    • (1999) J Clin Invest , vol.103 , pp. 175-183
    • Hansen, G.1    Berry, G.2    DeKruyff, R.H.3    Umetsu, D.T.4
  • 28
    • 0035424185 scopus 로고    scopus 로고
    • IL-13 induces airways hyperreactivity independently of the IL-4Rα chain in the allergic lung
    • Mattes J, Yang M, Siqueira A et al. IL-13 induces airways hyperreactivity independently of the IL-4Rα chain in the allergic lung. J Immunol 2001; 167:1683-92.
    • (2001) J Immunol , vol.167 , pp. 1683-1692
    • Mattes, J.1    Yang, M.2    Siqueira, A.3
  • 29
    • 0031093680 scopus 로고    scopus 로고
    • Development of airway hyper-responsiveness is dependent on interferon-γ and independent of eosinophil infiltration
    • Hessel EM, van Oosterhout AJM, van Ark I et al. Development of airway hyper-responsiveness is dependent on interferon-γ and independent of eosinophil infiltration. Am J Respir Cell Mol Biol 1997; 16:325-34.
    • (1997) Am J Respir Cell Mol Biol , vol.16 , pp. 325-334
    • Hessel, E.M.1    Van Oosterhout, A.J.M.2    Van Ark, I.3
  • 30
    • 0032711223 scopus 로고    scopus 로고
    • Preferential role for NF-κB/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo
    • Aronica MA, Mora AL, Mitchell DB et al. Preferential role for NF-κB/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J Immunol 1999; 163:5116-24.
    • (1999) J Immunol , vol.163 , pp. 5116-5124
    • Aronica, M.A.1    Mora, A.L.2    Mitchell, D.B.3
  • 31
    • 0035425244 scopus 로고    scopus 로고
    • Administration of pentoxifylline during allergen sensitization dissociates pulmonary allergic inflammation from airway hyper-responsiveness
    • Fleming CM, He H, Ciota A, Perkins D, Finn PW. Administration of pentoxifylline during allergen sensitization dissociates pulmonary allergic inflammation from airway hyper-responsiveness. J Immunol 2001; 167:1703-11.
    • (2001) J Immunol , vol.167 , pp. 1703-1711
    • Fleming, C.M.1    He, H.2    Ciota, A.3    Perkins, D.4    Finn, P.W.5
  • 32
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, ten Brinke A, Khan J et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000; 356:2144-8.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    Ten Brinke, A.2    Khan, J.3


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