Biologically active oligodeoxyribonucleotides. Part 11: The least phosphate-modification of quadruplex-forming hexadeoxyribonucleotide TGGGAG, bearing 3'- and 5'-end-modification, with anti-HIV-1 activity

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 12, 1998, Pages 2469-2475

  Koizumi, Makoto ^a   Koga, Rika ^a   Hotoda, Hitoshi ^a   Ohmine, Toshinori ^a   Furukawa, Hidehiko ^a   Agatsuma, Toshinori ^a   Nishigaki, Takashi ^a   Abe, Koji ^a   Kosaka, Toshiyuki ^a   Tsutsumi, Shinya ^a   Sone, Junko ^a   Kaneko, Masakatsu ^a   Kimura, Satoshi ^b,c   Shimada, Kaoru ^b,d  

^a DAIICHI SANKYO CO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^d Tokyo Senbai Hospital   (Japan)

Author keywords

2 Hydroxyethylphosphate; 3,4 Dibenzyloxybenzyl; Aptamer; Phosphorothioate; Stability

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; OLIGODEOXYRIBONUCLEOTIDE; R 95288; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 13044297059     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)80021-7     Document Type: Article

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