Phototoxicity in human lens epithelial cells promoted by St. John's Wort

Photochemistry and Photobiology

Volumn 80, Issue 3, 2004, Pages 583-586

  He, Yu Ying ^a   Chignell, Colin F ^a   Miller, David S ^a   Andley, Usha P ^b   Roberts, Joan E ^c  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c FORDHAM UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIDEPRESSANT AGENT; ANTIOXIDANT; HYPERICIN; HYPERICUM PERFORATUM EXTRACT; XANTHOPHYLL;

APOPTOSIS; ARTICLE; CATARACTOGENESIS; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; EPITHELIUM CELL; EYE TOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERICUM PERFORATUM; LENS EPITHELIUM; LIGHT ABSORPTION; LIGHT EXPOSURE; PHOTOTOXICITY; ULTRAVIOLET A RADIATION;

CELL DEATH; CELL LINE; EPITHELIAL CELLS; HUMANS; HYPERICUM; LENS, CRYSTALLINE; PERYLENE; PHOTOSENSITIZING AGENTS;

HYPERICUM PERFORATUM;

EID: 12944327386     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/2004-06-25-RA-217.1     Document Type: Article

References (32)

1. Roberts, J. E. (2001) Ocular phototoxicity. J. Photochem. Photoblol. B: Biol. 64, 136-143.
2. Roberts, J. E. (2000) Light and immunomodulation. Ann. N.Y. Acad. Sci. 917, 435-445.
3. Balasubramanian, D. (2000) Ultraviolet radiation and cataract. J. Ocul. Pharmacol. Ther. 16, 285-297.
4. Dillon, J. (1991) The photophysics and photobiology of the eye. J. Photochem. Photobiol. B: Biol. 10, 23-40.
5. Andley, U. P. (1987) Photodamage to the eye. Photochem. Photobiol. 46, 1057-1066.
6. Barker, F. M., G. C. Brainard and P. Dayhaw-Barker (1991) Transmission of the human lens as a function of age. Investig. Ophthalmol. Vis. Sci. 32S, 1083.
7. Roberts, J. E. (2002) Screening for ocular phototoxicity. Int. J. Toxicol. 21, 491-500.
8. Vitiello, B. (1999) Hypericum perforatum extracts as potential antidepressants. J. Pharm. Pharmacol. 51, 513-517.
9. Whiskey, E., U. Werneke and D. Taylor (2001) A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review. Int. Clin. Psychopharmacol. 16, 239-252.
10. Cosmetic Ingredient Review (2001) Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil. Int. J. Toxicol. 20(Suppl. 2), 31-39.
11. Ehrenberg, B., J. L. Anderson and C. S. Foote (1998) Kinetics and yield of singlet oxygen photosensitized by hypericin in organic and biological media. Photochem. Photobiol. 68, 135-140.
12. Gulick, R. M., V. McAuliffe, J. Holden-Wiltse, C. Crumpacker, L. Liebes, D. S. Stein, P. Meehan, S. Hussey, J. Forcht and F. T. Valentine (1999) Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults-AIDS clinical trials group protocols 150 and 258. Ann. Intern. Med. 130, 510-514.
13. Cotterill, J. A. (2001) Severe phototoxic reaction to laser treatment in a patient taking St John's Wort. J. Cosmet. Laser Ther. 3, 159-160.
14. Lenard, J., A. Rabson and R. Vanderoef (1993) Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. Proc. Natl. Acad. Sci. USA 90, 158-162.
15. Higuchi, A., H. Yamada, E. Yamada and M. Matsumura (2003) Inhibitory effect of hypericin on retinal and choroidal neovascularization. Investig. Ophthalmol. Vis. Sci. 44, 554.
16. Schempp, C. M., B. Winghofer, M. Langheinrich, E. Schopf and J. C. Simon (1999) Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John's wort). Skin Pharmacol. Appl. Skin Physiol. 12, 299-304.
17. Harris, M. S., T. Sakamoto, H. Kimura, S. He, C. Spee, R. Gopalakrishna, U. Gundimeda, J. S. Yoo, D. R. Hinton and S. J. Ryan (1996) Hypericin inhibits cell growth and induces apoptosis in retinal pigment epithelial cells: possible involvement of protein kinase C. Curr. Eye Res. 15, 255-262.
18. Sgarbossa, A., N. Angelini, D. Gioffre, T. Youssef, F. Lenci and J. E. Roberts (2000) The uptake, location and fluorescence of hypericin in bovine intact lens. Curr. Eye Res. 21, 597-601.
19. Schey, K. L., S. Patat, C. F. Chignell, M. Datillo, R. H. Wang and J. E. Roberts (2000) Photooxidation of lens alpha-crystallin by hypericin (active ingredient in St. John's Wort). Photochem. Photobiol. 72, 200-203.
20. Wahlman, J., M. Hirst, J. E. Roberts, C. D. Prickelt and J. R. Trevithick (2003) Focal length variability and protein leakage as tools for measuring photooxidative damage to the lens. Photochem. Photobiol. 78, 88-92.
21. Busch, E. M., T. G. Gorgels, J. E. Roberts and D. van Norren (1999) The effects of two stereoisomers of N-acetylcysteine on photochemical damage by UVA and blue light in rat retina. Photochem. Photobiol. 70, 353-358.
22. Roberts, J. E., B. M. Kukielczak, D. N. Hu, D. S. Miller, P. Bilski, R. H. Sik, A. G. Motten and C. F. Chignell (2002) The role of A2E in prevention or enhancement of light damage in human retinal pigment epithelial cells. Photochem. Photobiol. 75, 184-190.
23. Andley, U. P., J. S. Rhim, L. T. Chylack Jr. and T. P. Fleming (1994) Propagation and immortalization of human lens epithelial cells in culture. Investig. Ophthalmol. Vis. Sci. 35, 3094-3102.
24. Martin, S. J., C. P. Reutelingsperger, A. J. McGahon, J. A. Rader, R. C. van Schie, D. M. LaFace and D. R. Green (1995) Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182, 1545-1556.
25. Reno, F., S. Burattini, S. Rossi, F. Luchetti, M. Columbaro, S. Santi, S. Papa and E. Falcieri (1998) Phospholipid rearrangement of apoptotic membrane does not depend on nuclear activity. Histochem. Cell Biol. 110, 467-476.
26. Roberts, J. E., C. E. Reme, J. Dillon and M. Terman (1992) Exposure to bright light and the concurrent use of photosensitizing drugs. N. Engl. J. Med. 326, 1500-1501.
27. Sliney, D. H. (1987) Estimating the solar ultraviolet radiation exposure to an intraocular lens implant. J. Cataract Refract. Surg. 13, 296-301.
28. Sliney, D. H. (1986) Physical factors in cataractogenesis: ambient ultraviolet radiation and temperature. Investig. Ophthalmol. Vis. Sci. 27, 781-790.
29. Diffey, B. L. (1977) The calculation of the spectral distribution of natural ultraviolet radiation under clear day conditions. Phys. Med. Biol. 22, 309-316.
30. Hammond Jr., B. R., B. R. Woolen and D. M. Snodderly (1997) Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. Optom. Vis. Sci. 74, 499-504.
31. Yeum, K. J., A. Taylor, G. Tang and R. M. Russell (1995) Measurement of carotenoids, retinoids, and tocopherols in human lenses. Investig. Ophthalmol. Vis. Sci. 36, 2756-2761.
32. Hankinson, S. E., M. J. Stampfer, J. M. Seddon, G. A. Colditz, B. Rosner, F. E. Speizer and W. C. Willett (1992) Nutrient intake and cataract extraction in women: a prospective study. Br. Med. J. 305, 335-339.