-
1
-
-
0025737742
-
Design of enzyme inhibitors using iterative protein crystallographic analysis
-
Appelt, K., R. J. Bacquet, C. Bartlett, C. L. J. Booth, S. T. Freer, M. M. Fuhry, M. R. Gehring, S. M. Herrmann, E. F. Howland, C. A. Janson, T. R. Jones, C. C. Kan, V. Kathardekar, K. K. Lewis, G. P. Marzoni, D. A. Mathews, C. Mohr, E. W. Moomaw, C. A. Morse, S. J. Oatley, R. C. Ogden, M. R. Reddy, S. H. Reich, W. S. Schoettlin, W. W. Smith, M. D. Varney, J. E. Villafranca, R. W. Ward, S. Webber, S. E. Webber, K. M. Welsh, and J. White. 1991. Design of enzyme inhibitors using iterative protein crystallographic analysis. J. Med. Chem. 34:1925-1928
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1925-1928
-
-
Appelt, K.1
Bacquet, R.J.2
Bartlett, C.3
Booth, C.L.J.4
Freer, S.T.5
Fuhry, M.M.6
Gehring, M.R.7
Herrmann, S.M.8
Howland, E.F.9
Janson, C.A.10
Jones, T.R.11
Kan, C.C.12
Kathardekar, V.13
Lewis, K.K.14
Marzoni, G.P.15
Mathews, D.A.16
Mohr, C.17
Moomaw, E.W.18
Morse, C.A.19
Oatley, S.J.20
Ogden, R.C.21
Reddy, M.R.22
Reich, S.H.23
Schoettlin, W.S.24
Smith, W.W.25
Varney, M.D.26
Villafranca, J.E.27
Ward, R.W.28
Webber, S.29
Webber, S.E.30
Welsh, K.M.31
White, J.32
more..
-
2
-
-
0344867119
-
Mutations in HIV protease conferring resistance to inhibitor L-735,524
-
abstr. 187
-
Condra, J. H., W. A. Schleif, O. M. Blahy, L. J. Gabryelski, D. J. Graham, J. C. Quintero, A. Rhodes, H. L. Robbins, E. Roth, M. Shivaprakash, P. L. Titus, T. Yang, and E. A. Emini. 1995. Mutations in HIV protease conferring resistance to inhibitor L-735,524, abstr. 187, p. 88. In Proceedings of the 2nd National Conference on Human Retroviruses and Related Infections
-
(1995)
Proceedings of the 2nd National Conference on Human Retroviruses and Related Infections
, pp. 88
-
-
Condra, J.H.1
Schleif, W.A.2
Blahy, O.M.3
Gabryelski, L.J.4
Graham, D.J.5
Quintero, J.C.6
Rhodes, A.7
Robbins, H.L.8
Roth, E.9
Shivaprakash, M.10
Titus, P.L.11
Yang, T.12
Emini, E.A.13
-
3
-
-
0025221948
-
Human immunodeficiency virus protease. target for AIDS therapy
-
Debouck, C., and B. W. Metcalf. 1990. Human immunodeficiency virus protease. target for AIDS therapy. Drug Dev. Res. 21:1-17.
-
(1990)
Drug Dev. Res.
, vol.21
, pp. 1-17
-
-
Debouck, C.1
Metcalf, B.W.2
-
4
-
-
0004061014
-
-
Marcel Dekker, Inc., New York
-
Gibaldi, M., and D. Perrier. 1982. Pharmacokinetics, 2nd ed. Marcel Dekker, Inc., New York
-
(1982)
Pharmacokinetics, 2nd Ed.
-
-
Gibaldi, M.1
Perrier, D.2
-
5
-
-
0028874048
-
Rapid Turnover of plasma virons and CD4 lymphocytes in HIV-1 infection
-
Ho, D., A. V. Neumann, A. S. Perelson, W. Chen, J. M. Leonard, and M. Markowitz. 1995. Rapid Turnover of plasma virons and CD4 lymphocytes in HIV-1 infection Nature (London) 373:123-126.
-
(1995)
Nature (London)
, vol.373
, pp. 123-126
-
-
Ho, D.1
Neumann, A.V.2
Perelson, A.S.3
Chen, W.4
Leonard, J.M.5
Markowitz, M.6
-
6
-
-
34347367934
-
Evaluation of the antiviral activity of orally administered ABT-538, an inhibitor of HIV-1 protease
-
abstr. 185
-
Markowitz, M., L. Jalil, A. Hurley, C. Farthing, Y. Cao, M. S. Saag, W. Powderly, J. Valdes, J. Leonard, and D. D. Ho. 1995. Evaluation of the antiviral activity of orally administered ABT-538, an inhibitor of HIV-1 protease, abstr. 185, p 88 In Proceedings of the 2nd National Conference on Human Retroviruses and Related Infections.
-
(1995)
Proceedings of the 2nd National Conference on Human Retroviruses and Related Infections
, pp. 88
-
-
Markowitz, M.1
Jalil, L.2
Hurley, A.3
Farthing, C.4
Cao, Y.5
Saag, M.S.6
Powderly, W.7
Valdes, J.8
Leonard, J.9
Ho, D.D.10
-
7
-
-
0008477577
-
3
-
abstr 183
-
3, abstr 183, p. 88. In Proceedings of the 2nd National Conference on Human Retroviruses and Related Infections
-
(1995)
Proceedings of the 2nd National Conference on Human Retroviruses and Related Infections
, pp. 88
-
-
Mellors, J.1
Steigbigel, R.2
Gulick, R.3
Frank, I.4
Berry, P.5
McMahon, D.6
Fuhrer, J.7
Farthing, C.8
Hildebrand, C.9
Schleif, W.10
Condra, J.11
Nessly, M.12
Calandra, G.13
Emini, E.14
Chodakewitz, J.15
-
8
-
-
0025779083
-
Target therapy of human immunodeficiency virus-related disease
-
Mitsuya, H., R. Yarchoan, S. Kageyama, and S. Broder. 1990. Target therapy of human immunodeficiency virus-related disease FASEB J 5:2369-2381.
-
(1990)
FASEB J
, vol.5
, pp. 2369-2381
-
-
Mitsuya, H.1
Yarchoan, R.2
Kageyama, S.3
Broder, S.4
-
9
-
-
0027538456
-
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
-
Pantaleo, G., C. Graziosi, J. F. Demarest, L. Butini, M. Montroni, C. H. Fox, J. M. Orenstein, D. P. Kotler, and A. S. Fauci. 1993. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature (London) 362:355-358.
-
(1993)
Nature (London)
, vol.362
, pp. 355-358
-
-
Pantaleo, G.1
Graziosi, C.2
Demarest, J.F.3
Butini, L.4
Montroni, M.5
Fox, C.H.6
Orenstein, J.M.7
Kotler, D.P.8
Fauci, A.S.9
-
10
-
-
0345298365
-
In vitro antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of HIV-1 protease
-
abstr. 184
-
Patick, A., M. Hongmei, M. Markowitz, D. Ho, and S. Webber. 1995. In vitro antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of HIV-1 protease, abstr. 184, p 88. In Proceedings of the 2nd National Conference on Human Retroviruses and Related Infections.
-
(1995)
Proceedings of the 2nd National Conference on Human Retroviruses and Related Infections
, pp. 88
-
-
Patick, A.1
Hongmei, M.2
Markowitz, M.3
Ho, D.4
Webber, S.5
-
11
-
-
0003210385
-
Phase I safety, tolerance, pharmacokinetics and food effect studies of AG1343 - A novel HIV protease inhibitor
-
abstr. LB3
-
Quart, B. D., S. K. Chapman, J. Peterkin, S. Webber, and S. Oliver. 1995. Phase I safety, tolerance, pharmacokinetics and food effect studies of AG1343 - a novel HIV protease inhibitor, abstr. LB3, p. 167. In Proceedings of the 2nd National Conference on Human Retroviruses and Related Infections.
-
(1995)
Proceedings of the 2nd National Conference on Human Retroviruses and Related Infections
, pp. 167
-
-
Quart, B.D.1
Chapman, S.K.2
Peterkin, J.3
Webber, S.4
Oliver, S.5
-
12
-
-
0027413508
-
HIV protease inhibitors: Their anti-HIV activity and potential role in treatment
-
Robbins, T., and J. Plattner. 1993. HIV protease inhibitors: their anti-HIV activity and potential role in treatment. J. Acquired Immune Defic. Syndr. 6: 162-170
-
(1993)
J. Acquired Immune Defic. Syndr.
, vol.6
, pp. 162-170
-
-
Robbins, T.1
Plattner, J.2
-
14
-
-
0028811974
-
Viral dynamics in human immunodeficiency virus type 1 infection
-
Wei, X., S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, B. H. Hahn, M. S. Saag, and G. Shaw. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature (London) 373:117-122
-
(1995)
Nature (London)
, vol.373
, pp. 117-122
-
-
Wei, X.1
Ghosh, S.K.2
Taylor, M.E.3
Johnson, V.A.4
Emini, E.A.5
Deutsch, P.6
Lifson, J.D.7
Bonhoeffer, S.8
Nowak, M.A.9
Hahn, B.H.10
Saag, M.S.11
Shaw, G.12
|