Cell type-specific regulation of the TGF-β-responsive α2(I) collagen gene by CpG methylation

Journal of Cellular Physiology

Volumn 202, Issue 3, 2005, Pages 822-830

  Yamane, Kenichi ^a,b   Suzuki, Hiroyuki ^a   Ihn, Hironobu ^b   Kato, Mitsuyasu ^a,c   Yoshikawa, Hirohide ^a   Tamaki, Kunihiko ^b  

^a CANCER INSTITUTE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; COLLAGEN TYPE 1; COLLAGEN TYPE 2; HISTONE; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ACETYLATION; ARTICLE; BINDING AFFINITY; CELL SPECIFICITY; CELL TYPE; CHROMATIN STRUCTURE; DEMETHYLATION; DNA METHYLATION; FIBROBLAST; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REPORTER GENE;

ANIMALS; AZACITIDINE; BASE SEQUENCE; CELL LINE; COLLAGEN TYPE I; CPG ISLANDS; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, REPORTER; HISTONES; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); SEQUENCE ALIGNMENT; SMAD PROTEINS; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 12944327831     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20205     Document Type: Article

References (39)

1. Antequera F, Bird A. 1993. Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci USA 90:11995-11999.
2. Boast S, Su M-W, Ramirez F, Sanchez M, Avvedimento EV. 1990. Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes. J Biol Chem 265:13351-13356.
3. Bornstein P, Sage H. 1980. Structurally distinct collagen types. Annu Rev Biochem 49:957-1003.
4. Chandler LA, DeClerck YA, Bogenmann E, Jones PA. 1986. Patterns of DNA methylation and gene expression in human tumor cell lines. Cancer Res 46:2944-2949.
5. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. 1993. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 122:103-111.
6. Dooley S, Delvoux B, Lahme B, Mangasser-Stephan K, Gressner AM. 2000. Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatology 31:1094-1106.
7. Dooley S, Delvoux B, Streckert M, Bonzel L, Stopa M, ten Dijke P, Gressner AM. 2001. Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells. FEBS Lett 502:4-10.
8. Gardiner-Garden M, Frommer M. 1987. CpG islands in vertebrate genomes. J Mol Biol 196:261-282.
9. Ihn H, Ohnishi K, Tamaki K, LeRoy E.C, Trojanowska M. 1996. Transcriptional regulation of the human alpha2(I) collagen gene. Combined action of upstream stimulatory and inhibitory cis-acting elements. J Biol Chem 271:26717-26723.
10. Inagaki Y, Truter S, Ramirez F. 1994. Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Spl-binding site. J Biol Chem 269:14828-14834.
11. Ioshikhes IP, Zhang MQ. 2000. Large-scale human promoter mapping using CpG islands. Nat Genet 26:61-63.
12. Jones PL, Veenstra GJ, Wade PA, Vermaak D, Kass SU, Landsberger N, Strouboulis J, Wolffe AP. 1998. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19:187-191.
13. Khillan JS, Schmidt A, Overbeek PA, de Crombrugghe B, Westphal H. 1986. Developmental and tissue-specific expression directed by the alpha 2 type I collagen promoter in transgenic mice. Proc Natl Acad Sci USA 83:725-729.
14. Kobayashi H, Tan EM, Fleming E. 2004. Acetylation of histones associated with the p21WAF1/CIP1 gene by butyrate is not sufficient for p21WAF1/CIP1 gene transcription in human colorectal adenocarcinoma cells. Int J Cancer 109:207-213.
15. Lafsen F, Gundersen G, Lopez R, Prydz H. 1992. CpG islands as gene markers in the human genome. Genomics 13:1095-1107.
16. Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney JM, Kim EG, Choi JY, Ryoo HM, Bae SC. 2000. Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20:8783-8792.
17. McKeon C, Ohkubo H, Pastan I, de Crombrugghe B. 1982. Unusual methylation pattern of the alpha 2 (I) collagen gene. Cell 29:203-210.
18. McKeon C, Pastan I, de Crombrugghe B. 1984. DNase I sensitivity of the alpha 2(1) collagen gene: Correlation with its expression but not with its methylation pattern. Nucleic Acids Res 12:3491-3502.
19. Miyazono K, ten Dijke P, Heldin CH. 2000. TGF-beta signaling by Smad proteins. Adv Immunol 75:115-157.
20. Nishihara A, Watabe T, Imamura T, Miyazono K. 2002. Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol Biol Cell 13:3055-3063.
21. Ota T, Fujii M, Sugizaki T, Ishii M, Miyazawa K, Aburatani H, Miyazono K. 2002. Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells. J Cell Physiol 193:299-318.
22. Parker MI, Judge K, Gevers W. 1982. Loss of type I procollagen gene expression in SV40-transformed human fibroblasts is accompanied by hypermethylation of these genes. Nucleic Acids Res 10:5879-5891.
23. Pierce GF, Vande Berg J, Rudolph R, Tarpley J, Mustoe TA. 1991. Platelet-derived growth factor-BB and transforming growth factor beta 1 selectively modulate glycosaminoglycans, collagen, and myofibroblasts in excisional wounds. Am J Pathol 138:629-646.
24. Ramirez F, Di Liberto M. 1990. Complex and diversified regulatory programs control the expression of vertebrate collagen genes. FASEB J 4:1616-1623.
25. Razin A, Riggs AD. 1980. DNA methylation and gene function. Science 210:604-610.
26. Rhodes K, Breindl M. 1992. Developmental changes in the methylation status of regulatory elements in the murine alpha 1(1) collagen gene. Gene Expr 2:59-69.
27. Roberts AB, Sporn MB. 1990. Transforming growth factor-beta. New York: Springer-Verlag. pp 419-472.
28. Shiota K, Kogo Y, Ohgane J, Imamura T, Urano A, Nishino K, Tanaka S, Hattori N. 2002. Epigenetic marks by DNA methylation specific to stem, germ, and somatic cells in mice. Genes Cells 7(9):961-969.
29. Smith BD, Marsilio E. 1988. Methylation of the alpha 2(1) collagen gene in chemically transformed rat liver epithelial cells. Biochem J 253:269-273.
30. Sokolov BP, Mays PK, Khillan JS, Prockop DJ. 1993. Tissue- and development-specific expression in transgenic mice of a type I procollagen (COL1A1) minigene construct with 2.3 kb of the promoter region and 2 kb of the 3′-flanking region. Specificity is independent of the putative regulatory sequences in the first intron. Biochemistry 32:9242-9249.
31. Takatsu M, Uyeno S, Komura J, Watanabe M, Ono T. 1999. Age-dependent alterations in mRNA level and promoter methylation of collagen alpha1(I) gene in human periodontal ligament. Mech Ageing Dev 110:37-48.
32. Tamai K, Silos SA, Li K, Korkeela E, Ishikawa H, Uitto J. 1995. Tissue-specific expression of the 230-kDa bullous pemphigoid antigen gene (BPAG1). Identification of a novel keratinocyte regulatory cis-element KRE3. J Biol Chem 270:7609-7614.
33. Tamaki T, Ohnishi K, Hartl C, LeRoy EC, Trojanowska M. 1995. Characterization of a GC-rich region containing Sp1 binding site(s) as a constitutive responsive element of the alpha 2(1) collagen gene in human fibroblasts. J Biol Chem 270:4299-4304.
34. Thompson JP, Simkevich CP, Holness MA, Kang AH, Raghow R. 1991. In vitro methylation of the promoter and enhancer of Pro alpha 1(1) collagen gene leads to its transcriptional inactivation. J Biol Chem 266:2549-2556.
35. Tsuji K, Ito Y, Noda M. 1998. Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells. Bone 22:87-92.
36. Vuorio E, de Crombrugghe B. 1990. The family of collagen genes. Annu Rev Biochem 59:837-872.
37. Yoshikawa H, Matsubara K, Qian GS, Jackson P, Groopman JD, Manning JE, Harris CC, Herman JG. 2001. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 28:29-35.
38. Zhang M, Maass N, Magit D, Sager R. 1997. Transactivation through Ets and Ap1 transcription sites determines the expression of the tumor-suppressing gene maspin. Cell Growth Differ 8:179-186.
39. Zhang W, Ou J, Inagaki Y, Greenwel P, Ramirez F. 2000. Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription. J Biol Chem 275:39237-39245.